On March 2nd, a patent was awarded to inventors from the Center for Computational Imaging and Personalized Diagnostics (CCIPD): “Predicting outcome in invasive breast cancer from collagen fiber orientation disorder features in tumor associated stroma”. Congratulations to Haojia Li, graduate student, biomedical engineering and CCIPD; and Anant Madabhushi, PhD, Donnell Institute Professor, biomedical engineering, and director of CCIPD. Read details about the patent below.
United States Serial Number (USSN): 10,937,159, March 2, 2021.
Inventors: Madabhushi; Anant, Li; Haojia
Abstract: Embodiments discussed herein relate to accessing a digitized image associated with a patient of tissue demonstrating breast cancer pathology; segmenting a tumor region represented in the digitized image; segmenting collagen fibers represented in the tumor region; computing collagen vectors based on the segmented collagen fibers; generating an orientation co-occurrence matrix based on the collagen vectors; computing a collagen fiber orientation disorder feature based on the co-occurrence matrix; upon determining that the collagen fiber orientation feature exceeds a threshold value: generating a prognosis of the region of tissue as unlikely to experience breast cancer recurrence; upon determining that the collagen fiber orientation feature is less than or equal to the threshold value: generating a prognosis of the region of tissue as likely to experience breast cancer recurrence; classifying the patient as high-risk of recurrence or low-risk of recurrence based, at least in part, on the prognosis; and displaying the classification.
