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Development and control of brain-computer-interface (BCI) technologies for restoring function to individuals who have experienced severely debilitating injuries to the nervous system, such as spinal cord injury and stroke
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Cleveland Clinic Lerner Research Institute Parkinson's disease; deep brain stimulation; forced exercise; assisted exercise; stroke; robotics; concussion assessment |
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James M. Anderson, M.D., Ph.D. Blood and tissue/material interactions as they relate to implantable devices and biomaterials; The cellular and humoral responses to implanted materials
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Cleveland Clinic Lerner Research Institute Extracellular matrix; connective tissue; proteolysis; metalloproteinases; ADAMTS proteases; proteomics; morphogenesis; cardiovascular disorders; musculoskeletal disorders; birth defects; fetal-maternal medicine; eye disorders; neural tube defects; craniofacial development; smooth muscle; post-translational modification; connective tissue disorders; osteoarthritis; primary cilium. |
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High resolution imaging of endogenous gene expression; definition of "molecular signatures" for imaging and treatment of cancer and other diseases; generating and utilizing genomic data to define informative targets; strategies for applying non-invasive imaging to drug development; and novel molecular imaging probes and paradigms |
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Cleveland Clinic Lerner Research Institute Joint biomechanics; joint injury and post-traumatic osteoarthritis; magnetic resonance imaging of connective tissues; anterior cruciate ligament; biplane videoradiography |
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To develop an understanding for how the neuroinflammatory response facilitates acute and long-term neural device performance.
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Control of neuroprostheses for restoration of motor function; neuromechanics; and modeling of neuromusculoskeletal systems |
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Cleveland Clinic Lerner Research Institute Urinary incontinence; pelvic floor disorders; fecal incontinence; pelvic organ prolapse; peripheral nerve injury; stem cell; regenerative medicine; electrical stimulation; pressure measurement; neurotrophin; animal models; bladder function; urethra; vagina; urodynamics |
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Cleveland Clinic Lerner Research Institute Rotator cuff repair; abdominal wall repair; musculoskeletal soft tissue repair; ECM scaffolds; extracellular matrix; muscle fatty atrophy |
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Professor and Assistant Chair; medical device design, microfabrication packaging, sensor systems, and cross-platform software systems integration.
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Neural engineering; neural interfacing; neural prostheses; computational neuroscience; neural dynamics; neuromodulation; neurophysiology and control of epilepsy
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Biomaterials; instrumentation; nanoscale structure-function analysis of orthopaedic biomaterials; and scanning probe microscopy and spectroscopy of skeletal tissues
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Cleveland Clinic Lerner Research Institute Biomechanics; tissue mechanics; musculoskeletal; movement; locomotion; modeling; simulation; computation; finite element analysis; optimization; multiscale analysis; simulation-based medicine |
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Translational Research; Commercialization; Medical Devices; Orthopedics; Biomechanics; Pre-clinical and Clinical Research
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Cleveland Clinic Lerner Research Institute Biosensors; cell detection; imaging; IVUS; intravascular ultrasound; MEMS; microfluidics; nanotechnology; ultrafiltration; ultrasonic transducer |
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Kiyotaka Fukamachi, M.D., Ph.D. Cleveland Clinic Lerner Research Institute Mechanical circulatory support; ventricular assist device (VAD); total artificial heart (TAH); cardiac function; pressure-volume loop; hemodynamics; heart failure; neurostimulation; mitral valve |
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Cleveland Clinic Lerner Research Institute Blood-brain barrier; drug delivery; in vitro models; drug resistance; brain development; epileptogenesis; ischemic stroke; inflammation; traumatic brain injury; American football; childhood trauma; concussion |
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Biomedical sensing and diagnostics in vitro and in vivo; electrochemical and optical techniques; BioMEMS for cellular transport; cancer multi-drug resistance at the single cell level; and sliver sensor for multi-analyte patient monitoring |
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Neural engineering; neural prostheses; neurophysiology and neural control of genitourinary function; devices to restore genitourinary function; and functional neuromuscular stimulation
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Cleveland Clinic Lerner Research Institute Hyaluronan in inflammation; asthma; diabetes; autophagy; hyperglycemia; connective tissue biology |
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Focuses on developing new technology and therapies for autonomic dysfunction, congenital heart defects, and opioid-induced disorders. Advancement categories: infrared neuromodulation, imaging, and drug development. |
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Cleveland Clinic Lerner Research Institute Diabetes; pancreas development; insulin-producing cells; stem cell therapy |
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Efstathios (Stathis) Karathanasis, Ph.D. Cancer nanotechnology; Pediatric nanomedicine; Therapeutics for brain tumors; Targeted treatments for metastatic disease; Multi-ligand nanoparticles; Precise targeting of disease; Contrast agents for MR, CT and nuclear imaging; Molecular imaging |
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Restoration of movement using neuroprostheses; neuroprosthesis control system design; natural control of human movements; biomechanics of movement; computer-based modeling; and system identification
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Cleveland Clinic Lerner Research Institute Light-nanomaterial interactions for biomedical applications; multifunctional nanomaterials for non-invasive image-guided cancer treatment; nanotherapeutics for prevention of cancer; novel, long-lasting sunscreens |
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Cleveland Clinic Lerner Research Institute Nanomedicine; nanoparticles; cancer metastasis; drug delivery; stroke; spinal cord injury, retinitis pigmentosa, peripheral artery disease |
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Cleveland Clinic Lerner Research Institute Magnetic resonance (MR) and MR spectroscopic imaging in musculoskeletal disorders; clinically oriented quantitative imaging; early detection of cartilage degeneration; marrow adiposity and osteoporosis; rheumatoid and osteoarthritis; joint injury; Program for Advanced Medical Imaging |
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Drug delivery and molecular imaging; novel targeted imaging agents for molecular imaging; novel MRI contrast agents; image-guided therapy and drug delivery; polymeric drug delivery systems; multi-functional delivery systems for nucleic acids |
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Magnetic Resonance Imaging (MRI); Magnetic Resonance Fingerprinting ; Quantitative MR; MR Acquisition and Modeling;Neuroimaging
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Quantitative image analysis; Multi-modal, multi-scale correlation of massive data sets for disease diagnostics, prognostics, theragnostics: cancer applications.
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Cleveland Clinic Lerner Research Institute Sensory integration with prosthetic devices; amputee research; cognitive embodiment; visual-tactile integration; sensory neurophysiology; brain organization; neural plasticity; kinesthesia; diabetic sensory neuropathy |
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Cleveland Clinic Lerner Research Institute Skin cancer; photodynamic therapy; light therapy; wound healing; inflammation; fibrosis; extracellular matrix |
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Chronic high-frequency electrical stimulation of subcortical brain structures-- or deep brain stimulation (DBS)-- and its applications as a therapy for neurological disorders.
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Cleveland Clinic Lerner Research Institute Hepatocellular cancer; local drug delivery; image-guided therapy; endovascular therapy |
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Cleveland Clinic Lerner Research Institute Skeletal biology; bone formation; metabolic bone disease; fracture healing; microgravity; space medicine; mechanical unloading |
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Development of an electronic textbook for Applied Neural Control and understanding the electron transfer processes occurring on platinum neural stimulating electrodes. |
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Cleveland Clinic Lerner Research Institute Stem cell; progenitor cell; bone; cartilage; arthritis; aging; osteoporosis; bone loss; fracture non-union; blood; bone marrow; regenerative medicine; tissue engineering; gender differences; cell therapy; cell processing; orthopaedics; orthopaedic surgery; rheumatology; rehabilitation; quality; clinical outcomes; joint replacement |
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Cleveland Clinic Lerner Research Institute Quantitative image analysis; multiple sclerosis (MS); magnetic resonance imaging (MRI); brain atrophy; MRI-pathology correlations; neuroimaging; brain imaging; MS clinical trials; image processing; machine learning |
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Rehabilitation engineering in spinal cord injury; neural prostheses; and functional electrical stimulation and technology transfer
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Cleveland Clinic Lerner Research Institute Aging; brain; brain damage; brain plasticity; cancer-related fatigue; chemo brain; functional magnetic resonance imaging (fMRI); hemianopia (vision defect); motor control; motor imagery; motor learning; motor cortex; motor mapping of brain; noninvasive brain stimulation; spinal cord injury; stroke; transcranial direct current stimulation; transcranial magnetic stimulation; neuroimaging; neuromodulation; neurorehabilitation; visual cortex; visual field loss |
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Cleveland Clinic Lerner Research Institute Cardiovascular tissue engineering; elastic matrix regenerative repair; abdominal aortic aneurysms; cell-matrix interactions; nanoparticles; drug delivery; electrospinning technologies; stem cells for matrix engineering; vascular cell signaling in disease |
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Biomedical optics; real-time in-vivo microstructural, functional, and molecular imaging using optical coherence tomography; diagnosis and guided therapy for cancer, cardiovascular, and ophthalmic disease
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Mass and heat transport and metabolism in cells, tissues, and organ systems; mathematical modeling and simulation of dynamic and spatially distributed systems; optimal nonlinear parameter estimation and design of experiments
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Targeted drug delivery; targeted molecular imaging; image-guided therapy; platelet substitutes; novel polymeric biomaterials for tissue engineering scaffolds
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The Senyo Laboratory seeks to elucidate factors that regulate basal tissue injury response and early development to devise effective strategies for therapeutic regeneration, particularly in the heart. We approach this goal at several levels by integrating information derived from cross-disciplinary techniques of molecular biology, biophysics, polymer chemistry and biomimicry. |
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Development of minimally invasive neural interfaces for lower risk, lower cost, and higher impact applications in bioelectronic medicine and neural prostheses; other areas of interest include neuroanatomy and physiology, biomaterials, drug delivery, and inflammation.
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Computerized decision support methods for evaluating disease presence and treatment response of radiotherapy and laser ablation therapy for neurological applications: brain tumors, epilepsy, and cancer pain. Novel automated algorithms to analyze and integrate multi-modal imaging data for disease diagnosis, prognosis, and treatment evaluation. |
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Restore/ or enhance the upright and seated mobility, posture and balance in individuals with neuro-musculo-skeletal disorders.
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Sensory restoration; human-machine symbiosis; neuromimetic neuroprostheses; laryngeal neuroprostheses; clinical implementation of nerve electrodes; cortical neuroprostheses; minimally invasive implantation techniques; and modeling of neural stimulation and neuroprostheses |
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Cleveland Clinic Lerner Research Institute Cardiovascular imaging; stroke; histology; image and signal processing; atherosclerosis |
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Medical image analysis, image radiomics, and machine learning schemes, focused on the use of post-processing, co-registration, and biological quantitation of imaging data. Applications in image-guided interventions, predictive guidance, and quantitative treatment response characterization in gastrointestinal cancers and inflammatory diseases. |
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Affinity-based delivery of small molecule drugs and biomolecules for applications in device infection, HIV, orthopedics, cardiovascular, ophthalmology and cancer; directed differentiation of stem cells for tissue engineering applications, such as endothelial cells, cardiomyocytes, motor neurons and T-cells |
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Biomedical image processing; digital processing and quantitative image quality of X-ray fluoroscopy images; interventional MRI
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Magnetic resonance imaging and spectroscopy; Metabolic imaging; Diabetes, obesity and metabolic syndrome; Stroke; Blood-brain barrier; Glymphatic function; Cerebrovascular physiology; Neuroimaging; Cardiac MRI |
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Cleveland Clinic Lerner Research Institute Cell separation; magnetic cell sorting; magnetic nanoparticles; immunomagnetic cell labeling; tissue magnetic susceptibility; red blood cell magnetic susceptibility; cell magnetophoresis; biomagnetism; intracellular iron; iron metabolism; circulating tumor cell separation; tissue progenitor cell separation; stem cell separation; particle tracking velocimetry; cell tracking velocimetry |
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Nanotechnology for Cancer Diagnosis and Treatment; Imaging and Manipulation of Tumor Microenvironment; Cancer Immunotherapy; Adoptive T cell Immunotherapy |
