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EECS500 Spring 2016 Department Colloquium

Presenter: 
Sam Neymotin***CANCELLED***
Title: 
Dynamics in multiscale models of neural systems
Affiliation: 
State University of New York
Location: 
White 411
Time: 
11:30am-12:30pm
Date: 
April 19, 2016

Neuronal persistent activity has been primarily assessed in terms of electrical mechanisms, without attention to the complex array of molecular events that also control cell excitability. We developed a multiscale neocortical model proceeding from the molecular to the network level to assess the contributions of calcium (Ca2+) regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in providing additional and complementary support of continuing activation in the network. The network contained 776 compartmental neurons arranged in the cortical layers. Interactions between metabotropic and ionotropic inputs to the neuron demonstrated how multiple pathways could contribute in a complementary manner to persistent activity. Such redundancy and complementarity via multiple pathways is a critical feature of biological systems. Mediation of activation at different time scales, and through different pathways, would be expected to protect against disruption, in this case providing stability for persistent activity.    

Biography: 

Samuel Neymotin Neurosim Lab, SUNY Downstate Medical Center, Brooklyn, New York  (samn@neurosim.downstate.edu). Dr. Neymotin is a Research Assistant Professor in the Physiology & Pharmacology Department at SUNY Downstate Medical Center.  He received a B.S. degree in computer science  from Queens College in 2001, M.S. in computer science from Columbia University in 2005, and Ph.D. degree in biomedical engineering from SUNY Downstate/NYU-Poly in 2012, focusing on computational neuroscience research.  After graduation, he joined Yale University as a postdoctoral associate in Neurobiology. Afterward, he joined SUNY Downstate as Research Assistant Professor, where he has continued his computational neuroscience research.