Horst von Recum

Professor, Biomedical Engineering Director, Pluripotent Stem Cell Facility at the National Center for Regenerative Medicine Director, Image Guided Therapeutics subsection of the Cancer Imaging Program at the Case Comprehensive Cancer Center
Office: 220 Wickenden Phone Number: (216) 368-5513 Email: horst.vonrecum@case.edu

Education

Post Graduate, Bioengineering, University of Washington, 2004
Post Graduate, Chemical Engineering, Massachusetts Institute of Technology, 2001
Ph.D., Bioengineering, University of Utah, 1998
Other, Chemical Engineering, Rice University, 1993
B.A., Biochemistry, Rice University, 1992
B.A., Chemical Engineering, Rice University, 1992

Research Interests

Drug Delivery, Stem Cells, Tissue Engineering

Teaching Interests

Drug Delivery

Professional Leadership and Service

Jan. 1, 1995 - PRESENT, Biomedical Engineering Society

Publications

Rohner, N., Purdue, L., & Von Recum, H. (2020). Affinity-based polymers provide long-term immunotherapeutic drug delivery across particle size ranges optimal for macrophage targeting. Journal of Pharmaceutical Sciences.
Dogan, A., & Von Recum, H. (2020). Engineering Selective Molecular Tethers to Enhance Suboptimal Drug Properties. Acta Biomaterialia, 115 , 383-392.
Cyphert, E., Learn, G., Marques, D., Lu, C., & Von Recum, H. (2020). Antibiotic Refilling, Antimicrobial Activity, and Mechanical Strength of PMMA Bone Cement Composites Critically Depend on the Processing Technique. ACS Biomaterials Science & Engineering, 6 (7), 4024-4035.
Rohner, N., Schomisch, S., Chak, A., Marks, J., & Von Recum, H. (2020). Mo1288 ENDOSCOPIC LOCAL INJECTION OF SIROLIMUS TO PREVENT ESOPHAGEAL STRICTURE POST-ENDOSCOPIC SUBMUCOSAL DISSECTION. Gastrointestinal Endoscopy, 91 (6).
Cyphert, E., Bilici, M., Von Recum, H., & Święszkowski, W. (2020). Repurposing biodegradable tissue engineering scaffolds for localized chemotherapeutic delivery.. Journal of biomedical materials research. Part A, 108 (5), 1144-1158.
Zuckerman, S., Rivera-Delgado, E., Haley, R., Korley, J., & Von Recum, H. (2020). Elucidating the Structure-Function Relationship of Solvent and Cross-Linker on Affinity-Based Release from Cyclodextrin Hydrogels.. Gels (Basel, Switzerland), 6 (1).
Rohner, N., Nguyen, T., & Von Recum, H. (2020). Affinity Effects on the Release of Non-Conventional Antifibrotics from Polymer Depots.. Pharmaceutics, 12 (3).
Cyphert, E., Lu, C., Marques, D., Learn, G., & Von Recum, H. (2020). Combination Antibiotic Delivery in PMMA Provides Sustained Broad-Spectrum Antimicrobial Activity and Allows for Postimplantation Refilling.. Biomacromolecules, 21 (2), 854-866.
Iyer, R., Gorelick, N., Carroll, K., Blitz, A., Beck, S., Garrett, C., Monroe, A., Tyler, B., Zuckerman, S., Capadona, J. R., Von Recum, H. R., & Luciano, M. R. (2019). Evaluation of an in vivo model for ventricular shunt infection: a pilot study using a novel antimicrobial-loaded polymer. Journal of Neurosurgery Pediatrics, 131 (2), 587-595.
Iyer, R., Gorelick, N., Carroll, K., Blitz, A., Beck, S., Garrett, C., Monroe, A., Tyler, B., Zuckerman, S., Capadona, J. R., Von Recum, H. R., & Luciano, M. R. (2019). Evaluation of an in vivo model for ventricular shunt infection: a pilot study using a novel antimicrobial-loaded polymer. Journal of Neurosurgery Pediatrics, 131 (2), 587-595.
Haley, R., & Von Recum, H. (2019). Localized and targeted delivery of NSAIDs for treatment of inflammation: A review. Experimental Biology and Medicine, 244 (6), 433-444.
Rohner, N., Schomisch, S., Marks, J., & Von Recum, H. (2019). Cyclodextrin Polymer Preserves Sirolimus Activity and Local Persistence for Antifibrotic Delivery over the Time Course of Wound Healing. Molecular Pharmaceutics, 16 (4), 1766-1774.
Von Recum, H. (2019). Microbiome: Our opponents or allies in healthcare and medicine. Experimental Biology and Medicine, 244 (6), 405-407.
Haley, R., Zuckerman, S., Gormley, C., Korley, J., & Von Recum, H. (2019). Local delivery polymer provides sustained antifungal activity of amphotericin B with reduced cytotoxicity. Experimental Biology and Medicine, 244 (6), 526-533.
Rohner, N., Schomisch, S., Marks, J., & Von Recum, H. (2019). Cyclodextrin Polymer Preserves Sirolimus Activity and Local Persistence for Antifibrotic Delivery over the Time Course of Wound Healing.. Molecular pharmaceutics, 16 (4), 1766-1774.
Juric, D., Rohner, N., & Von Recum, H. (2019). Molecular Imprinting of Cyclodextrin Supramolecular Hydrogels Improves Drug Loading and Delivery. Macromolecular Bioscience, 19 (1).
Rohner, N., Dogan, A., Robida, O., & Von Recum, H. (2019). Serum biomolecules unable to compete with drug refilling into cyclodextrin polymers regardless of the form. Journal of Materials Chemistry B, 7 (35), 5320-5327.
Cyphert, E., Learn, G., Hurley, S., Lu, C., & Von Recum, H. (2018). An Additive to PMMA Bone Cement Enables Postimplantation Drug Refilling, Broadens Range of Compatible Antibiotics, and Prolongs Antimicrobial Therapy. Advanced Healthcare Materials.
Iyer, R., Gorelick, N., Carroll, K., Blitz, A., Beck, S., Garrett, C., Monroe, A., Tyler, B., Zuckerman, S., Capadona, J. R., Von Recum, H. R., & Luciano, M. R. (2018). Evaluation of an in vivo model for ventricular shunt infection: a pilot study using a novel antimicrobial-loaded polymer. Journal of Neurosurgery Pediatrics.
Rivera-Delgado, E., Djuhadi, A., Danda, C., Kenyon, J., Maia, J. M., Caplan, A. M., & Von Recum, H. M. (2018). Injectable liquid polymers extend the delivery of corticosteroids for the treatment of osteoarthritis. Journal of Controlled Release, 284 , 112-121.
Haley, R., & Von Recum, H. (2018). Localized and targeted delivery of NSAIDs for treatment of inflammation: A review. Experimental Biology and Medicine.
Iyer, R., Gorelick, N., Carroll, K., Blitz, A., Beck, S., Garrett, C., Monroe, A., Tyler, B., Zuckerman, S., Capadona, J. R., Von Recum, H. R., & Luciano, M. R. (2018). Evaluation of an in vivo model for ventricular shunt infection: a pilot study using a novel antimicrobial-loaded polymer. Journal of Neurosurgery Pediatrics.
Iyer, R., Gorelick, N., Carroll, K., Blitz, A., Beck, S., Garrett, C., Monroe, A., Tyler, B., Zuckerman, S., Capadona, J. R., Von Recum, H. R., & Luciano, M. R. (2018). Evaluation of an in vivo model for ventricular shunt infection: a pilot study using a novel antimicrobial-loaded polymer. Journal of Neurosurgery Pediatrics.
Levack, A., Cyphert, E., Bostrom, M., Hernandez, C., Von Recum, H., & Carli, A. (2018). Current Options and Emerging Biomaterials for Periprosthetic Joint Infection. Current Rheumatology Reports, 20 (6).
Cyphert, E., Von Recum, H., Yamato, M., & Nakayama, M. (2018). Surface sulfonamide modification of poly( N -isopropylacrylamide)-based block copolymer micelles to alter pH and temperature responsive properties for controlled intracellular uptake: SURFACE SULFONAMIDE MODIFICATION OF POLY(IPAAM) MICELLE. Journal of Biomedical Materials Research - Part A.
Cyphert, E., Zuckerman, S., Von Recum, H., & Korley, J. (2017). Affinity interactions drive post-implantation drug filling, even in the presence of bacterial biofilm. Acta Biomaterialia.
Cyphert, E., Wallat, J., Pokorski, J. K., & Von Recum, H. K. (2017). Erythromycin Modification That Improves Its Acidic Stability while Optimizing It for Local Drug Delivery. Antibiotics, 6 (2).
Thatiparti, T., Juric, D., & Von Recum, H. (2017). Pseudopolyrotaxane Formation in the Synthesis of Cyclodextrin Polymers: Effects on Drug Delivery, Mechanics, and Cell Compatibility. Bioconjugate Chemistry.
Cyphert, E., Fu, A., & Von Recum, H. (2017). Chemotherapeutic delivery using pH-responsive, affinity-based release. Experimental Biology and Medicine.
Blatnik, J., Thatiparti, T., Krpata, D., Zuckerman, S., Rosen, M., & Von Recum, H. (2017). Infection prevention using affinity polymer-coated, synthetic meshes in a pig hernia model. Journal of Surgical Research, 219 , 5-10.
Rivera-Delgado, E., & Von Recum, H. (2017). Using Affinity To Provide Long-Term Delivery of Antiangiogenic Drugs in Cancer Therapy. Molecular Pharmaceutics.
Cyphert, E., & Von Recum, H. (2017). Emerging technologies for long-term antimicrobial device coatings: advantages and limitations. Experimental Biology and Medicine.
Rivera-Delgado, E., Nam, J., & Von Recum, H. (2017). Localized Affinity-Based Delivery of Prinomastat for Cancer Treatment. ACS Biomaterials Science & Engineering.
Kovach, K., Kumsa, D., Srivastava, V., Hudak, E., Untereker, D., Kelley, S., Von Recum, H., & Capadona, J. R. (2016). High-throughput in vitro assay to evaluate the cytotoxicity of liberated platinum compounds for stimulating neural electrodes. Journal of Neuroscience Methods [01650270], 273 , 9-Jan.
Rivera-Delgado, E., Sadeghi, Z., Wang, N., Kenyon, J., Satyanarayan, S., Kavran, M., Flask, C., Hijaz, A., & Von Recum, H. (2016). Local release from affinity-based polymers increases urethral concentration of the stem cell chemokine CCL7 in rats. Biomedical Materials [17486041], 11 (2).
Grafmiller, K., Zuckerman, S., Petro, C., Liu, L., Von Recum, H., Rosen, M., & Korley, J. (2016). Antibiotic-releasing microspheres prevent mesh infection in vivo. Journal of Surgical Research [00224804], 206 (1), 41-47.
Rivera-Delgado, E., Ward, E., & Von Recum, H. (2016). Providing sustained transgene induction through affinity-based drug delivery: SUSTAINED TRANSGENE INDUCTION. Journal of Biomedical Materials Research - Part A [15493296], 104 (5), 1135-1142.
Von Recum, H. (2016). From Biocompatibility to Immune Engineering. Experimental Biology and Medicine [15353702], 241 (9), 889-890.
Jones, D., Von Recum, H., Sen Gupta, A., & Kottke-Marchant, K. (2015). Photoinitiator-free synthesis of endothelial cell-adhesive and enzymatically degradable hydrogels. ACTA BIOMATERIALIA, 13 , 52-60.
Buerkle, L., Von Recum, H., & Rowan, S. J. (2012). Toward potential supramolecular tissue engineering scaffolds based onguanosine derivatives. CHEMICAL SCIENCE, 3 (2), 564-572.
Fu, X., Thatiparti, T., Saidel, G. M., & Von Recum, H. M. (2011). Experimental studies and modeling of drug release from a tunable affinity-based drug delivery platform.. Annals of biomedical engineering, 39 (9), 2466-75.
Thatiparti, T., Shoffstall, A., & Von Recum, H. (2010). Cyclodextrin-based device coatings for affinity-based release of antibiotics.. Biomaterials, 31 (8), 2335-47.
Alsberg, E., Von Recum, H., & Mahoney, M. (2006). Environmental cues to guide stem cell fate decision for tissue engineering applications. Expert opinion on biological therapy, 6 (9), 847–866.