Systems Modeling & Complex Systems Biology

Close up view of an engineering working on a graph on a computer screen

At Case Western Reserve, we’re conducting interdisciplinary research that combines experimental, computational or mathematical disciplines so faculty and students can better understand complex biological systems. We’re discovering networks involved in human disease and developing new technologies for different treatments.

Researchers are observing the essential patterns of life through the evolution of organisms and species to form complex system models. For example, our researchers have found that a genetic process among many species of rodents could have significant implications about sex determination. 

We’re analyzing the Sry gene, or mammalian gene, which is the sex-determining region Y protein. This protein is involved in male sexual development, which is usually determined by the chromosomes an individual has.

By continuing to explore the effects of this gene, researchers can expand their understanding of human evolution and genetics.

Faculty who conduct research in Systems Modeling & Complex Systems Biology

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Evren Gurkan Cavusoglu

Assistant Professor, Department of Electrical, Computer and Systems Engineering

Develops dynamical models of biological systems to help improve treatment of complex diseases

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Behnam Malakooti

Fellow of IEEE, Society of Manufacturing Engineers, & Ins. of Industrial & Systems Engineers
Professor, Department of Electrical, Computer and Systems Engineering

Designs & develops models for industrial, operations, production/manufacturing systems, asymmetric risk analysis & predictions, decision making/behaviour types, artificial neural networks, interactive models, and multiple objective optimization.

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Sree Sreenath

Professor, Department of Electrical, Computer and Systems Engineering

I will continue to work in the Complex Systems Biology area with a thrust on Mammalian Cancer Biology.