An automated computational image analysis pipeline for histological grading of cardiac allograft rejection.

TitleAn automated computational image analysis pipeline for histological grading of cardiac allograft rejection.
Publication TypeJournal Article
Year of Publication2021
AuthorsPeyster, EG, Arabyarmohammadi S, Janowczyk A, Azarianpour-Esfahani S, Sekulic M, Cassol C, Blower L, Parwani A, Lal P, Feldman MD, Margulies KB, Madabhushi A
JournalEuropean heart journal
Date Published2021 May 13
ISSN1522-9645
Abstract

Allograft rejection is a serious concern in heart transplant medicine. Though endomyocardial biopsy with histological grading is the diagnostic standard for rejection, poor inter-pathologist agreement creates significant clinical uncertainty. The aim of this investigation is to demonstrate that cellular rejection grades generated via computational histological analysis are on-par with those provided by expert pathologists.

DOI10.1093/eurheartj/ehab241
PDF Link

http://www.ncbi.nlm.nih.gov/pubmed/33982079?dopt=Abstract

Alternate JournalEur Heart J

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