EECS500 Spring 2012 Seminar

Nicholas Beckloff, Ph.D.
Next Generation Sequencing Data: Ride the Wave
Case Western Reserve University
White Bldg., Room 411
11:30am - 12:30pm
February 2, 2012

Rapid advances in DNA sequencing and associated technologies are ushering in an era of “-Omics” technologies. By itself Next Generation Sequencing (NGS) has revolutionized the field of genomic research making it possible for every individual to have access to their own personal genomes. While this holds great therapeutic potential we are struggling to keep up as the sheer volume of data has outpaced Moore’s, Kryder’sand Nielson’s laws. As the cost of sequencing drops and the output continues to grow, we are constantly searching for new algorithms to manage and analyze the data that is produced.


Nick graduated in 2007 from UMDNJ-Newark with a PhD in Computational Biology where he studied defensinsand synthetic antimicrobial peptide mimetics. Afterwards he spent the next 3 years in the Washington DC area as a contractor working for various organizations including the NCBI and Lockheed Martin. From Bethesda he moved onto New Mexico where he did a post-doc at Los Alamos National Labs working in the B6 Genome Sciences group studying metagenomics. At LANL he investigated transcriptional regulation of host-pathogen interactions using RNA-Seqas well as developing various protocols and workflows for NGS.