Gerald Saidel

Professor, Biomedical Engineering
Develops computational models of transport and metabolic processes with applications in drug delivery and tissue engineering
Office: 410 Wickenden Phone Number: (216) 368-4066 Email: gerald.saidel@case.edu

Education

Ph.D., Chemical Engineering, Johns Hopkins University, 1965
Other, Chemical Engineering, Rensselaer Polytechnic Institute , 1960

Awards and Recognitions

2006, Special Recognition Award, Council of Chairs of Bioengineering and Biomedical Engineering
2005, Inaugural Class Fellow, Biomedical Engineering Society
2002, Distinguished Service Award, Biomedical Engineering Society
1994, Meritorious Service Award, Case Alumni Association
1993, Centennial Certificate, American Society of Engineering Education

Research Interests

Mass and heat transport in cells, tissues and organs; mathematical modeling and simulation of dynamic and spatially distributed systems; nonlinear parameter estimation and optimal design of experiments

Teaching Interests

transport processes,
modeling and analysis of dynamic systems,
optimal parameter estimation
biomedical applications of methodology

Patents Received

2010, "System and methods for image-guided thermal treatment of tissue" US7699838B2, David Wilson, Gerald Saidel, & Michael Breen.

Publications

Chariou, P., Dogan, A., Welsh, A., Saidel, G. M., Baskaran, H. M., & Steinmetz, N. M. (2019). Soil mobility of synthetic and virus-based model nanopesticides. Nature Nanotechnology, 14 (7), 712-718.
Chariou, P., Dogan, A., Welsh, A., Saidel, G. M., Baskaran, H. M., & Steinmetz, N. M. (2019). Soil mobility of synthetic and virus-based model nanopesticides. Nature Nanotechnology, 14 (7), 712-718.
Sarkar, J., Potdar, A., & Saidel, G. M. (2018). Whole-body iron transport and metabolism: Mechanistic, multi-scale model to improve treatment of anemia in chronic kidney disease. PLoS Computational Biology, 14 (4).
Fu, X., Solorio, L., Alsberg, E., & Saidel, G. M. (2017). Mathematical modelling of glycosaminoglycan production by stem cell aggregates incorporated with growth factor-releasing polymer microspheres.. Journal of tissue engineering and regenerative medicine, 11 (2), 481-488.
Fu, A., Solorio, L., Alsberg, E., & Saidel, G. M. (2017). Mathematical modelling of glycosaminoglycan production by stem cell aggregates incorporated with growth factor-releasing polymer microspheres. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 11 (2), 481-488.
Saidel, G. M. (2016). Diffusion and uptake of tobacco mosaic virus as therapeutic carrier in tumor tissue: effect of nanoparticle aspect ratio. J Phys Chem B. 2016 Jul 7;120(26):6120-9.
Chariou, P., Lee, K., Pokorski, J. K., Saidel, G. M., & Steinmetz, N. M. (2016). Diffusion and Uptake of Tobacco Mosaic Virus as Therapeutic Carrier in Tumor Tissue: Effect of Nanoparticle Aspect Ratio. Journal of Physical Chemistry B [15206106], 120 (26), 6120-6129.
Fu, A., Solorio, L., Alsberg, E., & Saidel, G. M. (2014). Mathematical modelling of glycosaminoglycan production by stem cell aggregates incorporated with growth factor-releasing polymer microspheres. Journal of tissue engineering and regenerative medicine.
Heylman, C., Santoso, S., Krebs, M., Saidel, G. M., Alsberg, E. M., & Muschler, G. M. (2014). Modeling and experimental methods to predict oxygen distribution in bone defects following cell transplantation. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 52 (4), 321-330.
Heylman, C., Santoso, S., Krebs, M., Saidel, G. M., Alsberg, E. M., & Muschler, G. M. (2014). Modeling and experimental methods to predict oxygen distribution in bone defects following cell transplantation. Medical & biological engineering & computing, 52 (4), 321–330.
Spires, J., Gladden, L., Grassi, B., Goodwin, M., Saidel, G. M., & Lai, N. M. (2013). Distinguishing the effects of convective and diffusive O₂ delivery on VO₂ on-kinetics in skeletal muscle contracting at moderate intensity.. American journal of physiology. Regulatory, integrative and comparative physiology, 305 (5), R512-21.
Spires, J., Gladden, L., Grassi, B., Saidel, G. M., & Lai, N. M. (2012). Model analysis of the relationship between intracellular PO2 and energy demand in skeletal muscle.. American journal of physiology. Regulatory, integrative and comparative physiology, 303 (11), R1110-26.
Yao, P., Potdar, A., Alsharif, S., Ray, S., Mukhopadhyay, R., Willard, B., Xu, W., Ryan, J., Saidel, G. M., & Fox, P. M. (2012). Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression.. Cell, 149 (1), 88-100.
Li , Y., Lai, N., Kirwan, J., & Saidel, G. M. (2012). Computational Model of Cellular Metabolic Dynamics in Skeletal Muscle Fibers during Moderate Intensity Exercise.. Cellular and molecular bioengineering, 5 (1), 92-112.
Fu, X., Thatiparti, T., Saidel, G. M., & Von Recum, H. M. (2011). Experimental studies and modeling of drug release from a tunable affinity-based drug delivery platform.. Annals of biomedical engineering, 39 (9), 2466-75.
Kim, J., Saidel, G. M., & Kalhan, S. M. (2011). Regulation of Adipose Tissue Metabolism in Humans: Analysis of Responses to the Hyperinsulinemic-Euglycemic Clamp Experiment.. Cellular and molecular bioengineering, 4 (2), 281-301.
Plusquellic, J., Banerjee, S., Saidel, G. M., & Yu, X. M. (2011). Regulation of cytosolic and mitochondrial oxidation via malate-aspartate shuttle: an observation using dynamic ¹³C NMR spectroscopy.. Advances in experimental medicine and biology, 701 , 185-92.
Plusquellic, J., Banerjee, S., Saidel, G. M., & Yu, X. M. (2011). Regulation of cytosolic and mitochondrial oxidation via malate-aspartate shuttle: an observation using dynamic ¹³C NMR spectroscopy.. Advances in experimental medicine and biology, 701 , 185-92.
Spires, J., Lai, N., Zhou, Z., & Saidel, G. M. (2011). Hemoglobin and myoglobin contributions to skeletal muscle oxygenation in response to exercise.. Advances in experimental medicine and biology, 701 , 347-52.
Li , Y., Solomon, T., Haus, J., Saidel, G. M., Cabrera, M. M., & Kirwan, J. M. (2010). Computational model of cellular metabolic dynamics: effect of insulin on glucose disposal in human skeletal muscle.. American journal of physiology. Endocrinology and metabolism, 298 (6), E1198-209.
Cheng, X., & Saidel, G. M. (2010). Modeling of laser coagulation of tissue with MRI temperature monitoring.. Journal of biomechanical engineering, 132 (6), 064503.
Lai, N., Zhou, Z., Saidel, G. M., Wolfe, M. M., McCully, K. M., Gladden, L. M., & Cabrera, M. M. (2009). Modeling oxygenation in venous blood and skeletal muscle in response to exercise using near-infrared spectroscopy.. Journal of applied physiology (Bethesda, Md. : 1985), 106 (6), 1858-74.
Zhou, Z., Lai, N., Saidel, G. M., & Cabrera, M. M. (2009). Multiscale modeling of respiration.. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society, 28 (3), 34-40.
Li , Y., Dash, R., Kim, J., Saidel, G. M., & Cabrera, M. M. (2009). Role of NADH/NAD+ transport activity and glycogen store on skeletal muscle energy metabolism during exercise: in silico studies.. American journal of physiology. Cell physiology, 296 (1), C25-46.
Cheng, X., & Saidel, G. M. (2009). Mathematical modeling of thermal ablation in tissue surrounding a large vessel.. Journal of biomechanical engineering, 131 (1), 011001.
Lai, N., Saidel, G. M., Iorio, M. M., & Cabrera, M. M. (2009). Non-invasive estimation of metabolic flux and blood flow in working muscle: effect of blood-tissue distribution.. Advances in experimental medicine and biology, 645 , 155-60.
Lee, K., Saidel, G. M., & Penn, M. M. (2008). Permeability change of arterial endothelium is an age-dependent function of lesion size in apolipoprotein E-null mice.. American journal of physiology. Heart and circulatory physiology, 295 (6), H2273-9.
Weinberg, B., Patel, A., Wu, H., Blanco, E., Barnett, C., Exner, A., Saidel, G. M., & Gao, J. M. (2008). Model simulation and experimental validation of intratumoral chemotherapy using multiple polymer implants.. Medical & biological engineering & computing, 46 (10), 1039-49.
Plusquellic, J., Zhou, L., Stanley, W., Cabrera, M., Saidel, G. M., & Yu, X. M. (2008). Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia.. Journal of theoretical biology, 254 (2), 466-75.
Plusquellic, J., Zhou, L., Stanley, W., Cabrera, M., Saidel, G. M., & Yu, X. M. (2008). Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia.. Journal of theoretical biology, 254 (2), 466-75.
Dash, R., Li , Y., Kim, J., Beard, D., Saidel, G. M., & Cabrera, M. M. (2008). Metabolic dynamics in skeletal muscle during acute reduction in blood flow and oxygen supply to mitochondria: in-silico studies using a multi-scale, top-down integrated model.. PloS one, 3 (9), e3168.
Exner, A., & Saidel, G. M. (2008). Drug-eluting polymer implants in cancer therapy.. Expert opinion on drug delivery, 5 (7), 775-88.
Kim, J., Saidel, G. M., & Kalhan, S. M. (2008). A computational model of adipose tissue metabolism: evidence for intracellular compartmentation and differential activation of lipases.. Journal of theoretical biology, 251 (3), 523-40.
Dash, R., Li , Y., Kim, J., Saidel, G. M., & Cabrera, M. M. (2008). Modeling cellular metabolism and energetics in skeletal muscle: large-scale parameter estimation and sensitivity analysis.. IEEE transactions on bio-medical engineering, 55 (4), 1298-318.
Yaniv, Y., Stanley, W., Saidel, G. M., Cabrera, M. M., & Landesberg, A. M. (2008). The role of Ca2+ in coupling cardiac metabolism with regulation of contraction: in silico modeling.. Annals of the New York Academy of Sciences, 1123 , 69-78.
Zhou, Z., Lai, N., Saidel, G. M., & Cabrera, M. M. (2008). Multi-scale model of O2 transport and metabolism: response to exercise.. Annals of the New York Academy of Sciences, 1123 , 178-86.
Cheng, X., Barkauskas, K., Weinberg, B., Duerk, J., Abdul-Karim, F., Paul, S., & Saidel, G. M. (2008). Dynamics of MRI-Guided thermal ablation of VX2 tumor in paraspinal muscle of rabbits.. IEEE transactions on bio-medical engineering, 55 (3), 1004-14.
Zhou, Z., Saidel, G. M., & LaManna, J. M. (2008). Cerebral blood flow adaptation to chronic hypoxia.. Advances in experimental medicine and biology, 614 , 371-7.
Lai, N., Syed, T., Saidel, G. M., & Cabrera, M. M. (2008). Muscle oxygen uptake differs from consumption dynamics during transients in exercise.. Advances in experimental medicine and biology, 614 , 325-32.
Weinberg, B., Patel, A., Exner, A., Saidel, G. M., & Gao, J. M. (2007). Modeling doxorubicin transport to improve intratumoral drug delivery to RF ablated tumors.. Journal of controlled release : official journal of the Controlled Release Society, 124 (1-2), 11-9.
Lai, N., Saidel, G. M., Grassi, B. M., Gladden, L. M., & Cabrera, M. M. (2007). Model of oxygen transport and metabolism predicts effect of hyperoxia on canine muscle oxygen uptake dynamics.. Journal of applied physiology (Bethesda, Md. : 1985), 103 (4), 1366-78.
Breen, M., Butts, K., Slipchenko, M., Saidel, G. M., & Wilson, D. L. (2007). MRI-guided thermal ablation therapy: model and parameter estimates to predict cell death from MR thermometry images.. Annals of biomedical engineering, 35 (8), 1391-403.
Cheng, X., Barkauskas, K., Nour, S., Duerk, J., Abdul-Karim, F., & Saidel, G. M. (2007). Magnetic resonance imaging and model prediction for thermal ablation of tissue.. Journal of magnetic resonance imaging : JMRI, 26 (1), 123-32.
Zhou, Z., Saidel, G. M., & Cabrera, M. M. (2007). Multi-organ system model of O2 and CO2 transport during isocapnic and poikilocapnic hypoxia.. Respiratory physiology & neurobiology, 156 (3), 320-30.
Lai, N., Camesasca, M., Saidel, G. M., Dash, R. M., & Cabrera, M. M. (2007). Linking pulmonary oxygen uptake, muscle oxygen utilization and cellular metabolism during exercise.. Annals of biomedical engineering, 35 (6), 956-69.
Wang, F., Saidel, G. M., & Gao, J. M. (2007). A mechanistic model of controlled drug release from polymer millirods: effects of excipients and complex binding.. Journal of controlled release : official journal of the Controlled Release Society, 119 (1), 111-20.
Salinas, C., Muzic, Jr, R., & Saidel, G. M. (2007). Validity of model approximations for receptor-ligand kinetics in nuclear medicine.. Medical physics, 34 (5), 1693-703.
Salinas, C., Muzic, Jr, R., Ernsberger, P., & Saidel, G. M. (2007). Robust experiment design for estimating myocardial beta adrenergic receptor concentration using PET.. Medical physics, 34 (1), 151-65.
Kim, J., Saidel, G. M., & Cabrera, M. M. (2007). Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control.. Annals of biomedical engineering, 35 (1), 69-90.
Landesberg, A., Shenhav, A., Shofty, R., Konyukhov, E., Levy, C., Lichtenstein, O., Beyar, R., Ter Keurs, H., Landesberg, G., Cabrera, M., Stanley, W., & Saidel, G. M. (2006). Effects of synchronized cardiac assist device on cardiac energetics.. Annals of the New York Academy of Sciences, 1080 , 466-78.
Lai, N., Dash, R., Nasca, M., Saidel, G. M., & Cabrera, M. M. (2006). Relating pulmonary oxygen uptake to muscle oxygen consumption at exercise onset: in vivo and in silico studies.. European journal of applied physiology, 97 (4), 380-94.
Kim, J., Saidel, G. M., Kirwan, J. M., & Cabrera, M. M. (2006). Computational model of glucose homeostasis during exercise.. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 1 , 311-4.
Zhou, L., Stanley, W., Saidel, G. M., Yu, X. M., & Cabrera, M. M. (2005). Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies.. The Journal of physiology, 569 (Pt 3), 925-37.
Lee, K., Saidel, G. M., & Penn, M. M. (2005). Macromolecular transport in the arterial wall: alternative models for estimating barriers.. Annals of biomedical engineering, 33 (11), 1491-503.
Lee, K., Forudi, F., Saidel, G. M., & Penn, M. M. (2005). Alterations in internal elastic lamina permeability as a function of age and anatomical site precede lesion development in apolipoprotein E-null mice.. Circulation research, 97 (5), 450-6.
Cabrera, M., Zhou, L., Stanley, W., & Saidel, G. M. (2005). Regulation of cardiac energetics: role of redox state and cellular compartmentation during ischemia.. Annals of the New York Academy of Sciences, 1047 , 259-70.
Zhou, L., Salem, J., Saidel, G. M., Stanley, W. M., & Cabrera, M. M. (2005). Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia.. American journal of physiology. Heart and circulatory physiology, 288 (5), H2400-11.
Qian, F., Stowe, N., Saidel, G. M., & Gao, J. M. (2004). Comparison of doxorubicin concentration profiles in radiofrequency-ablated rat livers from sustained- and dual-release PLGA millirods.. Pharmaceutical research, 21 (3), 394-9.
Breen, M., Butts, K., Chen, L., Saidel, G. M., & Wilson, D. L. (2004). MRI-guided laser thermal ablation: Model and parameter estimates relating MR thermometry images to cell death. 2004 2nd Ieee International Symposium on Biomedical Imaging: Macro to Nano, Vols 1 and 2.
Breen, M., Butts, K., Chen, L., Saidel, G. M., & Wilson, D. L. (2004). MRI-guided laser thermal ablation: Model to predict cell death from MR thermometry images for real-time therapy monitoring. Proceedings of the 26th Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Vols 1-7, 26 , 1028-1031.
Liu, X., Saidel, G. M., & Harasaki, H. M. (2003). Model analysis of tissue responses to transient and chronic heating.. Annals of biomedical engineering, 31 (8), 1007-14.
Qian, F., Stowe, N., Liu, X., Saidel, G. M., & Gao, J. M. (2003). Quantification of in vivo doxorubicin transport from PLGA millirods in thermoablated rat livers.. Journal of controlled release : official journal of the Controlled Release Society, 91 (1-2), 157-66.
Knepper, M., Saidel, G. M., Hascall, V. M., & Dwyer, T. M. (2003). Concentration of solutes in the renal inner medulla: interstitial hyaluronan as a mechano-osmotic transducer.. American journal of physiology. Renal physiology, 284 (3), F433-46.
Muzic, Jr, R., & Saidel, G. M. (2003). Distributed versus compartment models for PET receptor studies.. IEEE transactions on medical imaging, 22 (1), 11-21.
Qian, F., Saidel, G. M., Sutton, D. M., Exner, A. M., & Gao, J. M. (2002). Combined modeling and experimental approach for the development of dual-release polymer millirods.. Journal of controlled release : official journal of the Controlled Release Society, 83 (3), 427-35.
Salem, J., Saidel, G. M., Stanley, W. M., & Cabrera, M. M. (2002). Mechanistic model of myocardial energy metabolism under normal and ischemic conditions.. Annals of biomedical engineering, 30 (2), 202-16.
Breen, M., Chen, X., Wilson, D. L., & Saidel, G. M. (2002). Modeling cellular thermal damage from radio-frequency ablation. Second Joint Embs-Bmes Conference 2002, Vols 1-3, Conference Proceedings.
Johnson, S., & Saidel, G. M. (2002). Thermal model for fast simulation during magnetic resonance imaging guidance of radio frequency tumor ablation.. Annals of biomedical engineering, 30 (9), 1152-61.
Kump, K., Saidel, G. M., & Wilson, D. L. (2001). Comparison of algorithms for combining X-ray angiography images.. IEEE transactions on medical imaging, 20 (8), 742-50.
Saidel, G. M., & Liu, X. M. (2001). Model transformations to evaluate transient thermal responses at a tissue surface.. Journal of biomechanical engineering, 123 (4), 370-2.
Saidel, G. M., Davies, C. M., Liu, X. M., & Harasaki, H. M. (2001). Temperature and perfusion responses of muscle and lung tissue during chronic heating in vivo.. Medical & biological engineering & computing, 39 (1), 126-33.
Muzic, Jr, R., Saidel, G. M., Zhu, L. M., Virnelson, R. M., Zheng, R. M., & Berridge, M. M. (2000). Iterative optimal design of PET experiments for estimating beta-adrenergic receptor concentration.. Medical & biological engineering & computing, 38 (6), 593-602.
Cabrera, M., Saidel, G. M., & Kalhan, S. M. (1999). A model analysis of lactate accumulation during muscle ischemia.. Journal of critical care, 14 (4), 151-63.
Cabrera, M., Saidel, G. M., & Kalhan, S. M. (1999). Lactate metabolism during exercise: analysis by an integrative systems model.. The American journal of physiology, 277 (5 Pt 2), R1522-36.
Yi, C., Saidel, G. M., & Gratzl, M. M. (1999). Single cell model for simultaneous drug delivery and efflux.. Annals of biomedical engineering, 27 (2), 208-18.
Yi, C., Saidel, G. M., & Gratzl, M. M. (1999). Single cell model for simultaneous drug delivery and efflux.. Annals of biomedical engineering, 27 (2), 208-18.
Seese, T., Harasaki, H., Saidel, G. M., & Davies, C. M. (1998). Characterization of tissue morphology, angiogenesis, and temperature in the adaptive response of muscle tissue to chronic heating.. Laboratory investigation; a journal of technical methods and pathology, 78 (12), 1553-62.
Bertrand, C., Durand, D. M., Saidel, G. M., Laboisse, C. M., & Hopfer, U. M. (1998). System for dynamic measurements of membrane capacitance in intact epithelial monolayers.. Biophysical journal, 75 (6), 2743-56.
Fernandez, C., Saidel, G. M., Malchesky, P. M., & Zborowski, M. M. (1998). A mechanistic model of plasma filtration.. Medical engineering & physics, 20 (5), 383-92.
Cabrera, M., Saidel, G. M., & Kalhan, S. M. (1998). Role of O2 in regulation of lactate dynamics during hypoxia: mathematical model and analysis.. Annals of biomedical engineering, 26 (1), 1-27.
Cabrera, M., Saidel, G. M., & Kalhan, S. M. (1998). Modeling metabolic dynamics. From cellular processes to organ and whole body responses.. Progress in biophysics and molecular biology, 69 (2-3), 539-57.
Penn, M., Rangaswamy, S., Saidel, G. M., & Chisolm, G. M. (1997). Macromolecular transport in the arterial intima: comparison of chronic and acute injuries.. The American journal of physiology, 272 (4 Pt 2), H1560-70.
Davies, C., Saidel, G. M., & Harasaki, H. M. (1997). Sensitivity analysis of one-dimensional heat transfer in tissue with temperature-dependent perfusion.. Journal of biomechanical engineering, 119 (1), 77-80.
Rangaswamy, S., Penn, M., Saidel, G. M., & Chisolm, G. M. (1997). Exogenous oxidized low-density lipoprotein injures and alters the barrier function of endothelium in rats in vivo.. Circulation research, 80 (1), 37-44.
Talbot, A., Neuman, M., Saidel, G. M., & Jacobsen, E. M. (1996). Dynamic model of oxygen transport for transcutaneous PO2 analysis.. Annals of biomedical engineering, 24 (2), 294-304.
Muzic, Jr, R., Virnelson, R., Saidel, G. M., & Miraldi, F. M. (1996). Optimal experiment design for PET quantification of receptor concentration.. IEEE transactions on medical imaging, 15 (1), 2-12.
Oku, Y., Saidel, G. M., Cherniack, N. M., & Altose, M. M. (1996). Effects of willful ventilatory control on respiratory sensation during hypercapnia.. Respiration; international review of thoracic diseases, 63 (3), 137-43.
Oku, Y., Saidel, G. M., Cherniack, N. M., & Altose, M. M. (1995). Model of respiratory sensation and wilful control of ventilation.. Medical & biological engineering & computing, 33 (3), 252-6.
Weir, R., Saidel, G. M., & Jones, S. M. (1995). Estimation of cerebral blood flow from thermal measurement.. Journal of biomechanical engineering, 117 (1), 74-85.
Weir, R., Saidel, G. M., & Jones, S. M. (1994). Thermal method for continuous measurement of cerebral perfusion.. Medical & biological engineering & computing, 32 (5), 481-8.
Saidel, G. M., & Chang, C. M. (1994). CO2 control of breathing: parameter estimation and stability evaluation.. Medical engineering & physics, 16 (2), 135-42.
Penn, M., Saidel, G. M., & Chisolm, G. M. (1994). Relative significance of endothelium and internal elastic lamina in regulating the entry of macromolecules into arteries in vivo.. Circulation research, 74 (1), 74-82.
Dexter, F., Rudy, Y., & Saidel, G. M. (1994). Mathematical model of acetylcholine kinetics in neuroeffector junctions.. The American journal of physiology, 266 (1 Pt 2), H298-309.
Oku, Y., Saidel, G. M., Altose, M. M., & Cherniack, N. M. (1993). Perceptual contributions to optimization of breathing.. Annals of biomedical engineering, 21 (5), 509-15.
Weir, R., Shearer, K., Saidel, G. M., & Jones, S. M. (1993). Validation of continuous thermal measurement of cerebral blood flow by arterial pressure change.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 13 (4), 693-701.
Ali-Hassan, W., Saidel, G. M., & Durand, D. M. (1992). Estimation of electrotonic parameters of neurons using an inverse Fourier transform technique.. IEEE transactions on bio-medical engineering, 39 (5), 493-501.
Penn, M., Saidel, G. M., & Chisolm, G. M. (1992). Vascular injury by endotoxin: changes in macromolecular transport parameters in rat aortas in vivo.. The American journal of physiology, 262 (5 Pt 2), H1563-71.
Lichtenstein, O., Ben-Haim, S., Saidel, G. M., & Dinnar, U. M. (1992). Role of the diaphragm in chest wall mechanics.. Journal of applied physiology (Bethesda, Md. : 1985), 72 (2), 568-74.
Morrison, R., Saidel, G. M., & Chisolm, 3rd, G. M. (1991). Optimal design of experiments to estimate LDL transport parameters in arterial wall.. The American journal of physiology, 261 (3 Pt 2), H929-49.
Teeter, J., Saidel, G. M., & Fouke, J. M. (1991). Contribution of large airway to the input impedance of the respiratory system.. Journal of applied physiology (Bethesda, Md. : 1985), 70 (2), 650-7.
Oku, Y., Saidel, G. M., Chonan, T. M., Altose, M. M., & Cherniack, N. M. (1991). Sensation and control of breathing: a dynamic model.. Annals of biomedical engineering, 19 (3), 251-72.
Cabrera, M., Saidel, G. M., & Cohen, M. M. (1991). Noninvasive estimation of cardiac output with nonprescribed breathing.. Annals of biomedical engineering, 19 (6), 723-42.
Weir, R., Saidel, G. M., & Jones, S. M. (1990). Optimal design of a thermistor probe for surface measurement of cerebral blood flow.. IEEE transactions on bio-medical engineering, 37 (12), 1159-72.
Saidel, G. M., & Jepson, S. M. (1990). Control and evaluation of high-frequency jet ventilation: mechanical lung model.. Journal of biomedical engineering, 12 (6), 496-502.
ElHefnawy, A., Saidel, G. M., Bruce, E. M., & Cherniack, N. M. (1990). Stability analysis of CO2 control of ventilation.. Journal of applied physiology (Bethesda, Md. : 1985), 69 (2), 498-503.
Tsai, C., Saidel, G. M., McFadden, Jr, E. M., & Fouke, J. M. (1990). Radial heat and water transport across the airway wall.. Journal of applied physiology (Bethesda, Md. : 1985), 69 (1), 222-31.
Guzy, S., Saidel, G. M., & Lotan, N. M. (1990). Multimolecular process in a packed-bed immobilized enzyme reactor: numerical simulation and back-mixing effects.. Biotechnology progress, 6 (2), 98-103.
Davies, C., Malchesky, P., & Saidel, G. M. (1990). Temperature and albumin effects on adsorption of bilirubin from standard solution using anion-exchange resin.. Artificial organs, 14 (1), 14-9.
Ben-Haim, S., Shofti, R., Dinnar, U., & Saidel, G. M. (1990). Pressures generated by rib cage and abdominal compressions during cardiopulmonary resuscitation.. Medical & biological engineering & computing, 28 (1), 43-9.
Ben-Haim, S., & Saidel, G. M. (1990). Mathematical model of chest wall mechanics: a phenomenological approach.. Annals of biomedical engineering, 18 (1), 37-56.
Huebner, W., Saidel, G. M., & Leigh, R. M. (1990). Nonlinear parameter estimation applied to a model of smooth pursuit eye movements.. Biological cybernetics, 62 (4), 265-73.
Dexter, F., Saidel, G. M., & Rudy, Y. M. (1989). Simulation of the diffusion of acetylcholine in the neuroeffector junctions of the sinus node.. Journal of theoretical biology, 141 (4), 505-14.
Ben-Haim, S., Lichtenstein, O., & Saidel, G. M. (1989). Mechanical analysis of extrapulmonary volume displacements in the thorax and abdomen.. Journal of applied physiology (Bethesda, Md. : 1985), 67 (5), 1785-90.
Dexter, F., Saidel, G. M., Levy, M. M., & Rudy, Y. M. (1989). Mathematical model of dependence of heart rate on tissue concentration of acetylcholine.. The American journal of physiology, 256 (2 Pt 2), H520-6.
Ben-Haim, S., & Saidel, G. M. (1989). Chest wall mechanics: effects of acute and chronic lung disease.. Journal of biomechanics, 22 (6-7), 559-64.
Ben-Haim, S., Dinnar, U., & Saidel, G. M. (1988). Optimal design of mechanical ventilator waveform using a mathematical model of the ventilatory system.. Medical & biological engineering & computing, 26 (4), 419-24.
Primiano, Jr, F., Saidel, G. M., Montague, Jr, F. M., Kruse, K. M., Green, C. M., & Horowitz, J. M. (1988). Water vapour and temperature dynamics in the upper airways of normal and CF subjects.. The European respiratory journal, 1 (5), 407-14.
ElHefnawy, A., Saidel, G. M., & Bruce, E. M. (1988). CO2 control of the respiratory system: plant dynamics and stability analysis.. Annals of biomedical engineering, 16 (5), 445-61.
Saidel, G. M., & Modarreszadeh, M. M. (1987). Pulmonary diffusing capacity in the presence of ventilation inhomogeneity.. Journal of applied physiology (Bethesda, Md. : 1985), 63 (6), 2438-49.
Talbot-Pedersen, A., Neuman, M., Saidel, G. M., & Jacobsen, E. M. (1987). Estimation of the determinants of transcutaneous oxygen tension using a dynamic computer model.. Advances in experimental medicine and biology, 220 , 269-73.
Saidel, G. M., Morrison, R. M., & Chisolm, 3rd, G. M. (1987). Transport of macromolecules in arterial wall in vivo: a mathematical model and analytical solutions.. Bulletin of mathematical biology, 49 (2), 153-69.
Lutchen, K., & Saidel, G. M. (1986). Estimation of mechanical parameters in multicompartment models applied to normal and obstructed lungs during tidal breathing.. IEEE transactions on bio-medical engineering, 33 (9), 878-87.
Saidel, G. M., & Lin, Y. M. (1986). Transport abnormalities from single-breath dynamics of Ar, CO2 and O2.. Respiration physiology, 64 (3), 253-66.
Ligas, J., Saidel, G. M., & Primiano, Jr, F. M. (1985). Parameter estimation and sensitivity analysis of a nonlinearly elastic static lung model.. Journal of biomechanical engineering, 107 (4), 315-20.
Chandhoke, P., Saidel, G. M., & Knepper, M. M. (1985). Role of inner medullary collecting duct NaCl transport in urinary concentration.. The American journal of physiology, 249 (5 Pt 2), F688-97.
Swidwa, D., Montenegro, H., Goldman, M., Lutchen, K., & Saidel, G. M. (1985). Helium-oxygen breathing in severe chronic obstructive pulmonary disease.. Chest, 87 (6), 790-5.
Nathanson, M., & Saidel, G. M. (1985). Multiple-objective criteria for optimal experimental design: application to ferrokinetics.. The American journal of physiology, 248 (3 Pt 2), R378-86.
Deychakiwsky, Y., Deal, Jr, E., & Saidel, G. M. (1985). Ventilatory inhomogeneity associated with acute bronchoconstriction in asthmatic patients.. Respiration; international review of thoracic diseases, 47 (3), 201-8.
Lutchen, K., Saidel, G. M., Primiano, Jr, F. M., Horowitz, J. M., & Deal, Jr, E. M. (1984). Mechanics and gas distribution in normal and obstructed lungs during tidal breathing.. The American review of respiratory disease, 130 (6), 974-9.
Felton, C., Saidel, G. M., & Montenegro, H. M. (1984). Moment analysis of multibreath nitrogen washout with a variable input gas composition.. Medical & biological engineering & computing, 22 (6), 486-92.
Montague, Jr, F., Primiano, Jr, F., & Saidel, G. M. (1984). Dynamic water vapor and temperature calibration system.. Journal of applied physiology: respiratory, environmental and exercise physiology, 56 (6), 1675-8.
Primiano, Jr, F., Montague, Jr, F., & Saidel, G. M. (1984). Measurement system for respiratory water vapor and temperature dynamics.. Journal of applied physiology: respiratory, environmental and exercise physiology, 56 (6), 1679-85.
Nathanson, M., McLaren, G., & Saidel, G. M. (1984). A model of intestinal iron absorption and plasma iron kinetics: optimal parameter estimates for normal dogs.. Computers and biomedical research, an international journal, 17 (1), 55-70.
Felton, C., Montenegro, H., & Saidel, G. M. (1984). Inspiratory flow effects on mechanically ventilated patients: lung volume, inhomogeneity, and arterial oxygenation.. Intensive care medicine, 10 (6), 281-6.
Ligas, J., Primiano, Jr, F., & Saidel, G. M. (1984). Static mechanics of excised whole lung: pleural mechanics.. Annals of biomedical engineering, 12 (5), 437-48.
Ligas, J., Primiano, Jr, F., & Saidel, G. M. (1984). Static mechanics of excised whole lung: theoretical framework and experimental studies.. Annals of biomedical engineering, 12 (5), 421-35.
Burma, G., & Saidel, G. M. (1983). Pulmonary blood flow and tissue volume: model analysis of rebreathing estimation methods.. Journal of applied physiology: respiratory, environmental and exercise physiology, 55 (1 Pt 1), 205-11.
Saidel, G. M., Kruse, K. M., & Primiano, Jr, F. M. (1983). Model simulation of heat and water transport dynamics in an airway.. Journal of biomechanical engineering, 105 (2), 188-93.
Salmon, R., Saidel, G. M., Primiano, Jr, F. M., Niewoehner, D. M., & Chester, E. M. (1983). Ventilation inhomogeneity: alveolar mechanics and gas distribution.. Journal of biomechanics, 16 (12), 993-1002.
Salmon, R., Saidel, G. M., Inkley, S. M., & Niewoehner, D. M. (1982). Relationship of ventilation inhomogeneity to morphologic variables in excised human lungs.. The American review of respiratory disease, 126 (4), 686-90.
Lutchen, K., & Saidel, G. M. (1982). Sensitivity analysis and experimental design techniques: application to nonlinear, dynamic lung models.. Computers and biomedical research, an international journal, 15 (5), 434-54.
Lutchen, K., Primiano, Jr, F., & Saidel, G. M. (1982). Nonlinear model combining pulmonary mechanics and gas concentration dynamics.. IEEE transactions on bio-medical engineering, 29 (9), 629-41.
Saidel, G. M. (1982). Alveolar-capillary diffusion and ventilation-perfusion inhomogeneity: a mathematical model.. Medical & biological engineering & computing, 20 (3), 269-73.
Salmon, R., Primiano, Jr, F., Saidel, G. M., & Niewoehner, D. M. (1981). Human lung pressure-volume relationships: alveolar collapse and airway closure.. Journal of applied physiology: respiratory, environmental and exercise physiology, 51 (2), 353-62.
Saidel, G. M., & Burma, G. M. (1981). Multibreath tracer species dynamics in the lung.. Bulletin of mathematical biology, 43 (1), 1-19.
Saidel, G. M. (1981). Species transport dynamics for clinical pulmonary evaluation.. Annals of biomedical engineering, 9 (5-6), 529-41.
Primiano, Jr, F., & Saidel, G. M. (1981). Engineers and the respiratory system: a perspective.. Annals of biomedical engineering, 9 (5-6), 393-4.
Saidel, G. M., Saniie, J. M., & Chester, E. M. (1980). Lung washout during spontaneous breathing: parameter estimation with a time-varying model.. Computers and biomedical research, an international journal, 13 (5), 446-57.
Fleming, G., Chester, E., Saniie, J., & Saidel, G. M. (1980). Ventilation inhomogeneity using multibreath nitrogen washout: comparison of moment ratios and other indexes.. The American review of respiratory disease, 121 (5), 789-94.
Saniie, J., Saidel, G. M., & Chester, E. M. (1979). Real-time moment analysis of pulmonary nitrogen washout.. Journal of applied physiology: respiratory, environmental and exercise physiology, 46 (6), 1184-90.
Palatt, P., & Saidel, G. M. (1979). Modeling and parameter estimation of yeast size distribution dynamics.. Annals of biomedical engineering, 7 (1), 45-57.
Buerk, D., & Saidel, G. M. (1978). Local kinetics of oxygen metabolism in brain liver tissues.. Microvascular research, 16 (3), 391-405.
Saidel, G. M., Saniie, J. M., & Chester, E. M. (1978). Modeling and moments of multibreath lung washout.. Annals of biomedical engineering, 6 (2), 126-37.
Knepper, M., Danielson, R., Saidel, G. M., & Composto, R. M. (1977). Quantitative analysis of renal medullary anatomy in rats and rabbits.. Kidney international, 12 (5), 313-23.
Buerk, D., & Saidel, G. M. (1977). A comparison of two nonclassical models for oxygen consumption in brain and liver tissue.. Advances in experimental medicine and biology, 94 , 225-32.
Ligas, J., Primiano, Jr, F., Saidel, G. M., & Doershuk, C. M. (1977). Comparison of measures of forced expiration.. Journal of applied physiology: respiratory, environmental and exercise physiology, 42 (4), 607-13.
Liotta, L., Saidel, G. M., & Kleinerman, J. M. (1977). Diffusion model of tumor vascularization and growth.. Bulletin of mathematical biology, 39 (1), 117-28.
Liotta, L., Kleinerman, J., & Saidel, G. M. (1976). Mechanism of Bacillus Calmette-Guérin-induced suppression of metastases in a poorly immunogenic fibrosarcoma.. Cancer research, 36 (9 pt.1), 3255-9.
Liotta, L., Saidel, G. M., & Kleinerman, J. M. (1976). Stochastic model of metastases formation.. Biometrics, 32 (3), 535-50.
Saidel, G. M., & Chester, E. M. (1976). Breathing pattern effects on pulmonary oxygen uptake.. Medical & biological engineering, 14 (4), 402-7.
Knepper, M., Saidel, G. M., & Palatt, P. M. (1976). Mathematical model of renal regulation of urea excretion.. Medical & biological engineering, 14 (4), 408-26.
Saidel, G. M., Liotta, L. M., & Kleinerman, J. M. (1976). System dynamics of metastatic process from an implanted tumor.. Journal of theoretical biology, 56 (2), 417-34.
Knepper, M., Danielson, R., Saidel, G. M., & Johnston, K. M. (1975). Effects of dietary protein restriction and glucocorticoid administration on urea excretion in rats.. Kidney international, 8 (5), 303-15.
Saidel, G. M., Salmon, R. M., & Chester, E. M. (1975). Moment analysis of multibreath lung washout.. Journal of applied physiology, 38 (2), 328-34.
Liotta, L., Kleinerman, J., & Saidel, G. M. (1974). Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation.. Cancer research, 34 (5), 997-1004.
Palatt, P., & Saidel, G. M. (1973). Countercurrent exchange in the inner renal medulla: vasa recta- descending limb system.. Bulletin of mathematical biology, 35 (4), 431-47.
Palatt, P., & Saidel, G. M. (1973). An analysis of countercurrent exchange with emphasis on renal function.. Bulletin of mathematical biology, 35 (3), 275-86.
Saidel, G. M., Militano, T. M., & Chester, E. M. (1973). A theoretical basis for assessing pulmonary membrane transport. Continuous CO monitoring during a single-breath maneuver.. Bulletin de physio-pathologie respiratoire, 9 (2), 481-96.
Saidel, G. M., Militano, T. M., & Chester, E. M. (1972). Mass-balance model of pulmonary oxygen transport.. IEEE transactions on bio-medical engineering, 19 (3), 205-13.
Saidel, G. M., Militano, T. M., & Chester, E. M. (1971). Pulmonary gas transport characterization by a dynamic model.. Respiration physiology, 12 (3), 305-28.
Palatt, P., Saidel, G. M., & Macklin, M. M. (1970). Transport processes in the renal cortex.. Journal of theoretical biology, 29 (2), 251-74.
Saidel, G. M. (1968). Bacterial cell populations in a continuously changing environment.. Journal of theoretical biology, 19 (3), 287-96.