Anant Madabhushi, professor of biomedical engineering and a member of the Case Comprehensive Cancer Center, has been awarded U.S. patent 8,774,479, titled “System and method for automated segmentation, characterization and classification of possibly malignant lesions and stratification of malignant tumors.”
The invention relates to a method and software for segmentation and classification of tumors automatically identified on radiologic imaging. The methodology involves computerized extraction of features on imaging that can characterize the risk and malignancy of the lesion.
Co-inventors include Shannon Agner (Washington University, St Louis) and Mark Rosen (University of Pennsylvania).
For some students, an assignment ends with the final grade. For Allison Kipling, the assignment was just a place to start—she’s parlaying her graduate school education into a real-world business.
Kipling is a second-year student in Case Western Reserve University’s master’s degree track in translational health technology within the Department of Biomedical Engineering. Earlier this year, she and her classmates launched a company to take what started as a class project into the medical marketplace.
Researchers with the Advanced Platform Technology (APT) Center of Excellence at Case Western Reserve University and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center have received a $2.6 million award from the National Institutes of Health to develop and deploy new, high resolution nerve cuff electrodes that will allow individuals paralyzed by spinal cord injuries to stand and step through the actions of their own contracting muscles. Ronald Triolo, professor of orthopaedics and biomedical engineering, and Dustin Tyler, associate professor of biomedical engineering, are co-principal investigators on the four-year study, entitled “Enhancing Neuroprosthesis Performance with Nerve Cuff Electrodes,” which will translate their prior work on the engineering design and biocompatibility of the new devices into first-in-human clinical application.
Pallavi Tiwari, research assistant professor, and Anant Madabhushi, professor of biomedical engineering, were awarded a Phase II Coulter award on their project “NeuroRadVisionTM: Image based risk assessment for presence of recurrent tumor or radiation effects on MRI” at the Center for Computational Imaging and Personalized Diagnostics (CCIPD) in Biomedical Engineering. Tiwari is the principal investigator and Madabhushi is the co-investigator on the project.
The $130,000 project is a continuation of the Phase I award for identifying quantitative sub-visual MRI markers to distinguish radiation necrosis from recurrent brain tumors, a challenging problem in clinical management of brain tumor patients. Researchers from the Case Western Reserve University School of Medicine, including Lisa Rogers, professor of neurology, Leo Wolansky, professor of radiology, and Mark Cohen, professor of pathology, serve as clinical co-investigators on the project.
Guanping Yu, a postdoctoral researcher in the lab of Zheng-Rong Lu, the M. Frank and Margaret Domiter Rudy Professor of Biomedical Engineering, has been awarded a $60,000 Career Starter Research Grant from the Knights Templar Eye Foundation (KTEF) to explore treatments for Stargardt disease.
Stargardt disease is the most common form of juvenile retinal macular degeneration and affects one in 10,000 people in the United States. Currently, there is no cure for the disease and little that can be done to prevent, halt or slow the process of vision loss.
Yu will use the KTEF grant to explore new therapeutics that can decrease the accumulation of a compound called all-trans-retinal (atRAL), which is a key factor in the onset of Stargardt disease.