Tau Beta Pi is the only engineering honor society representing the entire engineering profession. It is the nation's second-oldest honor society, with a mission to recognize those who have conferred honor upon their alma mater by distinguished scholarship and exemplary character as students in engineering. The Case Western Reserve chapter hosts peer tutoring sessions, professional development workshops and service events.

Case Western Reserve University's Society of Women Engineers chapter is an educational and service-oriented professional organization that promotes the development of women in STEM fields at the collegiate and professional levels. The group strives to work with women in engineering at the university to develop well-rounded individuals through technical and leadership growth.

The Society of Hispanic Professional Engineers (SHPE) chapter at Case Western Reserve University is an organization that allows students to network, learn and create change for the next generation.

W8EDU is the amateur ham radio club of Case Western Reserve University. Unlike the university's WRUW radio station, which broadcasts radio for public listening, ham radio operators transmit on the radio to communicate with one another. Ham radio operators make contacts around the world, and include many diverse hobby groups.

Phi Sigma Rho is a social sorority for women in engineering and engineering technology that helps members develop the highest standard of personal integrity, strive for academic excellence, and build friendships that will last a lifetime.

The National Society of Black Engineers is a student chapter that is dedicated to promoting professionalism; supporting and retaining minorities in STEM fields; excelling in community oureach and enhancing chapter-wide networking.

CWRU MedWish, in partnership with MedWish International—a Cleveland-based organization—helps sort, test and repair used medical equipment that is being sent for use in developing countries. CWRU MedWish provides a great opportunity for hands-on experience with medical equipment and is open to anyone who wants to join.

This student group works in conjunction with Engineers Without Borders and is committed to improving the well-being of disadvantaged populations through engineering.

Design for America (DFA) is an award-winning nationwide network of interdisciplinary student teams and community members using design to create local and social impact. DFA students use the design process to create and implement solutions to real-world problems.

The Case Rocket Team, which is always looking for new members, participates in high-power rocketry competitions and other aerospace-related events in the area and throughout the nation, including the annual Battle of the Rockets (BotR) competition.