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Papers Published in 2022

  • Targeted Contrast Agents for Magnetic Resonance Molecular Imaging of Cancer. Zheng-Rong Lu, Victoria Laney, Yajuan Li. Accounts of Chemical Research. [Abstract]
  • Effective Gene Therapy of Stargardt Disease with PEG-ECO/pGRK1-ABCA4-S/MAR Nanoparticles. Da Sun, Wenyu Sun, Song-Qi Gao, Jonathan Lehrer, Amirreza Naderi, Cheng Wei, Sangjoon Lee, Andrew L Schilb, Josef Scheidt, Ryan C Hall, Elias I Traboulsi, Krzysztof Palczewski, Zheng-Rong Lu. Molecular Therapy-Nucleic Acids. [Abstract]
  • Evaluation of Physicochemical Properties, Pharmacokinetics, Biodistribution, Toxicity, and Contrast-Enhanced Cancer MRI of a Cancer-Targeting Contrast Agent, MT218. Yajuan Li, Songqi Gao, Hongfa Jiang, Nadia Ayat, Victoria Laney, Calin Nicolescu, Wenyu Sun, Michael F Tweedle, Zheng-Rong Lu. Investigative Radiology. [Abstract]
  • Regulating Oncogenic LncRNA DANCR with Targeted ECO/siRNA Nanoparticles for Non-Small Cell Lung Cancer Therapy. Calin Nicolescu, Amita Vaidya, Andrew Schilb, and Zheng-Rong Lu. ACS Omega [Abstract]
  • Manganese(II) EOB-Pyclen Diacetate for Liver-Specific MRI. Ryan C Hall, Jingcan Qin, Victoria Laney, Nadia Ayat, Zheng-Rong Lu. ACS Applied Bio Materials [Abstract]

Papers Published in 2021

  • Magnetic resonance molecular imaging of extradomain B fibronectin enables detection of pancreatic ductal adenocarcinoma metastasis. Peter L Qiao, Mahdusudhana Gargesha, Yiqiao Liu, Victoria EA Laney, Ryan C Hall, Amita M Vaidya, Hannah Gilmore, Kara Gawelek, Bryan B Scott, Debashish Roy, David L Wilson, Zheng-Rong Lu. Magnetic Resonance Imaging [Abstract]
  • Optimization of Synthesis of the Amino Lipid ECO for Effective Delivery of Nucleic Acids. Andrew L Schilb, Josef H Scheidt, Amita M Vaidya, Zhanhu Sun, Da Sun, Sangjoon Lee, Zheng-Rong Lu. Pharmaceuticals [Abstract]
  • Quantitative analysis of metastatic breast cancer in mice using deep learning on cryo-image data. Yiqiao Liu, Madhusudhana Gargesha, Mohammed Qutaish, Zhuxian Zhou, Peter Qiao, Zheng-Rong Lu & David L. Wilson. Scientific Reports [Abstract]
  • Efficacy of Targeted ECO/miR-200c Nanoparticles for Modulating Tumor Microenvironment and Treating Triple Negative Breast Cancer as Non-invasively Monitored by MR Molecular Imaging. Andrew L Schilb, Nadia R Ayat, Amita M Vaidya, Laura M Hertz, Ryan C Hall, Josef H Scheidt, Da Sun, Zhanhu Sun, Ramamurthy Gopalakrishnan, Zheng-Rong Lu. Pharmaceutical Research. [Abstract]
  • Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. Guanping Yu, Song-Qi Gao, Zhiqian Dong, Li Sheng, Da Sun, Ning Zhang, Jianye Zhang, Seunghee Margeivicus, Pingfu Fu, Marcin Golczak, Akiko Maeda, Krzysztof Palczewski, Zheng-Rong Lu. Bioconjugate Chemistry. [Abstract
  • Stimuli‐Responsive Nanotheranostics. Yanglong Hou, Wenbo Bu, Hua Ai, Zheng‐Rong Lu, Twan Lammers. Advanced Healthcare Materials. [Abstract]
  • Environment‐Responsive Lipid/siRNA Nanoparticles for Cancer Therapy. Zheng‐Rong Lu, Victoria EA Laney, Ryan Hall, Nadia Ayat. Advanced Healthcare Materials. [Abstract]

Papers Published in 2020

  • Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model. Da Sun, Wenyu Sun, Song-Qi Gao, Wei Cheng, Amirreza Naderi, Andrew L Schilb, Josef Scheidt, Sangjoon Lee, Timothy Kern, Krzysztof Palczewski, Zheng-Rong Lu. Journal of Controlled Release [Abstract]
  • Preclinical Assessment of the Effectiveness of Magnetic Resonance Molecular Imaging of Extradomain-B Fibronectin for Detection and Characterization of Oral Cancer. Ryan C Hall, Nadia R Ayat, Peter L Qiao, Amita M Vaidya, Dan Ma, Anita Aminoshariae, Ivan Stojanov, Zheng-Rong Lu. Molecular Imaging and Biology. [Abstract]
  • Improving Radiation Response in Glioblastoma Using ECO/siRNA Nanoparticles Targeting DNA Damage Repair. Jennifer A Lee, Nadia Ayat, Zhanhu Sun, Philip J Tofilon, Zheng-Rong Lu, Kevin Camphausen. Cancers. [Abstract]
  • Noninvasive assessment and therapeutic monitoring of drug-resistant colorectal cancer by MR molecular imaging of extradomain-B fibronectin. Amita Vaidya, Nadia Ayat, Megan Buford, Helen Wang, Aman Shankardass, Yiqing Zhao, Hannah Gilmore, Zhenghe Wang, Zheng-Rong Lu. Theranostics. [Abstract]
  • Preclinical Assessment of the Effectiveness of Magnetic Resonance Molecular Imaging of Extradomain-B Fibronectin for Detection and Characterization of Oral Cancer. Ryan C. Hall, Nadia R. Ayat, Peter L. Qiao, Amita M. Vaidya, Dan Ma, Anita Aminoshariae, Ivan Stojanov, Zheng-Rong Lu. Molecular Imaging and Biology. [Abstract]
  • Overexpression of Extradomain-B Fibronectin is Associated with Invasion of Breast Cancer Cells. Amita Vaidya, Helen Wang, Victoria Qian, Hannah Gilmore, Zheng-Rong Lu. Cells. [Abstract]
  • Self-Assembly ECO-Plasmid DNA Nanoparticles Facilitate Robust Gene Expression Comparable to AAV2 Vector. Da Sun, Songqi Gao, Amirreza Naderi, Cheng Wei, Jonathan Lehrer, Xujie Liu, Zheng-Rong Lu. Investigative Ophthalmology & Visual Science. [Abstract]
  • Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium. Da Sun, Rebecca M Schur, Avery E Sears, Song-Qi Gao, Wenyu Sun, Amirreza Naderi, Timothy Kern, Krzysztof Palczewski, Zheng-Rong Lu. ACS Applied Bio Materials. [Abstract]
  • Role of eIF4E on epithelial‐mesenchymal transition, invasion, and chemoresistance of prostate cancer cells. Xujie Liu, Amita M Vaidya, Da Sun, Yan Zhang, Nadia Ayat, Andrew Schilb, Zheng‐Rong Lu. Cancer Communications. [Abstract]
  • Deep learning based multi-organ segmentation and metastases segmentation in whole mouse body and the cryo-imaging cancer imaging and therapy analysis platform (CITAP). Yiqiao Liu, Madhu Gargesha, Mohammed Qutaish, Zhuxian Zhou, Bryan Scott, Hamed Yousefi, Zhengrong Lu, David L. Wilson. Proc. SPIE 11317, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging. [Abstract]
  • Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. Sun D, Schur RM, Sears AE, Gao SQ, Vaidya A, Sun W, Maeda A, Kern T, Palczewski K, Lu ZR. Molecular Therapy. [Abstract]
  • Fibronectin in the Tumor Microenvironment. Peter Qiao, Zheng-Rong Lu. Tumor Microenvironment. [Abstract]

Papers Published in 2019

  • Synthesis and assessment of ZD2-(68Ga-NOTA) specific to extradomain B fibronectin in tumor microenvironment for PET imaging of pancreatic cancer. G Songqi, Q Jing-Can, O Sergeeva, M Sergeev, P Qiao, S Roelle, N Avril, Z Lee, Y Li, Z-R Lu. American Journal of Nuclear Medicine and Molecular Imaging. [Abstract]
  • Effective MR Molecular Imaging of Triple Negative Breast Cancer With an EDB-Fibronectin-Specific Contrast Agent at Reduced Doses. Ayat NR, Vaidya A, Yeung GA, Buford MN, Hall RC, Qiao PL, Yu X, Lu ZR. Frontiers in Oncology. [Abstract].
  • Formulation of Biocompatible Targeted ECO/siRNA Nanoparticles with Long-Term Stability for Clinical Translation of RNAi. Ayat NR, Sun Z, Sun D, Yin M, Hall RC, Vaidya AM, Liu X, Schilb AL, Scheidt JH, Lu ZR. Nucleic Acid Therapeutics. [Abstract].
  • Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy. Vaidya AM, Sun Z, Ayat NR, Schilb A, Liu X, Jiang H, Sun D, Scheidt J, Qian V, He S, Gilmore H, Scheimann W, Lu ZR. Bioconjugate Chemistry. [Abstract]
  • Preparation and Evaluation of ZD2 Peptide 64Cu-DOTA Conjugate as a Positron Emission Tomography Probe for Detection and Characterization of Prostate Cancer. Han Z, Sergeeva O, Roelle S, Gao S, Li Y, Lee Z, Lu ZR.  ACS Omega. [Abstract]

Papers Published in 2018

  • Synthesis and Evaluation of pH-Sensitive Multifunctional Lipids for Efficient Delivery of CRISPR/Cas9 in Gene Editing. Sun D, Sun Z, Jiang H, Vaidya AM, Xin R, Ayat NR, Schilb AL, Qiao PL, Han Z, Naderi A, Lu ZR. Bioconjugate chemistry. 2018 [Abstract]
  • Optimization of ZD2 Peptide Targeted Gd(HP-DO3A) for Detection and Risk-Stratification of Prostate Cancer with MRI. Ayat NR, Qin JC, Cheng H, Roelle S, Gao S, Li Y, Lu ZR. ACS Med Chem Lett. 2018 [Abstract]
  • New GABA moculators protect photoreceptor cells from light-induced degeneration in mouse models. Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. FASEB J. 2018 [Abstract]
  • Magnetic resonance molecular imaging of metastatic breast cancer by targeting extradomain-B fibronectin in the tumor microenviornment. Han Z, Cheng H, Parvani JG, Zhou Z, Lu ZR. Magn Reson Med. 2018 [Abstract]
  • Drug Delivery in Cancer Therapy, Quo Vadis? Lu ZR, Qiao P. Mol. Pharm. 2018 [Abstract]
  • Targeted gadofullerene for sensitive magnetic resonance imaging and risk-stratification of breast cancer. Han Z, Wu X, Roelle S, Chen C, Schiemann WP, Lu ZR. Nat Comm. 2018 [Abstract]

Papers Published in 2017

    • Synthesis and Assessment of Peptide Gd-DOTA Conjugates Targeting Extradomain B Fibronectin for Magnetic Resonance Molecular Imaging of Prostate Cancer. Li Y, Han Z, Roelle S, DeSanto A, Sabatelle R, Schur R, Lu ZR. Mol Pharm 2017 [Abstract]
    • A novel nonviral gene delivery system for treating Leber's congenital amaurosis. Sun D, Schur RM, Lu ZR. Ther Deliv. 2017 [Abstract]
    • Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Mol Ther Nucleic Acids 2017. [Abstract]
    • A Targeted Contrast Agent Specific to an Oncoprotein in Tumor Microenvironment with the Potential for Detection and Risk Stratification of Prostate Cancer with MRI. Han Z, Li Y, Roelle S, Zhou Z, Liu Y, Sabatelle R, DeSanto A, Yu X, Zhu H, Magi-Galluzzi C, Lu ZR. Bioconjug Chem. 2017 [Abstract]
    • Molecular imaging for precision medicine. Lu ZR, Minko T. Adv Drug Deliv Rev. 2017 [Abstract]
    • Molecular imaging of the tumor microenviornment. Zhou Z, Lu ZR. Adv Drug Deliv Rev. 2017 [Abstract]
    • Targeting Fibronectin for Cancer Imaging and Therapy. Han Z, Lu ZR. J Mater Chem B. 2017 [Abstract]

    Papers Published in 2016

    • Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy. Gujrati M, Vaidya AM, Mack M, Snyder D, Malamas A, Lu ZR. Adv Healthc Mater. 2016. (22): 2882-2895. [Abstract]
    • Influence of Molecular Structure on the In Vivo Performance of Flexible Rod Polyrotaxanes. Collins CJ, Mondjinou Y, Loren B, Torregrosa-Allen S, Simmons CJ, Elzey BD, Ayat N, Lu ZR, Thompson D. 2016. 17(9):2777-86. [Abstract]
    • Molecular imaging of the tumor microenviornment. Zhou Z, Lu ZR. Adv Drug Deliv Rev. 2016. [Abstract]
    • Dynamic Contrast Enhanced MRI Assessing the Antiangiogenic Effect of Silencing HIF-1α with Targeted Multifunctional ECO/siRNA Nanoparticles. Malamas AS, Jin E, Gujrati M, Lu ZR. Mol Pharm. 2016, 13(7): 2497-506. [Abstract]
    • Targeted Mesoporous Silica Nanoparticles Delivering Arsenic Trioxide with Environment Sensitive Drug Release for Effective Treatment of Triple Negative Breast Cancer. Wu X, Han Z, Schur RM, Lu ZR. ACS Biomaterials Science & Engineering, Accepted. 
    • A targeted nanoglobular contrast agent from host-guest self assembly for MR cancer molecular imaging. Zhou Z, Han Z, and Lu ZR. Biomaterials, 2016, 85:168-79. [Abstract]
    • Multifunctional pH-Sensitive Amino Lipids for siRNA Delivery. Gujrati M, Vaidya A, and Lu ZR. Bioconjugate Chem. 2016, 27(1): 19-35 [Abstract]
    • Chitosan oligosaccharide based Gd-DTPA complex as a potential biomodal magnetic resonance imaging contrast agent. Huang Y, Cao J, Zhang Q, Lu ZR, Hua MQ, Zhang XY, Gao H. Magn Reson Imaging. 2016, 34(1):1-7. [Abstract]

    Papers Published 2015

    • ECO/siRNA nanoparticles and breast cancer metastasis. Lu ZR and Schiemann WP. Oncoscience, 2015, 2(10): 823-4. [Abstract]
    • Gd3+-1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic-2-hydroxypropyl-β cyclodextrin- Pluronic Polyrotaxane as a Long Circulating High Relaxivity MRI Contrast Agent. Zhou Z, Mondjinou Y, Hyun SH, Kulkarni A, Lu ZR, Thompson DH. ACS Appl. Mater. Interfaces, 2015, 7(40):22272-6. [Abstract]
    • Self assembly of a multifunctional lipid with core-shell dendrimer DNA nanoparticles enhanced efficient gene delivery at low charge ratios in RPE cells. Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, and Lu ZR. Macromolecular Bioscience, 2015, 15(12):1663-72. (Featured) [Abstract]
    • MRI detection of Breast Cancer Micrometastases with a fibronectin targeting contrast agent. Zhou Z, Qutaish M, Han Z, Schur RM, Liu Y, Wilson DL, and Lu ZR. Nature Commun. 2015, 6:7984.  (Press Release: NIBIB) [Abstract]
    • A neutral polydisulfide containing Gd(III) DOTA monoamide as a redox-sensitive biodegradable macromolecular MRI contrast agent. Ye Z, Zhou Z, Ayat N, Wu X, Jin E, Shi X, Lu ZR. Contrast Media and Molecular Imaging, 2016, 11(1):32-40 [Abstract]
    • Molecular imaging of tumors using a quantitative T1 mapping technique via magnetic resonance imaging. Herrmann K, Johansen ML, Craig SE, Vincent J, Howell M, Gao Y, Lu L, Erokwu B, Agnes RS, Lu ZR, Pokorski JK, Basilion J, Gulani V, Griswold M, Flask C, Brady-Kalnay S. Diagnostics 2015, 5 (3), 318-332 [Abstract]
    • Manganese-enhanced MRI for preclinical evaluation of retinal degeneration treatment.Schur R, Sheng L, Sahu B, Yu G, Gao S, Yu X, Maeda A, Palczewski K, and Lu ZR. Invest. Opththal. Vis. Sci. 2015, 56(8):4936-42 [Abstract]
    • An EDB fibronectin specific peptide for prostate cancer targeting. Han Z, Zhou Z, Shi X, Wang J, Wu X, Sun D, Chen Y, Zhu H,  Magi-Galluzzi C, and Lu ZR. Bioconjugate Chem. 2015, 20;26(5):830-8 [Abstract]
    • Silencing β3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple Negative Breast Cancer. Parvani, JG. Gujrati,MD. Mack, MA. Schiemann, WP and Lu ZR. Cancer Res2015, accepted. 2015, 1;75(11):2316-25 [Abstract]
    • Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles.Puntel A, Maeda A, Golczak M, Gao SQ, Yu G, Palczewski K, Lu ZR. Biomaterials2015, 44:103-110. [Abstract]
    • Anti-angiogenic Effects of Bumetanide Revealed by DCE-MRI with a Biodegradable Macromolecular Contrast Agent in a Colon Cancer Model. Malamas AS, Jin E, Zhang Q, Haaga J, Lu ZR. Pharm Res. 2015. [Abstract]
    • RNA interference targeting hypoxia-inducible factor 1alpha via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model. Gillespie DL, Aguirre MT, Ravichandran S, Leishman LL, Berrondo C, Gamboa JT, Wang L, King R, Wang X, Tan M, Malamas A, Lu ZR, Jensen RL. J Neurosurg2015, 122(2):331-341. [Abstract]

    Papers Published 2014

    • Dendritic nanoglobules with polyhedral oligomeric silsesquioxane core and their biomedical applications. Zhou Z, Lu ZR. Nanomedicine (Lond)2014, 9(15):2387-2401. [Abstract]
    • Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice. Yu G, Wu X, Ayat N, Maeda A, Gao SQ, Golczak M, Palczewski K, Lu ZR. Biomacromolecules2014, 15(12):4570-4578. [Abstract]
    • Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration. Wu X, Yu G, Luo C, Maeda A, Zhang N, Sun D, Zhou Z, Puntel A, Palczewski K, Lu ZR. ACS Nano2014, 8(1):153-161. [Abstract]
    • Peptide targeted high-resolution molecular imaging of prostate cancer with MRI. Wu X, Yu G, Lindner D, Brady-Kalnay SM, Zhang Q, Lu ZR. Am J Nucl Med Mol Imaging2014, 4(6):525-536. [Abstract]
    • Synthesis and evaluation of a targeted nanoglobular dual-modal imaging agent for MR imaging and image-guided surgery of prostate cancer. Tan M, Ye Z, Lindner D, Brady-Kalnay SM, Lu ZR. Pharm Res2014, 31(6):1469-1476. [Abstract]
    • Theranostics: fusion of therapeutics and diagnostics. Lu ZR. Pharm Res2014, 31(6):1355-1357. [Abstract]
    • Biodegradable iodinated polydisulfides as contrast agents for CT angiography. Jin E, Lu ZR. Biomaterials2014, 35(22):5822-5829. [Abstract]
    • Multifunctional cationic lipid-based nanoparticles facilitate endosomal escape and reduction-triggered cytosolic siRNA release. Gujrati M, Malamas A, Shin T, Jin E, Sun Y, Lu ZR. Mol Pharm2014, 11(8):2734-2744. [Abstract]
    • The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation response in GBM. Brett-Morris A, Wright BM, Seo Y, Pasupuleti V, Zhang J, Lu J, Spina R, Bar EE, Gujrati M, Schur R, Lu ZR, Welford SM. Cancer Res2014, 74(23):6925-6934. [Abstract]

    Papers Published 2013

    • Synthesis and Evaluation of a Targeted Nanoglobular Dual-Modal Imaging Agent for MR Imaging and Image-Guided Surgery of Prostate Cancer. Tan, M.-Q., Ye, Z., Lindner, D., Brady-Kalnay, S. M., Lu, Z.-R., Pharm. Res2013, [Epub ahead of print]. [Abstract]
    • Design and Evaluation of New pH-Sensitive Amphiphilic Cationic Lipids for siRNA Delivery. Malamas, A. S., Gujrati, M., Kummitha, C.M., Xu, R.-Z., Lu, Z.-R., J. Control. Rel2013, 171, 296-307. [Abstract]
    • Molecular MRI of Atherosclerotic Plaque Progression in an ApoE-/- Mouse Model with a CLT1 Peptide Targeted Macrocyclic Gd(III) Chelate. Xueming Wu, Niranjan Balu, Wen Li, Yong Chen, Xiaoyue Shi, China Kummitha, Xin Yu, Chun Yuan, and Lu, Z.-R., Am. J. Nucl. Med. Mol. Imaging2013, 3(5): 446-455. [Abstract]
    • CLT1 Peptide Targeted Small Molecular Contrast Agent for MR Molecular Imaging of Prostate Cancer. Wu, X.-M., Lindner, D., Yu, G.-P, Lu, Z.-R., J. Vis. Exp. 2013,79, e50565. [Abstract]
    • Peptide Targeted Tripod Macrocyclic Gd(III) Chelates for Cancer Molecular MRI. Zhou, Z.-X., Wu, X.-M., Kresak, A., Griswold, M., Lu, Z.-R., Biomaterials2013, 34, 7683-7693. [Abstract]
    • Molecular Magnetic Resonance Imaging of Tumors with a PTPµ Targeted Contrast Agent. Burden-Gulley, S. M., Zhou, Z.-X., Craig, S. E.L., Lu, Z.-R., Brady-Kalnay, S. M., Molecular Transl Oncol2013, 6(3), 329-337. [Abstract]
    • Single cell molecular recognition of migrating and invading tumor cells using a targeted fluorescent probe to receptor PTPmu. Burden-Gulley, S. M., Qutaish, M. Q., Sullivant, K. E., Tan, M.-Q., Craig, S.E.L., Basilion, J. P., Lu, Z.-R., Wilson, D. L., Brady-Kalnay, S. M., International J. of Cancer2013,132(7), 1624-1632. [Abstract]
    • Gadolinium-Based Contrast Agents for MR Cancer Imaging. Zhou, Z.-X., Lu, Z.-R., Wiley Interdiscip Rev Nanomed Nanobiotechnol2013, 5, 1-18. [Abstract]
    • Molecular MRI of Liver Fibrosis by a Peptide Targeted Contrast Agent in an Experimental Mouse Model. Chow, A. M., Tan, M.-Q., Gao, D. S., Fan, S.-J., Cheung, J.-S., Qiao, Z.-W., Man, K., Lu, Z.-R., Wu. E. X., Investigative Radiology2013, 48, 46-54. [Abstract]
    • Synthesis and evaluation of a polydisulfide with Gd-DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imaging. Ye, Z., Wu, X.-M., Tan, M.-Q., Jesberger, J., Griswold, M., Lu, Z.-R., Contrast Media and Molecular Imaging2013, 8, 220-228. [Abstract]


    Papers Published 2012

    • Albumin pre-coating enhances intracellular siRNA delivery of multifunctional amphiphile/siRNA nanoparticles. China Malakondaiah Kummitha, Anthony S. Malamas, Lu, Z.-R., Intl. J. Nanomedicine2012, 7, 5205-5214. [Abstract]
    • Intracellular siRNA delivery with novel spermine based surfactants. Xu, R.-Z; Wang, X.-L; Lu, Z.-R., Chin. Sci. Bull. 2012, 57, 3979-3984. (invited paper) [Abstract]
    • Synthesis and Evaluation of a Peptide Targeted Small Molecular Gd-DOTA Monoamide Conjugate for MR Molecular Imaging of Prostate Cancer. Wu, X.; Burden-Gulley, S. M.; Yu, G.-P.; Tan, M.; Lindner, D.; Brady-Kalnay, S. M.; Lu, Z.-R., Bioconjugate Chem. 2012, 23, 1548-1556. [Abstract]
    • Polydisulfide manganese(II) complexes as non-gadolinium biodegradable macromolecular MRI contrast agents, Ye, Z.; Jeong, E. K.; Wu, X. M.; Tan, M. Q.; Yin, S. Y.; Lu, Z. R. Journal of Magnetic Resonance Imaging 2012, 35, 737-744. [Abstract]
    • MR Molecular Imaging of Prostate Cancer with a Peptide-Targeted Contrast Agent in a Mouse Orthotopic Prostate Cancer Model, Tan, M. Q.; Burden-Gulley, S. M.; Li, W.; Wu, X. M.; Lindner, D.; Brady-Kalnay, S. M.; Gulani, V.; Lu, Z. R. Pharmaceutical Research 2012, 29, 953-960. [Abstract]
    • pH-sensitive siRNA delivery systems, Lu, Z. R. Journal of Drug Delivery Science and Technology 2012, 22, 55-63. [Abstract]

    Papers Published 2011

    • Design, synthesis and evaluation of spermine-based pH-sensitive amphiphilic gene delivery systems: Multifunctional non-viral gene carriers, Xu, R.; Lu, Z. R. Science China-Chemistry 2011,54, 359-368.[Abstract] (invited)
    • Evaluation of CLT1-(Gd-DTPA) for MR molecular imaging in a mouse breast cancer model. Ye, F.; Jeong, E.-K.; Parker, D.; Lu, Z.-R. Chinese J. Magn. Reson. 2011, 2, 325-330. (invited)
    • Synthesis and Evaluation of Nanoglobular Macrocyclic Mn(II) Chelate Conjugates as Non-Gadolinium(III) MRI Contrast Agents, Tan, M. Q.; Ye, Z.; Jeong, E. K.; Wu, X. M.; Parker, D. L.; Lu, Z. R. Bioconjugate Chemistry 2011, 22, 931-937.[Abstract]
    • Integrin Targeted MR Imaging, Tan, M. Q.; Lu, Z. R. Theranostics 2011, 1, 83-101.[Abstract]
    • Ocular Pharmacokinetic Study Using T(1) Mapping and Gd-Chelate- Labeled Polymers, Shi, X.; Liu, X.; Wu, X.; Lu, Z. R.; Li, S. K.; Jeong, E. K. Pharmaceutical Research 2011, 28, 3180-3188.[Abstract]

    Papers Published 2010

    • New Amphiphilic Carriers Forming pH-Sensitive Nanoparticles for Nucleic Acid Delivery, Xu, R. Z.; Wang, X. L.; Lu, Z. R. Langmuir 2010, 26, 13874-13882.[Abstract]
    • Synthesis and evaluation of nanoglobule-cystamine-(Gd-DO3A), a biodegradable nanosized magnetic resonance contrast agent for dynamic contrast-enhanced magnetic resonance urography, Xu, R.; Kaneshiro, T. L.; Jeong, E. K.; Parker, D. L.; Lu, Z. R. International Journal of Nanomedicine 2010, 5, 707-713.[Abstract]
    • Stability and Biodistribution of a Biodegradable Macromolecular MRI Contrast Agent Gd-DTPA Cystamine Copolymers (GDCC) in Rats, Wu, X. M.; Zong, Y. D.; Ye, Z.; Lu, Z. R. Pharmaceutical Research 2010, 27, 1390-1397.[Abstract]
    • Noninvasive Evaluation of Antianglogenic Effect in a Mouse Tumor Model by DCE-MRI with Gd-DTPA Cystamine Copolymers, Wu, X. M.; Jeong, E. K.; Emerson, L.; Hoffman, J.; Parker, D. L.; Lu, Z. R. Molecular Pharmaceutics 2010, 7, 41-48.[Abstract]
    • An Effective Targeted Nanoglobular Manganese(II) Chelate Conjugate for Magnetic Resonance Molecular Imaging of Tumor Extracellular Matrix, Tan, M. Q.; Wu, X. M.; Jeong, E. K.; Chen, Q. J.; Parker, D. L.; Lu, Z. R. Molecular Pharmaceutics 2010, 7, 936-943.[Abstract]
    • Peptide-Targeted Nanoglobular Gd-DOTA Monoamide Conjugates for Magnetic Resonance Cancer Molecular Imaging, Tan, M. Q.; Wu, X. M.; Jeong, E. K.; Chen, Q. J.; Lu, Z. R. Biomacromolecules 2010, 11, 754-761.[Abstract]
    • Polydisulfide-based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents, Lu, Z. R.; Wu, X. M. Israel Journal of Chemistry 2010, 50, 220-232.[Abstract]
    • Molecular imaging of HPMA copolymers: Visualizing drug delivery in cell, mouse and man, Lu, Z. R. Advanced Drug Delivery Reviews 2010, 62, 246-257.[Abstract]
    • Rapid simultaneous acquisition of T(1) and T(2) mapping images using multishot double spin-echo EPI and automated variations of TR and TE (ms-DSEPI-T12), Liu, X.; Feng, Y.; Lu, Z. R.; Morrell, G.; Jeong, E. K. Nmr in Biomedicine 2010, 23, 97-104. [Abstract]

    Papers Published 2009

    • Structural effect on degradability and in vivo contrast enhancement of polydisulfide Gd(III) complexes as biodegradable macromolecular MRI contrast agents, Zong, Y. D.; Wang, X. L.; Jeong, E. K.; Parker, D. L.; Lu, Z. R. Magnetic Resonance Imaging 2009, 27, 503-511. [Abstract]
    • Tumor Characterization with Dynamic Contrast Enhanced Magnetic Resonance Imaging and Biodegradable Macromolecular Contrast Agents in Mice, Wu, X. M.; Feng, Y.; Jeong, E. K.; Emerson, L.; Lu, Z. R. Pharmaceutical Research 2009, 26, 2202-2208. [Abstract]
    • Targeted Systemic Delivery of a Therapeutic siRNA with a Multifunctional Carrier Controls Tumor Proliferation in Mice, Wang, X. L.; Xu, R. Z.; Wu, X. M.; Gillespie, D.; Jensen, R.; Lu, Z. R. Molecular Pharmaceutics 2009, 6, 738-746. [Abstract]
    • A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery, Wang, X. L.; Xu, R. Z.; Lu, Z. R. Journal of Controlled Release 2009, 134, 207-213. [Abstract]
    • Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier, Kaneshiro, T. L.; Lu, Z. R. Biomaterials 2009, 30, 5660-5666. [Abstract]
    • Application of a Biodegradable Macromolecular Contrast Agent in Dynamic Contrast-Enhanced MRI for Assessing the Efficacy of Indocyanine Green-Enhanced Photothermal Cancer Therapy, Feng, Y.; Emerson, L.; Jeong, E. K.; Parker, D. L.; Lu, Z. R. Journal of Magnetic Resonance Imaging 2009, 30, 401-406. [Abstract]

    Papers Published 2008

    • A Peptide Targeted Contrast Agent Specific to Fibrin-Fibronectin Complexes for Cancer Molecular Imaging with MRI, Ye, F. R.; Jeong, E. K.; Jia, Z. J.; Yang, T. X.; Parker, D.; Lu, Z. R. Bioconjugate Chemistry 2008, 19, 2300-2303. [Abstract]
    • A multifunctional and reversibly polymerizable carrier for efficient siRNA delivery, Wang, X. L.; Nguyen, T.; Gillespie, D.; Jensen, R.; Lu, Z. R. Biomaterials 2008, 29, 15-22. [Abstract]
    • Contrast-Enhanced MRI-Guided Photodynamic Cancer Therapy with a Pegylated Bifunctional Polymer Conjugate, Vaidya, A.; Sun, Y. G.; Feng, Y.; Emerson, L.; Jeong, E. K.; Lu, Z. R. Pharmaceutical Research 2008, 25, 2002-2011. [Abstract]
    • Synthesis and Evaluation of Globular Gd-DOTA-Monoamide Conjugates with Precisely Controlled Nanosizes for Magnetic Resonance Angiography, Kaneshiro, T. L.; Jeong, E. K.; Morrell, G.; Parker, D. L.; Lu, Z. R. Biomacromolecules 2008, 9, 2742-2748. [Abstract]
    • Characterization of Tumor Angiogenesis With Dynamic Contrast-Enhanced MRI and Biodegradable Macromolecular Contrast Agents in Mice, Feng, Y.; Jeong, E. K.; Mohs, A. M.; Emerson, L.; Lu, Z. R. Magnetic Resonance in Medicine 2008, 60, 1347-1352. [Abstract]

    Papers Published 2007

    • In vivo evaluation of a PAMAM-Cystamine-(Gd-DO3A) conjugate as a biodegradable macromolecular MRI contrast agent, Xu, R. Z.; Wang, Y. L.; Wang, X. L.; Jeong, E. K.; Parker, D. L.; Lu, Z. R. Experimental Biology and Medicine 2007, 232, 1081-1089. [Abstract]
    • Noninvasive visualization of pharmacokinetics, biodistribution and tumor targeting of poly[N-(2-hydroxypropyl)methacrylamide] in mice using contrast enhanced MRI, Wang, Y. L.; Ye, F. R.; Jeong, E. K.; Sun, Y.; Parker, D. L.; Lu, Z. R. Pharmaceutical Research 2007, 24, 1208-1216. [Abstract]
    • Novel polymerizable surfactants with pH-sensitive amphiphilicity and cell membrane disruption for efficient siRNA delivery, Wang, X. L.; Ramusovic, S.; Nguyen, T.; Lu, Z. R. Bioconjugate Chemistry 2007, 18, 2169-2177. [Abstract]
    • A novel environment-sensitive biodegradable polydisulfide with protonatable pendants for nucleic acid delivery, Wang, X. L.; Jensen, R.; Lu, Z. R. Journal of Controlled Release 2007, 120, 250-258. [Abstract]
    • Conjugation of poorly absorptive drugs with mucoadhesive polymers for the improvement of oral absorption of drugs, Sakuma, S.; Matsumoto, T.; Yamashita, S.; Wang, Y.; Lu, Z. R. Journal of Controlled Release 2007, 123, 195-202. [Abstract]
    • Modification of Gd-DTPA cystine copolymers with PEG-1000 optimizes pharmacokinetics and tissue retention for magnetic resonance angiography, Mohs, A. M.; Nguyen, T.; Jeong, E. K.; Feng, Y.; Emerson, L.; Zong, Y. D.; Parker, D. L.; Lu, Z. R. Magnetic Resonance in Medicine 2007, 58, 110-118. [Abstract]
    • Gadolinium(III)-based blood-pool contrast agents for magnetic resonance imaging: status and clinical potential, Mohs, A. M.; Lu, Z. R. Expert Opinion on Drug Delivery 2007, 4, 149-164. [Abstract]
    • Polymer platforms for drug delivery and biomedical imaging, Lu, Z. R.; Ye, F. R.; Vaidya, A. Journal of Controlled Release 2007, 122, 269-277. [Abstract]
    • Application of biomedical imaging in drug discovery and development, Lu, Z. R. Pharmaceutical Research 2007, 24, 1170-1171. [Abstract]
    • RGD targeted poly(L-glutamic acid)-cystamine-(Gd-DO3A) conjugate for detecting angiogenesis biomarker alpha(v)beta(3) integrin with MRT1 mapping, Ke, T. Y.; Jeong, E. K.; Wang, X. L.; Feng, Y.; Parker, D. L.; Lu, Z. R. International Journal of Nanomedicine 2007, 2, 191-199. [Abstract]
    • Synthesis, characterization, and gene delivery of Poly-L-lySine octa(3-aminopropyl)silsesquioxane dendrimers: nanoglobular drug carriers with precisely defined molecular Architectures, Kaneshiro, T. L.; Wang, X.; Lu, Z. R. Molecular Pharmaceutics 2007, 4, 759-768. [Abstract]
    • Biodistribution and phannacokinetics of colon-specific HPMA copolymer-9-aminocamptothecin conjugate in mice, Gao, S. Q.; Lu, Z. R.; Kopeckova, P.; Kopecek, J. Journal of Controlled Release 2007, 117, 179-185. [Abstract]

    Papers Published 2006

    • Effect of size and charge on pharmacokinetics enhancement of biodegradable and in vivo MRI contrast polydisulfide Gd(III) complexes, Zong, Y.; Guo, J.; Ke, T.; Mohs, A. M.; Parker, D. L.; Lu, Z. R. Journal of Controlled Release 2006, 112, 350-356. [Abstract]
    • Noninvasive visualization of in vivo drug delivery of poly(L-glutamic acid) using contrast-enhanced MRI, Ye, F. R.; Ke, T. Y.; Jeong, E. K.; Wang, X. L.; Sung, Y. G.; Johnson, M.; Lu, Z. R. Molecular Pharmaceutics 2006, 3, 507-515. [Abstract]
    • Contrast-enhanced magnetic resonance angiography with biodegradable (Gd-DTPA)-cystamine copolymers: Comparison with MS-325 in a swine model, Nguyen, T. D.; Spincemaille, P.; Vaidya, A.; Prince, M. R.; Lu, Z. R.; Wang, Y. Molecular Pharmaceutics 2006, 3, 558-565. [Abstract]
    • Polydisulfide Gd(III) chelates as biodegradable macromolecular magnetic resonance imaging contrast agents, Lu, Z. R.; Mohs, A. M.; Zong, Y.; Feng, Y. International Journal of Nanomedicine 2006, 1, 31-40. [Abstract]
    • What can you see with imaging in pharmaceutical research?, Lu, Z. R. Molecular Pharmaceutics 2006, 3, 471-471. [Abstract]
    • Biodegradable cystamine spacer facilitates the clearance of Gd(III) chelates in poly(glutamic acid) Gd-DO3A conjugates for contrast-enhanced MR imaging, Ke, T. Y.; Feng, Y.; Guo, J. Y.; Parker, D. L.; Lu, Z. R. Magnetic Resonance Imaging 2006, 24, 931-940. [Abstract]
    • Gd-DTPA L-cystine bisamide copolymers as novel biodegradable macromolecular contrast agents for MR blood pool imaging, Kaneshiro, T. L.; Ke, T.; Jeong, E. K.; Parker, D. L.; Lu, Z. R. Pharmaceutical Research 2006, 23, 1285-1294. [Abstract]
    • Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer, Gao, S. Q.; Lu, Z. R.; Petri, B.; Kopeckova, P.; Kopecek, J. Journal of Controlled Release 2006, 110, 323-331. [Abstract]
    • Pharmacokinetics, biodistribution and contrast enhanced MR blood pool imaging of Gd-DTPA cystine copolymers and Gd-DTPA cystine diethyl ester copolymers in a rat model, Feng, Y.; Zong, Y. D.; Ke, T. Y.; Jeong, E. K.; Parker, D. L.; Lu, Z. R. Pharmaceutical Research 2006, 23, 1736-1742. [Abstract]

    Papers Published 2005

    • Contrast-enhanced MRI with new biodegradable macromolecular Gd(III) complexes in tumor-bearing mice, Zong, Y. D.; Wang, X. H.; Goodrich, K. C.; Mohs, A. M.; Parker, D. L.; Lu, Z. R. Magnetic Resonance in Medicine 2005, 53, 835-842. [Abstract]
    • Pharmacokinetics and tissue retention of (Gd-DTPA)-cystamine copolymers, a biodegradable macromolecular magnetic resonance imaging contrast agent, Wang, X. H.; Feng, Y.; Ke, T. Y.; Schabel, M.; Lu, Z. R. Pharmaceutical Research 2005, 22, 596-602. [Abstract]
    • PEG-g-poly(GdDTPA-co-L-cystine): Effect of PEG chain length on in vivo contrast enhancement in MRI, Mohs, A. M.; Zong, Y. D.; Guo, J. Y.; Parker, D. L.; Lu, Z. R. Biomacromolecules 2005, 6, 2305-2311. [Abstract]

    Papers Published 2004

    • PEG-g-poly(GdDTPA-co-L-cystine): A biodegradable macromolecular blood pool contrast agent for MR imaging, Mohs, A. M.; Wang, X. H.; Goodrich, K. C.; Zong, Y. D.; Parker, D. L.; Lu, Z. R. Bioconjugate Chemistry 2004, 15, 1424-1430. [Abstract]
    • Extracellular biodegradable macromolecular gadolinium(III) complexes for MRI, Lu, Z. R.; Parker, D. L.; Goodrich, K. C.; Wang, X. H.; Dalle, J. G.; Buswell, H. R. Magnetic Resonance in Medicine 2004, 51, 27-34. [Abstract]

    Papers Published 2003

    • Poly(L-glutamic acid) Gd(III)-DOTA conjugate with a degradable spacer for magnetic resonance imaging, Lu, Z. R.; Wang, X. H.; Parker, D. L.; Goodrich, K. C.; Buswell, H. R. Bioconjugate Chemistry 2003, 14, 715-719. [Abstract]
    • Polymerizable Fab' antibody fragment targeted photodynamic cancer therapy in nude mice, Lu, Z. R.; Shiah, J. G.; Kopeckova, P.; Kopecek, J. Stp Pharma Sciences 2003, 13, 69-75. [Abstract]
    • Antigen responsive hydrogels based on polymerizable antibody Fab ' fragment, Lu, Z. R.; Kopeckova, P.; Kopecek, J. Macromolecular Bioscience 2003, 3, 296-300. [Abstract]

    Papers Published 2002

    • N-(2-hydroxypropyl)-methacrylamide copolymer-9-aminocamptothecin conjugate: Colon-specific drug delivery in rats, Sakuma, S.; Lu, Z. R.; Pecharova, B.; Kopeckova, P.; Kopecek, J. Journal of Bioactive and Compatible Polymers 2002, 17, 305-319. [Abstract]
    • Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates, Luo, Y.; Bernshaw, N. J.; Lu, Z. R.; Kopecek, J.; Prestwich, G. D. Pharmaceutical Research 2002, 19, 396-402. [Abstract]
    • Design of novel bioconjugates for targeted drug delivery, Lu, Z. R.; Shiah, J. G.; Sakuma, S.; Kopeckova, P.; Kopecek, J. Journal of Controlled Release 2002, 78, 165-173. [Abstract]
    • Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates, Kasuya, Y.; Lu, Z. R.; Kopeckova, P.; Tabibi, S. E.; Kopecek, J. Pharmaceutical Research 2002, 19, 115-123. [Abstract]

    Papers Published 2001

    • Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo, Varticovski, L.; Lu, Z. R.; Mitchell, K.; de Aos, I.; Kopecek, J. Journal of Controlled Release 2001, 74, 275-281. [Abstract]
    • Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin, Sakuma, S.; Lu, Z. R.; Kopeckova, P.; Kopecek, J. Journal of Controlled Release 2001, 75, 365-379. [Abstract]
    • Preparation and biological evaluation of polymerizable antibody Fab ' fragment targeted polymeric drug delivery system, Lu, Z. R.; Shiah, J. G.; Kopeckova, P.; Kopecek, J. Journal of Controlled Release 2001, 74, 263-268. [Abstract]
    • Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers, Lu, Z. R.; Gao, S. Q.; Kopeckova, P.; Kopecek, J. Bioconjugate Chemistry 2001, 12, 129-133. [Abstract]
    • Water soluble polymers in tumor targeted delivery, Kopecek, J.; Kopeckova, P.; Minko, T.; Lu, Z. R.; Peterson, C. M. Journal of Controlled Release 2001, 74, 147-158. [Abstract]
    • Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates, Kasuya, Y.; Lu, Z. R.; Kopeckova, P.; Minko, T.; Tabibi, S. E.; Kopecek, J. Journal of Controlled Release 2001, 74, 203-211. [Abstract]
    • Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems, Kasuya, Y.; Lu, Z. R.; Kopeckova, P.; Kopecek, J. Bioorganic & Medicinal Chemistry Letters 2001, 11, 2089-2091. [Abstract]

    Papers Published 2000

    • Synthesis of bioadhesive lectin-HPMA copolymer- cyclosporin conjugates, Lu, Z. R.; Gao, S. Q.; Kopeckova, P.; Kopecek, J. Bioconjugate Chemistry 2000, 11, 3-7. [Abstract]
    • HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action, Kopecek, J.; Kopeckova, P.; Minko, T.; Lu, Z. R. European Journal of Pharmaceutics and Biopharmaceutics 2000, 50, 61-81. [Abstract]
    • Polymerizable Fab ' antibody fragments for targeting of anticancer drugs, Lu, Z. R.; Kopeckova, P.; Kopecek, J. Nature Biotechnology 1999, 17, 1101-1104. [Abstract]