Publications

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Papers Published in 2023

  • PET Imaging of Hepatocellular Carcinoma Using ZD2-(68Ga-NOTA). Olga Sergeeva, Yifan Zhang, Songqi Gao, E Ricky Chan, Maxim Sergeev, Renuka Iyer, Sandra Sexton, Norbert Avril, Zheng-Rong Lu, Zhenghong Lee. Journal of Hepatocellular Carcinoma. [Abstract]
  • Evaluating Dual-Targeted ECO/siRNA Nanoparticles against an Oncogenic lncRNA for Triple Negative Breast Cancer Therapy with Magnetic Resonance Molecular Imaging. Calin Nicolescu, Andrew Schilb, Jiyoon Kim, Da Sun, Ryan Hall, Songqi Gao, Hannah Gilmore, William P Schiemann, Zheng-Rong Lu. Chemical & Biomedical Imaging. [Abstract]
  • RNA-Seq Analysis of Extradomain A and Extradomain B Fibronectin as Extracellular Matrix Markers for Cancer. Ryan Hall, Amita Vaidya, William Schiemann, Quentin Pan, and Zheng-Rong Lu. Cells. [Abstract]
  • Structure and Function of Cationic and Ionizable Lipids for Nucleic Acid Delivery. Da Sun & Zheng-Rong Lu. Pharmaceutical Research. [Abstract]

Papers Published in 2022

  • Targeted Contrast Agents for Magnetic Resonance Molecular Imaging of Cancer. Zheng-Rong Lu, Victoria Laney, Yajuan Li. Accounts of Chemical Research. [Abstract]
  • Effective Gene Therapy of Stargardt Disease with PEG-ECO/pGRK1-ABCA4-S/MAR Nanoparticles. Da Sun, Wenyu Sun, Song-Qi Gao, Jonathan Lehrer, Amirreza Naderi, Cheng Wei, Sangjoon Lee, Andrew L Schilb, Josef Scheidt, Ryan C Hall, Elias I Traboulsi, Krzysztof Palczewski, Zheng-Rong Lu. Molecular Therapy-Nucleic Acids. [Abstract]
  • Evaluation of Physicochemical Properties, Pharmacokinetics, Biodistribution, Toxicity, and Contrast-Enhanced Cancer MRI of a Cancer-Targeting Contrast Agent, MT218. Yajuan Li, Songqi Gao, Hongfa Jiang, Nadia Ayat, Victoria Laney, Calin Nicolescu, Wenyu Sun, Michael F Tweedle, Zheng-Rong Lu. Investigative Radiology. [Abstract]
  • Regulating Oncogenic LncRNA DANCR with Targeted ECO/siRNA Nanoparticles for Non-Small Cell Lung Cancer Therapy. Calin Nicolescu, Amita Vaidya, Andrew Schilb, and Zheng-Rong Lu. ACS Omega [Abstract]
  • Manganese(II) EOB-Pyclen Diacetate for Liver-Specific MRI. Ryan C Hall, Jingcan Qin, Victoria Laney, Nadia Ayat, Zheng-Rong Lu. ACS Applied Bio Materials [Abstract]

Papers Published in 2021

  • Magnetic resonance molecular imaging of extradomain B fibronectin enables detection of pancreatic ductal adenocarcinoma metastasis. Peter L Qiao, Mahdusudhana Gargesha, Yiqiao Liu, Victoria EA Laney, Ryan C Hall, Amita M Vaidya, Hannah Gilmore, Kara Gawelek, Bryan B Scott, Debashish Roy, David L Wilson, Zheng-Rong Lu. Magnetic Resonance Imaging [Abstract]
  • Optimization of Synthesis of the Amino Lipid ECO for Effective Delivery of Nucleic Acids. Andrew L Schilb, Josef H Scheidt, Amita M Vaidya, Zhanhu Sun, Da Sun, Sangjoon Lee, Zheng-Rong Lu. Pharmaceuticals [Abstract]
  • Quantitative analysis of metastatic breast cancer in mice using deep learning on cryo-image data. Yiqiao Liu, Madhusudhana Gargesha, Mohammed Qutaish, Zhuxian Zhou, Peter Qiao, Zheng-Rong Lu & David L. Wilson. Scientific Reports [Abstract]
  • Efficacy of Targeted ECO/miR-200c Nanoparticles for Modulating Tumor Microenvironment and Treating Triple Negative Breast Cancer as Non-invasively Monitored by MR Molecular Imaging. Andrew L Schilb, Nadia R Ayat, Amita M Vaidya, Laura M Hertz, Ryan C Hall, Josef H Scheidt, Da Sun, Zhanhu Sun, Ramamurthy Gopalakrishnan, Zheng-Rong Lu. Pharmaceutical Research. [Abstract]
  • Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. Guanping Yu, Song-Qi Gao, Zhiqian Dong, Li Sheng, Da Sun, Ning Zhang, Jianye Zhang, Seunghee Margeivicus, Pingfu Fu, Marcin Golczak, Akiko Maeda, Krzysztof Palczewski, Zheng-Rong Lu. Bioconjugate Chemistry. [Abstract] 
  • Stimuli‐Responsive Nanotheranostics. Yanglong Hou, Wenbo Bu, Hua Ai, Zheng‐Rong Lu, Twan Lammers. Advanced Healthcare Materials. [Abstract]
  • Environment‐Responsive Lipid/siRNA Nanoparticles for Cancer Therapy. Zheng‐Rong Lu, Victoria EA Laney, Ryan Hall, Nadia Ayat. Advanced Healthcare Materials. [Abstract]

Papers Published in 2020

  • Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model. Da Sun, Wenyu Sun, Song-Qi Gao, Wei Cheng, Amirreza Naderi, Andrew L Schilb, Josef Scheidt, Sangjoon Lee, Timothy Kern, Krzysztof Palczewski, Zheng-Rong Lu. Journal of Controlled Release [Abstract]
  • Preclinical Assessment of the Effectiveness of Magnetic Resonance Molecular Imaging of Extradomain-B Fibronectin for Detection and Characterization of Oral Cancer. Ryan C Hall, Nadia R Ayat, Peter L Qiao, Amita M Vaidya, Dan Ma, Anita Aminoshariae, Ivan Stojanov, Zheng-Rong Lu. Molecular Imaging and Biology. [Abstract]
  • Improving Radiation Response in Glioblastoma Using ECO/siRNA Nanoparticles Targeting DNA Damage Repair. Jennifer A Lee, Nadia Ayat, Zhanhu Sun, Philip J Tofilon, Zheng-Rong Lu, Kevin Camphausen. Cancers. [Abstract]
  • Noninvasive assessment and therapeutic monitoring of drug-resistant colorectal cancer by MR molecular imaging of extradomain-B fibronectin. Amita Vaidya, Nadia Ayat, Megan Buford, Helen Wang, Aman Shankardass, Yiqing Zhao, Hannah Gilmore, Zhenghe Wang, Zheng-Rong Lu. Theranostics. [Abstract]
  • Preclinical Assessment of the Effectiveness of Magnetic Resonance Molecular Imaging of Extradomain-B Fibronectin for Detection and Characterization of Oral Cancer. Ryan C. Hall, Nadia R. Ayat, Peter L. Qiao, Amita M. Vaidya, Dan Ma, Anita Aminoshariae, Ivan Stojanov, Zheng-Rong Lu. Molecular Imaging and Biology. [Abstract]
  • Overexpression of Extradomain-B Fibronectin is Associated with Invasion of Breast Cancer Cells. Amita Vaidya, Helen Wang, Victoria Qian, Hannah Gilmore, Zheng-Rong Lu. Cells. [Abstract]
  • Self-Assembly ECO-Plasmid DNA Nanoparticles Facilitate Robust Gene Expression Comparable to AAV2 Vector. Da Sun, Songqi Gao, Amirreza Naderi, Cheng Wei, Jonathan Lehrer, Xujie Liu, Zheng-Rong Lu. Investigative Ophthalmology & Visual Science. [Abstract]
  • Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium. Da Sun, Rebecca M Schur, Avery E Sears, Song-Qi Gao, Wenyu Sun, Amirreza Naderi, Timothy Kern, Krzysztof Palczewski, Zheng-Rong Lu. ACS Applied Bio Materials. [Abstract]
  • Role of eIF4E on epithelial‐mesenchymal transition, invasion, and chemoresistance of prostate cancer cells. Xujie Liu, Amita M Vaidya, Da Sun, Yan Zhang, Nadia Ayat, Andrew Schilb, Zheng‐Rong Lu. Cancer Communications. [Abstract]
  • Deep learning based multi-organ segmentation and metastases segmentation in whole mouse body and the cryo-imaging cancer imaging and therapy analysis platform (CITAP). Yiqiao Liu, Madhu Gargesha, Mohammed Qutaish, Zhuxian Zhou, Bryan Scott, Hamed Yousefi, Zhengrong Lu, David L. Wilson. Proc. SPIE 11317, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging. [Abstract]
  • Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. Sun D, Schur RM, Sears AE, Gao SQ, Vaidya A, Sun W, Maeda A, Kern T, Palczewski K, Lu ZR. Molecular Therapy. [Abstract]
  • Fibronectin in the Tumor Microenvironment. Peter Qiao, Zheng-Rong Lu. Tumor Microenvironment. [Abstract]

Papers Published in 2019

  • Synthesis and assessment of ZD2-(68Ga-NOTA) specific to extradomain B fibronectin in tumor microenvironment for PET imaging of pancreatic cancer. G Songqi, Q Jing-Can, O Sergeeva, M Sergeev, P Qiao, S Roelle, N Avril, Z Lee, Y Li, Z-R Lu. American Journal of Nuclear Medicine and Molecular Imaging. [Abstract]
  • Effective MR Molecular Imaging of Triple Negative Breast Cancer With an EDB-Fibronectin-Specific Contrast Agent at Reduced Doses. Ayat NR, Vaidya A, Yeung GA, Buford MN, Hall RC, Qiao PL, Yu X, Lu ZR. Frontiers in Oncology. [Abstract].
  • Formulation of Biocompatible Targeted ECO/siRNA Nanoparticles with Long-Term Stability for Clinical Translation of RNAi. Ayat NR, Sun Z, Sun D, Yin M, Hall RC, Vaidya AM, Liu X, Schilb AL, Scheidt JH, Lu ZR. Nucleic Acid Therapeutics. [Abstract].
  • Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy. Vaidya AM, Sun Z, Ayat NR, Schilb A, Liu X, Jiang H, Sun D, Scheidt J, Qian V, He S, Gilmore H, Scheimann W, Lu ZR. Bioconjugate Chemistry. [Abstract]
  • Preparation and Evaluation of ZD2 Peptide 64Cu-DOTA Conjugate as a Positron Emission Tomography Probe for Detection and Characterization of Prostate Cancer. Han Z, Sergeeva O, Roelle S, Gao S, Li Y, Lee Z, Lu ZR.  ACS Omega. [Abstract]

Papers Published in 2018

  • Synthesis and Evaluation of pH-Sensitive Multifunctional Lipids for Efficient Delivery of CRISPR/Cas9 in Gene Editing. Sun D, Sun Z, Jiang H, Vaidya AM, Xin R, Ayat NR, Schilb AL, Qiao PL, Han Z, Naderi A, Lu ZR. Bioconjugate chemistry. 2018 [Abstract]
  • Optimization of ZD2 Peptide Targeted Gd(HP-DO3A) for Detection and Risk-Stratification of Prostate Cancer with MRI. Ayat NR, Qin JC, Cheng H, Roelle S, Gao S, Li Y, Lu ZR. ACS Med Chem Lett. 2018 [Abstract]
  • New GABA moculators protect photoreceptor cells from light-induced degeneration in mouse models. Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. FASEB J. 2018 [Abstract]
  • Magnetic resonance molecular imaging of metastatic breast cancer by targeting extradomain-B fibronectin in the tumor microenviornment. Han Z, Cheng H, Parvani JG, Zhou Z, Lu ZR. Magn Reson Med. 2018 [Abstract]
  • Drug Delivery in Cancer Therapy, Quo Vadis? Lu ZR, Qiao P. Mol. Pharm. 2018 [Abstract]
  • Targeted gadofullerene for sensitive magnetic resonance imaging and risk-stratification of breast cancer. Han Z, Wu X, Roelle S, Chen C, Schiemann WP, Lu ZR. Nat Comm. 2018 [Abstract]

Papers Published in 2017

  • Synthesis and Assessment of Peptide Gd-DOTA Conjugates Targeting Extradomain B Fibronectin for Magnetic Resonance Molecular Imaging of Prostate Cancer. Li Y, Han Z, Roelle S, DeSanto A, Sabatelle R, Schur R, Lu ZR. Mol Pharm 2017 [Abstract]
  • A novel nonviral gene delivery system for treating Leber's congenital amaurosis. Sun D, Schur RM, Lu ZR. Ther Deliv. 2017 [Abstract]
  • Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Mol Ther Nucleic Acids 2017. [Abstract]
  • A Targeted Contrast Agent Specific to an Oncoprotein in Tumor Microenvironment with the Potential for Detection and Risk Stratification of Prostate Cancer with MRI. Han Z, Li Y, Roelle S, Zhou Z, Liu Y, Sabatelle R, DeSanto A, Yu X, Zhu H, Magi-Galluzzi C, Lu ZR. Bioconjug Chem. 2017 [Abstract]
  • Molecular imaging for precision medicine. Lu ZR, Minko T. Adv Drug Deliv Rev. 2017 [Abstract]
  • Molecular imaging of the tumor microenviornment. Zhou Z, Lu ZR. Adv Drug Deliv Rev. 2017 [Abstract]
  • Targeting Fibronectin for Cancer Imaging and Therapy. Han Z, Lu ZR. J Mater Chem B. 2017 [Abstract]

Papers Published in 2016

  • Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy. Gujrati M, Vaidya AM, Mack M, Snyder D, Malamas A, Lu ZR. Adv Healthc Mater. 2016. (22): 2882-2895. [Abstract]
  • Influence of Molecular Structure on the In Vivo Performance of Flexible Rod Polyrotaxanes. Collins CJ, Mondjinou Y, Loren B, Torregrosa-Allen S, Simmons CJ, Elzey BD, Ayat N, Lu ZR, Thompson D. 2016. 17(9):2777-86. [Abstract]
  • Molecular imaging of the tumor microenviornment. Zhou Z, Lu ZR. Adv Drug Deliv Rev. 2016. [Abstract]
  • Dynamic Contrast Enhanced MRI Assessing the Antiangiogenic Effect of Silencing HIF-1α with Targeted Multifunctional ECO/siRNA Nanoparticles. Malamas AS, Jin E, Gujrati M, Lu ZR. Mol Pharm. 2016, 13(7): 2497-506. [Abstract]
  • Targeted Mesoporous Silica Nanoparticles Delivering Arsenic Trioxide with Environment Sensitive Drug Release for Effective Treatment of Triple Negative Breast Cancer. Wu X, Han Z, Schur RM, Lu ZR. ACS Biomaterials Science & Engineering, Accepted. 
  • A targeted nanoglobular contrast agent from host-guest self assembly for MR cancer molecular imaging. Zhou Z, Han Z, and Lu ZR. Biomaterials, 2016, 85:168-79. [Abstract]
  • Multifunctional pH-Sensitive Amino Lipids for siRNA Delivery. Gujrati M, Vaidya A, and Lu ZR. Bioconjugate Chem. 2016, 27(1): 19-35 [Abstract]
  • Chitosan oligosaccharide based Gd-DTPA complex as a potential biomodal magnetic resonance imaging contrast agent. Huang Y, Cao J, Zhang Q, Lu ZR, Hua MQ, Zhang XY, Gao H. Magn Reson Imaging. 2016, 34(1):1-7. [Abstract]

Papers Published 2015

  • ECO/siRNA nanoparticles and breast cancer metastasis. Lu ZR and Schiemann WP. Oncoscience, 2015, 2(10): 823-4. [Abstract]
  • Gd3+-1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic-2-hydroxypropyl-β cyclodextrin- Pluronic Polyrotaxane as a Long Circulating High Relaxivity MRI Contrast Agent. Zhou Z, Mondjinou Y, Hyun SH, Kulkarni A, Lu ZR, Thompson DH. ACS Appl. Mater. Interfaces, 2015, 7(40):22272-6. [Abstract]
  • Self assembly of a multifunctional lipid with core-shell dendrimer DNA nanoparticles enhanced efficient gene delivery at low charge ratios in RPE cells. Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, and Lu ZR. Macromolecular Bioscience, 2015, 15(12):1663-72. (Featured) [Abstract]
  • MRI detection of Breast Cancer Micrometastases with a fibronectin targeting contrast agent. Zhou Z, Qutaish M, Han Z, Schur RM, Liu Y, Wilson DL, and Lu ZR. Nature Commun. 2015, 6:7984.  (Press Release: NIBIB) [Abstract]
  • A neutral polydisulfide containing Gd(III) DOTA monoamide as a redox-sensitive biodegradable macromolecular MRI contrast agent. Ye Z, Zhou Z, Ayat N, Wu X, Jin E, Shi X, Lu ZR. Contrast Media and Molecular Imaging, 2016, 11(1):32-40 [Abstract]
  • Molecular imaging of tumors using a quantitative T1 mapping technique via magnetic resonance imaging. Herrmann K, Johansen ML, Craig SE, Vincent J, Howell M, Gao Y, Lu L, Erokwu B, Agnes RS, Lu ZR, Pokorski JK, Basilion J, Gulani V, Griswold M, Flask C, Brady-Kalnay S. Diagnostics 2015, 5 (3), 318-332 [Abstract]
  • Manganese-enhanced MRI for preclinical evaluation of retinal degeneration treatment.Schur R, Sheng L, Sahu B, Yu G, Gao S, Yu X, Maeda A, Palczewski K, and Lu ZR. Invest. Opththal. Vis. Sci. 2015, 56(8):4936-42 [Abstract]
  • An EDB fibronectin specific peptide for prostate cancer targeting. Han Z, Zhou Z, Shi X, Wang J, Wu X, Sun D, Chen Y, Zhu H,  Magi-Galluzzi C, and Lu ZR. Bioconjugate Chem. 2015, 20;26(5):830-8 [Abstract]
  • Silencing β3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple Negative Breast Cancer. Parvani, JG. Gujrati,MD. Mack, MA. Schiemann, WP and Lu ZR. Cancer Res. 2015, accepted. 2015, 1;75(11):2316-25 [Abstract]
  • Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles.Puntel A, Maeda A, Golczak M, Gao SQ, Yu G, Palczewski K, Lu ZR. Biomaterials. 2015, 44:103-110. [Abstract]
  • Anti-angiogenic Effects of Bumetanide Revealed by DCE-MRI with a Biodegradable Macromolecular Contrast Agent in a Colon Cancer Model. Malamas AS, Jin E, Zhang Q, Haaga J, Lu ZR. Pharm Res. 2015. [Abstract]
  • RNA interference targeting hypoxia-inducible factor 1alpha via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model. Gillespie DL, Aguirre MT, Ravichandran S, Leishman LL, Berrondo C, Gamboa JT, Wang L, King R, Wang X, Tan M, Malamas A, Lu ZR, Jensen RL. J Neurosurg. 2015, 122(2):331-341. [Abstract]