OBL has been regularly publishing in first tier journals such as Journal of Biomechanics, BONE, Journal of Bone and Mineral Research, Biomaterials, and Journal of Orthopaedic Research. Key findings of his several publications have been highlighted in Nature Materials, Nature Photonics and textbooks such as Mechanical Design in Organisms.

Chapters in Books and Proceedings

1. Akkus O, Rimnac CM and Guran A (2006): A Micromechanical Model for the Prediction of Microcracking Induced Elastic Property Degradation in Human Cortical Bone Tissue, Chapter 10, in Advances in Continuum Mechanics in the "Series on Stability, Vibration and Control of Systems" (Guran A, Smirnov A and Steigmann D eds), World Scientific Publishers.

2. Karl J. Jepsen, Dwight T. Davy, Ozan Akkus, Observations of Damage in Bone, In Bone Mechanics / editor: Stephen C. Cowin, Boca Raton, Fla. 2001.

3. Yerramshetty JS, Akkus O: (2012): “Age- and Osteoporosis- related changes in bone mineral”, In Skeletal Aging and Osteoporosis: Biomechanics and Mechanobiology, Edited by Matthew Silva and Edward X. Guo. (in print).

4. Burr DB, Allen MA, Akkus O: (2012): “Bone Morphology”, In Basic Applied Bone Biolog, Edited by Burr DB and Allen MA. (in preparation).

Patents

1. Acoustic Emission-Based Method and Apparatus for Monitoring Bone Damage, 60/683,025 filed on May 20, 2005.

2. ALIGNED COLLAGEN AND METHOD THEREFOR, 12/745,362, U.S. Patent Application, 5/28/2010.

3. System and Method for Prevention of Hypertrophic Scars by Actuatable Patch, PCT2011/163673, 29 December 2011.

Journal Articles

• Biomaterials, Tissue Engineering and Biofabrication

1. Reich MS, Akkus O, Sporicidal efficacy of genipin: a potential theoretical alternative for biomaterial and tissue graft sterilization, Cell and Tissue Banking, in revision.

2. Uquillas JA, Kishore V, Akkus O, Optimization of Crosslinking Conditions Enhances the Mechanical Properties and Cellular Compatibility of Tissue Mimicking Collagenous Matrices, Journal of Mechanical Behavior of Biomedical Materials, accepted.

3. Akhilesh K. Gaharwar, Vipuil Kishore, Christian Rivera, Whitney Bullock, Chia-Jung, Wu, Ozan Akkus, Gudrun Schmidt, Physically Cross-linked Nanocomposites from Silicate Cross-linked Poly(ethylene oxide): Mechanical Properties and Osteogenic Differentiation of Human Mesenchymal Stem Cells, Macromolecular Bioscience, in press.

4. Uquillas J.A. and Akkus O., Modeling the electromobility of type-I collagen molecules in the electrochemical fabrication of dense and aligned tissue constructs, Annals of Biomedical Engineering, V40, 1641-1653 2012.

5. Umut Atakan Gurkan, Ryan Golden, Vipuil Kishore, Catherine Riley, Jiri Adamec, and Ozan Akkus, Proteomic profiling of inherently ossifying bone marrow, Clinical Orthopaedics and Related Research, 2012, accepted.

6. Kishore, V., Uquillas, J.A., Dubikovsky, A., Alshehabat, M., Snyder, P., Breur, G.J., Akkus, O., In vivo response to electrochemically aligned collagen bioscaffolds. J Biomed Mater Res B Appl Biomater, Volume 100B, Issue 2, pages 400-408 2012.

7. Kishore V, Bullock W, Sun X, Van Dyke WS, Akkus O, Tenogenic differentiation of human MSCS induced by the topography of electrochemically aligned collagen threads. Biomaterials, 33(7):2137-44, 2012.

8. Uquillas JA, Kishore V and Akkus O, Effects of phosphate-buffered saline concentration and incubation time on the mechanical and structural properties of electrochemically aligned collagen threads, Biomedical Materials, Volume 6, Issue 3, 2011.

9. Kishore V, Paderi JE, Akkus A, Smith KM, Balachandran D, Beaudoin S, Panitch A, Akkus O, Incorporation of a decorin biomimetic enhances the mechanical properties of electrochemically aligned collagen threads, Acta Biomater. Jun;7(6):2428-36. 2011.

10. Gurkan UA, Krueger A, Akkus O, Mechanical Stimulation Enhances the Production of VEGF, IGF-1 and TGF-b1 by In Vitro Ossifying Bone Marrow Explants, accepted, Tissue Engineering, Part A, 2010.

11. Gaharwar AK, Schexnailder P., Kaul V., Akkus O., Zakharov D., Seifert S. and Schmidt G., Highly extensible bio-nanocomposite films with direction dependent properties, Advanced Functional Materials, Volume 20 Issue 3, Pages 429 – 436, 2010.

12. Gurkan UA, Gargac J, Akkus O, The Sequential Expression Profiles of Growth Factors and Their Relations to Bone Volume in Ossifying Bone Marrow Explants, Tissue Engineering, Part A. 16(7): 2295-2306, 2010.

13. Gurkan UA, Kishore, Cheng X, Uquillas JA, Akkus O, Comparison of Morphology, Orientation, and Migration of Tendon Derived Fibroblasts and Bone Marrow Stromal Cells on Electrochemically Aligned Collagen Constructs, Journal of Biomedical Materials Research, 94A (4): 1070-1079, 2010.

14. Diegmueller J, Cheng X, Akkus O., Modulation of Hydroxyapatite Nanocrystal Size and Shape by Polyelectrolytic Peptides, Crystal Growth and Design, 9(12):5220–5226, 2009.

15. Gurkan UA and Akkus O, Mechanical environment of bone marrow: A review, Annals of Biomedical Engineering, Dec;36(12):1978-91, 2008.

16. Cheng X., Gurkan UA, Dehen CJ, Tate MP, Hillhouse HW, Simpson HW and Akkus O., An electrochemical process for assembly of anisotropically oriented collagen bundles, Biomaterials, 29(22): 3278-88, 2008.

17. Kattaya SA, Akkus O, Slama J, Effect of radioprotectants and radiosensitizers on the sterility of gamma irradiated bone, Clinical Orthopaedics and Related Research, 466:1796-1803, 2008.

18. Dziak KL and Akkus O, Effects of Polyelectrolytic Peptides on the Quality of Mineral Crystals Grown In Vitro, Journal of Bone and Mineral Metabolism, 26(6):569-75, 2008.

19. Das P, Akkus O, and Azad AM, Optimization of the Mineral Content in Polymeric Gels: The Effect of Calcium to Phosphate Molar Ratio, Journal of Crystal Growth, 280 (3-4): 587-593 2005.

20. Gursel, I., Balcik, C., Arica, Y., Akkus, O., Akkas N., Hasirci, V., Synthesis and mechanical properties of interpenetrating networks of polyhydroxybutyrate-co-hydroxyvalerate and polyhydroxyethyl methacrylate, Biomaterials, 19: (13) 1137-1143 JUL 1998.

21. Komurcu, M., Akkus, O., Basbozkurt, M., Gur, E., and Akkas, N., Reduction of Restrictive Adhesions by Local Aprotinin Application and Primary Sheath Repair in Surgically Traumatized Flexor Tendons of the Rabbit, The Journal of Hand Surgery, 1997, 22A:826-832.

 

• Biomedical Optics

1. Song Q, Xu Z, Choi SH, Sun X, Xiao S, Akkus O, and Kim YL, Detection of nanoscale structural changes in bone using random lasers, Biomedical Optics Express, 1(5): 1401–1407, 2010.

2. Z. Xu, X. Sun, J. Liu, Q. Song, M. Muckley, O. Akkus, and Y.L. Kim, "Spectroscopic visualization of nanoscale deformation in bone: interaction of light with partially disordered nanostructure", Journal of Biomedical Optics, 15(6):060503, 2010.

3. Q. Song, S. Xiao, Z. Xu, J. Liu, X. Sun, V. Drachev, V. M. Shalaev, O. Akkus, Y.L. Kim, Random lasing in bone tissue, Optics Letters, Vol. 35, Issue 9, pp. 1425-1427 (2010) ("Bony emission", Research Highlights, Nature Photonics 4, 408-409, 2010.).

4. Cheng X., Haggins DG, York RH, Yeni YN, Akkus O, Diagnosis of Crystals Leading to Joint Arthropathies by Raman Spectroscopy: Comparison with Compensated Polarized Imaging, Applied Spectroscopy, 63(4):381-6, 2009.

5. Ishwar AR, Jeong KJ, Panitch A, Akkus O, Raman Spectroscopic Investigation of GAG-Peptide Interactions, Applied Spectroscopy, 63(6):636-41, 2009

6. Nandagawali ST and Akkus O, Identification of Chemical Species in Biodegradable Implants by Raman Microscopy, Journal of Biomedical Materials Research, 82(3):611-7, 2007.

7. Yeni YN, Yerramshetty JS, Akkus O, Pechey C and Les CM, Effect of Fixation and Embedding on Raman Spectroscopic Analysis of Bone Tissue, Calcified Tissue International, 78(6)-363-371, 2006.

 

• Biomechanics and Mechanobiology

1. Zhong Z, Muckley, M, Agcaoglu S, Grisham M; Zhao H, Orth M, Lilburn M, Karcher D, Akkus O, The Effects of Selective Breeding for Body Weight on Morphological and Material Level Mechanical Properties in Turkey Femurs, Poultry Science, in revision.

2. Dodge T, Wanis M, Ayoub R, Zhao L, Watts NB, Bhattacharya A, Akkus O, Robling A, Yokota H,  Mechanical Loading, Damping, and Load-Driven Bone Formation in Mouse Tibiae, BONE, accepted.

3. Sun X., Kishore V., Fites K., Akkus O., Osteoblasts Detect Pericellular Calcium Concentration Increase via Neomycin-Sensitive Voltage Gated Calcium Channels, BONE, in revision.

4. Agcaoglu S., Akkus O., Acoustic Emission Based Monitoring of the Microdamage Evolution During Fatigue of Human Cortical Bone, Journal of Mechanical Behavior of Biomedical Materials, submitted.

5. Van Dyke WS, Sun X., Richard B, Nauman EA, Akkus O, Novel Mechanical Bioreactor Capable of Concomitant Fluid Shear Stress and Substrate Strain, Short Communication, Journal of Biomechanics, Volume 45, Issue 7, 30 April 2012, Pages 1323-1327.

6. Sun X, McLamore ES, Kishore V, Fites K, Porterfield DM, Akkus O, Calcium Efflux from Bone Matrix as a Potential Mechanotransduction Signal to Bone Cells, BONE, Volume 50, Issue 3, pages 581-591, 2012.

7. Zhong Z., Akkus O., Effects of age and shear rate on the rheological properties of human yellow bone marrow, Biorheology, 48(2), 89-97, 2011.

8. Gurkan UA, Kishore V, Condon KW, Bellido TM, Akkus O, Characterization of inherently ossifying bone marrow explant culture as a scaffold free multicellular three dimensional in vitro model of osteogenesis, Calcified Tissue International, 88(5):388-401, 2011.

9. Schilt PN, McRae BR, Akkus O, Cordes SR, Halum SL, An Experimental Model to Evaluate Tracheal Anastomosis Strength, The Laryngoscope, Volume 120 Issue 6, Pages 1125 – 1128, 2010.

10. Sun X, Jeon JH, Blendell J, Akkus O, Visualization of a Phantom Post-Yield Deformation Process in Cortical Bone. Journal of Biomechanics, 1997-2001, Volume 43, 2010.

11. Wasserman N, Brydges B, Searles S, Akkus O, In Vivo Linear Microcracks of Human Femoral Cortical Bone Remain Parallel to Osteons during Aging, BONE, 43: 856-861, 2008.

12. Yerramshetty JS and Akkus O,The associations between mineral crystallinity and the mechanical properties of human cortical bone, BONE, 42(3):476-82, 2007.

13. Ramasamy JG, Akkus O, Local variations in the micromechanical properties of mouse femur: The involvement of collagen fiber orientation and mineralization, Journal of Biomechanics, 40: 910-918, 2007.

14. Yerramshetty JS, Lind C., and Akkus O, The Compositional and Physicochemical Homogeneity of Male Femoral Cortex Increases after the Sixth Decade, BONE, 39 (6): 1236-1243 2006.

15. Akkus O, Elastic Deformation of Mineralized Collagen Fibrils: An Equivalent Inclusion Based Composite Model, Journal of Biomechanical Engineering, 127 (3): 383-390 2005.

16. Akkus O, Belaney RM, Das P., Free Radical Scavenging Alleviates the Biomechanical Impairment of Gamma Radiation Sterilized Bone Tissue, Journal of Orthopaedic Research, 23 (4): 838-845 2005.

17. Akkus O and Belaney RM, Sterilization by Gamma Radiation Impairs the Fatigue Life of Cortical Bone by Two Orders of Magnitude, Journal of Orthopaedic Research, 23(5):1054-8 2005.

18. Wasserman N, Yerramshetty J and Akkus O., In Vivo Microcracks Colocalize within Highly Mineralized Regions of Cortical Bone Tissue. European Journal of Morphology, 42(1-2):43-51 2005.

19. Akkus O, Yeni YN, Wasserman N, Fracture Mechanics of Cortical Bone Tissue: A Hierarchical Perspective, Critical Reviews in Biomedical Engineering, 32(5-6):379-426, 2004.

20. Akkus O, Adar F., Schaffler M.B., Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone, Bone, 34:443-453, 2003.

21. Akkus O, Polyakova-Akkus A., Adar F., Schaffler M.B., Aging of Microstructural Compartments in Human Compact Bone, Journal of Bone and Mineral Research, 18: 1012-1019, 2003.

22. Jepsen KJ, Akkus O, Majeska RJ, Nadeau JH, Hierarchical relationship between bone traits and mechanical properties in inbred mice, Mammalian Genome, 14: 97-104, 2003.

23. Akkus O, Knott D.F., Jepsen K.J., Davy D.T., Rimnac C.M., The Relationship Between Damage Accumulation and Mechanical Property Degradation in Bone: Microcrack Orientation Is Important, Journal of Biomedical Materials Research, 65A:482-488, 2003.

24. Akkus O, Comments on acoustic emission visualization of bone cement fatigue locations, Journal of Biomedical Materials Research, 59: 398-399, 2002.

25. Akkus O and Rimnac C.M., Cortical bone tissue resists fatigue fracture by deceleration and arrest of microcrack growth, Journal of Biomechanics. 34: 757-764, 2001.

26. Akkus O and Rimnac C.M., Fracture Resistance of Gamma Radiation Sterilized Cortical Bone Allografts, Journal of Orthopaedic Research. 19: 927-934, 2001.

27. Akkus O, Jepsen K.J., and Rimnac C.M., Microstructural Aspects of The Fracture Process in Human Cortical Bone, Journal of Materials Science, 35:6065-6074, 2000.

28. Korkusuz F, Akin S, Akkus O, Korkusuz P. Assessment of mineral density and atomic content of fracture callus by quantitative computerized tomography. Journal of Orthopaedic Science 5(3):248-255 2000.

29. Akkus, O., Korkusuz, F., Korkusuz, P., Akin, S., and Akkas, N., Evaluation of Fracture Healing in Rabbit Tibia: A Comparison of Biomechanical Methods with Bone Density Measurements by QCT and Histology, Journal of Engineering in Medicine-Proceedings of the Institution of Mechanical Engineers - Part H, 1998, 212:327-336.

30. Omeroglu, H., Ates, Y., Akkus, O., Korkusuz, F., Bicimoglu, A., and Akkas, N., Biomechanical Analysis of the Effects of Single High Dose Vitamin D3 on Fracture Healing in a Healthy Rabbit Model, Archives of Orthopaedic and Trauma Surgery, 1997, 116:271:274.

31. Birlik G., Korkusuz F., Akkus O., Akkas, N.,: Assessment of Spinal Implants Under Cyclic Loading, Journal of Turkish Spinal Surgery, V4, No3, 1993.

Abstracts

1. Kishore V, Bullock W, Sun X, Van Dyke WS, Akkus O, TISSUE MIMICKING DENSE ALIGNED COLLAGEN INDUCES TENOGENIC DIFFERENTIATION OF HUMAN MSCs, European Society of Biomechanics, July 1-4 2012, Lisbon Portugal. (winner of the best poster award among ~200 posters)

2. Sun X., Kishore V., Fites K., Akkus O, MECHANICAL STRETCH INDUCED CALCIUM EFFLUX FROM BONE MATRIX STIMULATES OSTEOBLASTS European Society of Biomechanics, July 1-4 2012, Lisbon Portugal.

3. Wang, B; Li, W; Sun X; Akkus, O; Wang L, Do microcracks influence solute transport in osteocyte lacunar-canalicular system? Orthopaedic Research Society Meeting, San Francisco. 2012.

4. Kishore V., Bullock, W., Sun, X., Akkus, O.; Substrate Topography Induced Tenogenic Differentiation of Human Mesenchymal Stem Cells, TERMIS-NA Meeting, December 11-14, Houston, Texas, 2011.

5. Kishore, V., Gaharwar, A.K., Pavalko, W., Akkus, O., Schmidt, G.; Osteogenic Differentiation of Human Mesenchymal Stem Cells on Silicate Cross-linked Poly(ethylene Oxide), Biomedical Engineering Society Annual Meeting: October 12-15, Hartford, Connecticut, 2011.

6. Kishore, V., Paderi J.E., Akkus, A., Panitch, A., Akkus, O.; Incorporation of a Decorin Biomimetic Enhances the Mechanical Properties of Electrochemically Aligned Collagen Threads, ASME Summer Bioengineering Conference, June 22-25, Farmington, Pennsylvania, 2011.

7. Sun, X., Kishore, V., Fites, K., Akkus, O.; Mechanically Induced Calcium Release from Bone Matrix Triggers Intracellular Ca2+ Signaling in Osteoblasts, ASME Summer Bioengineering Conference, June 22-25, Farmington, Pennsylvania, 2011.

8. Van Dyke WS, Nauman EA, Akkus O; A Novel Mechanical Bioreactor System Allowing Simultaneous Strain and Fluid Shear Stress on Cell Monolayers, ASME Summer Bioengineering Conference, June 22-25, Farmington, Pennsylvania, 2011.

9. Sun X, Mclamore ES, Porterfield MD, Akkus O; Calcium Efflux from Bone Matrix in Response to Mechanical Loading, ASME Summer Bioengineering Conference, June 22-25, Farmington, Pennsylvania, 2011.

10. Uquillas JA; Akkus O, Modeling of Isoelectric focusing of type-I collagen molecules under uniform electric field, ASME Summer Bioengineering Conference, June 22-25, Farmington, Pennsylvania, 2011.

11. Muckley M. Agcaoglu S, Zhong Z, Zhao H, Grisham M, Karcher D, Orth M, Lilburn M, Akkus O, The Effect Of Selective Breeding For Body Weight On Geometric Properties In Turkey Femurs, ASME Summer Bioengineering Conference, June 22-25, Farmington, Pennsylvania, 2011.

12. Zhong Z, Agcaoglu S, Muckley M, Zhao H, Karcher D, Orth M, Lilburn M, Akkus O, Changes In Turkey Femora Mechanical Properties Resulting From Selective Breeding For Body Weight, ASME Summer Bioengineering Conference, June 22-25, Farmington, Pennsylvania, 2011.

13. Rickett, T., Kishore, V., Uquillas, J.A., Akkus, O., Shi, R.; A Nerve Tissue Scaffold of Electrochemically Aligned Fibers, National Neurotrauma Symposium, June 14-17, Las Vegas, Nevada, 2010.

14. Rickett, T., Kishore, V., Uquillas, J.A., Akkus, O., Shi, R.; Electrochemically Aligned Collagen Fibers as a Nerve Tissue Scaffold, Midwest Biomedical Engineering Conference, March 5, Cleveland, Ohio, 2010.

15. Sun, X; Jeon, JH; Blendell, J; Akkus, O, Molecular Deformation Mechanism in Cortical Bone Probed by Fluorescent dyes, European Society of Biomechanics, Edinburgh, Scotland, July 2010.

16. Sun, X; Jeon, JH; Blendell, J; Akkus, O, High Local Deformation Colocalized with Optical Changes in Cortical Bone under Tension, European Society of Biomechanics, Edinburgh, Scotland, July 2010.

17. Gurkan UA, Gargac J, Akkus O, The Effect of Mechanical Stimulation on the Production of BMP-2, VEGF, IGF-1 and TGF-b1 by In Vitro Ossifying Rat Bone Marrow Explants, European Society of Biomechanics, Edinburgh, Scotland, July 2010.

18. Sun, X; Jeon, JH; Blendell, J; Akkus, O, A Novel Prefailure Molecular Deformation Mechanism in Cortical Bone, Orthopaedic Research Society Meeting, New Orleans, March 2010.

19. Uquillas, JA.; Breur, GJ.; Akkus, O., Synthesis and Implantation of a Tissue-engineered Tendon in a Rabbit Model  - a preliminary study, 22nd European Conference on Biomaterials, Lausanne, Switzerland, September 2009.

20. Uquillas, JA.; Kishore, V.; Zhong, Z.; Breur, GJ.; Snyder, P.; Akkus, O., Electrochemically Aligned Collagen Scaffolds Induce Tendon Hyperthropy In Vivo, Biomaterials Day, Society for Biomaterials, Lexington, KY, September 2009.

21. Diegmueller, J; Sun, X; Cheng, XG; Akkus, O, Modulation of Hydroxyapatite Nanocrystal Growth and Morphology by Polyelectrolytic Peptides and Its Potential In Vivo Applications, Biomaterial Day, Lexington, September 2009.

22. Sun, X; Akkus, O, Miniaturized Portable Raman System for Clinical Diagnosis of Gout, The Federation of Analytical Chemistry and Spectroscopy Societies Conference, St Louis, October 2009.

23. Kishore V., U.A. Gurkan, J. A. Uquillas and O. Akkus, Comparison between the Migration Rates of Bone Marrow Stromal Cells and Tendon Derived Fibroblasts on Random and Electrochemically Aligned Collagen Constructs, Society for Biomaterials, Biomaterials Day, Lexington, Kentucky, September 2009.

24. Gurkan U. A., X. Cheng, O. Akkus, Migration of Tendon Derived Fibroblasts and Bone Marrow Stromal Cells on Electrochemically Aligned Collagen Constructs, The 15th International Biomedical Science and Technology Symposium, Middle East Technical University Northern Cyprus Campus, Turkish Republic of Northern Cyprus, August 2009.

25. Gurkan U. A., O. Akkus, In Vitro Ossifying Bone Marrow Explants Have Osteoinductive Potential via the Media Conditioned By Them, The 15th International Biomedical Science and Technology Symposium, Middle East Technical University Northern Cyprus Campus, Turkish Republic of Northern Cyprus, August 2009.

26. Gurkan U. A., A. Krueger and O. Akkus, Mechanical Stimulation Enhances the Production of Bmp-2 in Ossifying Rat Bone Marrow Organ Cultures,  ASME Summer Bioengineering Conference, Lake Tahoe, CA, June 2009.

27. Jeon, JH; Blendell, J; Akkus, O; On the Presence of Phantom Cracks in Bone Tissue, Orthopaedic Research Society Meeting, Las Vegas, February 2009.

28. Gurkan UA, Akkus O, The Osteoinductive Potential of Bone Marrow Conditioned Media is Superior to Dexamethasone and rhBMP-2 Orthopaedic Research Society Meeting, Las Vegas, February 2009.

29. Gurkan, UA.; Akkus, O; Meldrum, RD.; Kattaya, SA., Staphylococcus Aureus Inhibits the Osteogenesis Induced by Rat Pulmonary Alveolar Macrophages, Orthopaedic Research Society Meeting, Las Vegas, February 2009.

30. Cheng, XG; Haggins, D; Yeni, Y; Akkus, O, Raman-Based Identification of Crystals in Synovial Samples from Patients with Gouty Symptoms,   Orthopaedic Research Society Meeting, Las Vegas, February 2009.

31. Gurkan U, Akkus O, Facilitating the Exodus of Adherent Cells Improves In Vitro Bone Formation in Bone Marrow Explants, Orthopaedic Research Society Meeting, Las Vegas, February 2009.

32. Ishwar A, Jeong K, Panitch A, Akkus O, Raman Investigation of GAG Binding Peptide Interactions, Annual Meeting of the Biomedical Engineering Society, St. Louis MO, October 2008.

33. Gaharwar A, Schexnailder P, White J, Siefert S, Kaul V, Akkus O, Wilker J, Dundigalla 2, Schmidt G, Structural, Mechanical and Biological Properties of New Bio-Nanocomposite Fibers, Annual Meeting of the Biomedical Engineering Society, St. Louis MO, October 2008.

34. Kaul V, Akkus O, Real-Time, Noninvasive In Vitro Bone Health Monitoring, Annual Meeting of the Biomedical Engineering Society, St. Louis MO, October 2008.

35. Agcaoglu S, Kaul V, Akkus O, Feasibility of Portable Acoustic Emission Approach For Prognosis of Stress Fractures, ASME Summer Bioengineering Conference, Marco Island FL, June 2008.

36. Akkus O, and Sieving A, Laboratory Modules For Reinforcement of Concepts Taught in Undergraduate Tissue Mechanics Course, ASME Summer Bioengineering Conference, Marco Island FL, June 2008.

37. A.K. Gaharwar, V. Kaul, A. Dundigalla, O. Akkus, and G. Schmidt, Structure and mechanical properties of PEO-Laponite films made from gels, 235th American Chemical Society (ACS) National Meeting, April 6-10th 2008 at New Orleans, LA.

38. Cheng XG, Gurkan U, Uquillas JA, Akkus O, Feasibility of electrochemically aligned collagen bundles for ligament/tendon tissue engineering, International Society for Ligaments and Tendons Conference, 8^th Meeting, Palo Alto, CA. 2008.

39. Cheng, XG, Gurkan, UA, Akkus, O, Biomechanical Evaluation of Novel Electrochemically Synthesized Collagen Constructs for Tendon/Ligament Tissue Engineering, Orthopaedic Research Society Meeting, San Francisco, February 2008.

40.Diegmueller JJ, Akkus O., The influence of peptide size and charge on the its affinity for hydroxyapatite interfaces, Orthopaedic Research Society Meeting, San Francisco, February 2008.

41. Kaul V, Akkus O, Could Acoustic Emission Waves Emanating from Bone Microcracks be Detected In Vivo? Orthopaedic Research Society Meeting, San Francisco, February 2008.

42. Akkus O., Nandagawali S., Micropetrosis of osteocytes may be the outcome of secondary mineralization, International Bone and Mineral Society, Montreal, Canada, June 2007.

43. Xingguo Cheng, Nicholas Wasserman, Ozan Akkus, Improving the anisotropy of collagen by electric field increases its toughness by two-fold, ASME Summer Bioengineering Conference, Keystone CO, June 2007.

44. Pruden B., Akkus O., Measurement of acoustic emission wave attenuation by bones and muscles. ASME Summer Bioengineering Conference, Keystone CO, June 2007.

45. Gurkan, U., Akkus O, An implantable magnetoelastic sensor system for wireless physiological sensing of viscosity , ASME Summer Bioengineering Conference, Keystone CO, June 2007.

46. Diegmueller J., Akkus O., A practical method for real-time optical imaging of damage zone and microscale failure in bone, ASME Summer Bioengineering Conference, Keystone CO, June 2007.

47. Yerramshetty, J, Akkus, O, Can composition be used to predict the tensile fatigue life of cortical bone? Annual Meeting of the Orthopaedic Research Society, San Diego, CA February 2007.

48. Wasserman NW, Byrdges B, Searles Shane, Akkus O, The density and length of in vivo microcracks in cortical bone as viewed from the longitudinal direction, ASME Summer Bioengineering Conference, Amelia Island FL, June 2006.

49. Stammen KL, Akkus O, Lind C, Polyelectrolytes can modulate the shape and size of mineral crystals during in vitro mineralization, Annual Meeting of the Orthopaedic Research Society, Chicago, IL March 2006.

50. Nandagawali ST, Akkus O, Mineralization of the forming osteon is impeded along the radial direction, Annual Meeting of the Orthopaedic Research Society, Chicago, IL March 2006.

51. Wasserman NW, Akkus O, Qualitative investigation of the energistics of fatigue failure of cortical bone – an acoustic emission perspective, Annual Meeting of the Orthopaedic Research Society, Chicago, IL March 2006.

52. Yerramshetty JS, Akkus O, Mineral crystallinity and carbonation are correlates of the strength of human cortical bone, Annual Meeting of the Orthopaedic Research Society, Chicago, IL March 2006.

53. Yerramshetty JS, Akkus O, The relation between heterogeneity of mineralization and mechanical properties, Annual Meeting of the Orthopaedic Research Society, Chicago, IL March 2006.

54. Das P, Searles S, Akkus O: Raman Spectroscopy Can Identify Pathophysiological Joint Crystals at Clinical Concentrations, 52nd Annual Meeting of the Orthopaedic Research Society, Chicago, IL, March 2006.

55. Shuster MD, Akkus O, Slama JM, Akkus A, Novel Radioprotectants for Improving Sterility, Mechanics, and Bioinductivity of Bone Allografts, Annual Meeting of the Orthopaedic Research Society, Chicago, IL March 2006.

56. Wasserman N, Yerramshetty Y, Akkus O, Compositional etiology of microcracks in human cortical bone, Annual Meeting of the Orthopaedic Research Society, Washington D.C. February 2005.

57. Ramasamy JG, Akkus O, Mouse femur adapts to mechanical loading by organizing its lamellar orientation, Annual Meeting of the Orthopaedic Research Society, Washington D.C. February 2005.

58. Yerramshetty JS, Akkus O; Age-related changes in the compositional heterogeneity of human cortical bone, Annual Meeting of the Orthopaedic Research Society, Washington D.C. February 2005.

59. Wasserman N, Korlepara V, Akkus O, Acoustic emission technique can predict the fatigue failure of cortical bone, Annual Meeting of the Orthopaedic Research Society, Washington D.C. February 2005.

60. Wasserman N., Yerramshetty J., Akkus O., Compositional etiology of in vivo microcracks in human cortical bone, Annual Meeting of the Biomedical Engineering Society, Philadelphia PA, October 2004.

61. Goundiah-Ramasamy J., Akkus O., Mouse femoral shaft adapts to tension anteriorly and compression posteriorly, Annual Meeting of the Biomedical Engineering Society, Philadelphia PA, October 2004.

62. Das P., Azad A-M., Akkus O., Maximization of mineral content in polymeric gels,  Annual Meeting of the Biomedical Engineering Society, October 2004.

63. Yerramshetty J., Akkus O., Age-related changes in the compositional and physicochemical heterogeneity of cortical bone, Annual Meeting of the Biomedical Engineering Society, October 2004.

64. Akkus O and Wasserman N, Microcracks colocalize within highly mineralized and more crystalline locations of bone tissue, Annual Meeting of the European Society of Biomechanics, s'Hertogenbosch, Netherlands, July 2004.

65. Belaney RM and Akkus O, The biomechanical impairment of bone allografts during gamma radiation sterilization can be reduced by free radical scavengers, 50^th Annual Meeting of the Orthopaedic Research Society, San Francisco, 2004.

66. Akkus O., Adar F., Schaffler M.B., Compositional changes impair the elastic properties of aging rat cortical bone, 49th Annual Meeting of the Orthopaedic Research Society, New Orleans, 2003.

67. Akkus O., Akkus A., Adar F., Schaffler M.B., Long term compositional changes during aging of unremodeled compartments of human compact bone, 49th Annual Meeting of the Orthopaedic Research Society, New Orleans, 2003.

68. Akkus O., Adar F., Schaffler M.B., Mineral crystals carry greater loads under compression than in tension, 49th Annual Meeting of the Orthopaedic Research Society, New Orleans, 2003.

69. Akkus O., Adar F., Schaffler M.B., Prestresses on mineral crystals of bone are relieved upon fracture, 49th Annual Meeting of the Orthopaedic Research Society, New Orleans, 2003.

70. Clement M.O., Hernandez C.J., Akkus, O., Tommasini S.M., Bloomfield S.M., Allen M.R., Schaffler M.B., Can adult long bones recover their mechanical integrity after long-term disuse osteoporosis?,  49th Annual Meeting of the Orthopaedic Research Society, New Orleans, 2003.

71. Akkus O., Adar F., Schaffler M.B., Strain and Fracture Induced Changes in Bone Mineral Crystals, ASME IMECE 2002, New Orleans LA, November 2002.

72. Akkus O., Adar F., Schaffler M.B., Increased Collagen Mineralization Affects the Yield Stress but not the Yield Strain in Cortical Bone of Rats: Implications for Age-Related Tissue Embrittlement, ASME IMECE 2002, New Orleans LA, November 2002.

73. Jepsen K.J., Akkus O., Warman M., Nadeau J.H., Cluster Analysis Predicts Whole Bone Function in Inbred Mouse Strains Using Non-invasive Measures of Bone Geometry and Composition, ASBMR Meeting, Journal of Bone and Mineral Research, 16: S471-S471, Suppl. 1 SEP 2001.

74. Davy, D.T., Jepsen, K.J., Bensusan, J.B., Wilson, J., and Akkus, O., Damage Effects in Cortical Bone are Similar in Tension, Compression and Torsion, Biomedical Engineering Society Meeting, Durham NC, October 2001.

75. Akkus, O., David F. Knott, Davy, D.T., and Rimnac, C.M., Linear Microcracks may Contribute Little to Degradation of Youngs Modulus in Cortical Bone Tissue, p79, ASME Summer Bioengineering Conference, Snowbird UT, June 2001.

76. Akkus, O., Nasser, P.R., Kauffman, J.J., and Jepsen, K.J., Simulation of Ultrasonic Wave Propagation in Damaged Cortical Bone, p297, ASME Summer Bioengineering Conference, Snowbird UT, June 2001.

77. Akkus, O., Breedlove A.D., and Rimnac, C.M., Fracture Toughness of Gamma Radiation Sterilized Cortical Bone Allografts. 46th Annual Meeting of the Orthopaedic Research Society, Orlando, 2000.

78. Bensusan, J.B., Akkus, O, Wilson, J, Jepsen, K.J., Davy, D.T., Effect of Loading mode on Predictors of Failure for Human Cortical Bone. 46th Annual Meeting of the Orthopaedic Research Society, Orlando, 2000.

79. Akkus, O., Davy, D.T., and Rimnac, C.M., Microcracks to Macrocracks: Damage Coalescence Mechanisms in Human Cortical Bone. 23rd Annual Meeting of the American Society of Biomechanics.

80. Akkus, O., and Rimnac, C.M., Classification of Microdamage in Human Cortical bone via Acoustic Emission, 17th ISB Congress, Calgary, August 8-13 1999.

81. Akkus, O., Jepsen, K.J., Bensusan, J.B., and Davy, D.T., Tensile Modulus Degradation for Diagnosis of Compressive Creep Damage, 17th ISB Congress, Calgary, August 8-13 1999.

82. Birlik G., Korkusuz F., Akkus O., Akkas N., The Biomechanical Evaluation of Transpedicular Spinal Implants.  Stability in Burst Fractures, 8th International Conference on Biomedical Engineering, Singapore, December 7-10, 1994, pp. 146-148.

83. Akkus, O., Omeroglu, H., Ates, Y., Korkusuz, F., and Akkas, N., Biomechanical Analysis of the Effects of Single High Dose Vitamin D3 on Fracture Healing in a Healthy Rabbit Model, Third Biennial Joint Conference on Engineering Systems Design and Analysis, ASME International Petroleum Division, July 1-4 1996, Montpellier, France.

84. Akkus, O., Korkusuz, F., Korkusuz, P., Akin, S., and Akkas, N., Biomechanical Evaluation of Fracture Healing in Long Bones: A Comparative Study with Bone Density Measurements, QCT and Histology, Third Biennial Joint Conference on Engineering Systems Design and Analysis, ASME International Petroleum Division, July 1-4 1996, Montpellier, France.

85. Komurcu, M., Akkus, O., Basbozkurt, M., Gur, E., and Akkas, N., Biomechanical Determination of Restrictive Adhesion in Surgically Traumatized Flexor Tendons, Third Biennial Joint Conference on Engineering Systems Design and Analysis, ASME International Petroleum Division, July 1-4 1996, Montpellier, France.

86. Gursel, I., Arica, M., Hasirci, V., Balcik, C., Akkus, O., and Akkas, N., Interpenetrating Networks of Polyhydroxybutyrate-Cohydroxyvalerate Polyhydroxyethyl Methacrylate: Mechanical Properties, Third Biennial Joint Conference on Engineering Systems Design and Analysis, ASME International Petroleum Division, July 1-4 1996, Montpellier, France.

87. Pamas, L., Kus, V., Akkus, O., and Akkas, N., Torsion Investigation of Filament-Wound Pipes, Ninth International Conference on Mechanics of Composite Materials, October 17-20 1995, Riga, Latvia.

88. Birlik G., Korkusuz F., Akkus O., Akkas, N.,: Assessment of Spinal Implants Under Cyclic Loading, 3rd International Congress on Spine Surgery, Antalya, Turkey, October 2-6, 1994.

89. Akkus O., Korkusuz F., Akkas, N.,: Monitoring Fracture Healing Using Vibration Analysis, SICOT Regional Congress'95 Abstract Book (TURKEY), 29 September-4 October, 1995, pp.281.