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Development and control of brain-computer-interface (BCI) technologies for restoring function to individuals who have experienced severely debilitating injuries to the nervous system, such as spinal cord injury and stroke
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James M. Anderson, M.D., Ph.D. Blood and tissue/material interactions as they relate to implantable devices and biomaterials; The cellular and humoral responses to implanted materials
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High resolution imaging of endogenous gene expression; definition of "molecular signatures" for imaging and treatment of cancer and other diseases; generating and utilizing genomic data to define informative targets; strategies for applying non-invasive imaging to drug development; and novel molecular imaging probes and paradigms |
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To develop an understanding for how the neuroinflammatory response facilitates acute and long-term neural device performance.
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Control of neuroprostheses for restoration of motor function; neuromechanics; and modeling of neuromusculoskeletal systems |
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Professor and Assistant Chair; medical device design, microfabrication packaging, sensor systems, and cross-platform software systems integration.
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Neural engineering; neural interfacing; neural prostheses; computational neuroscience; neural dynamics; neuromodulation; neurophysiology and control of epilepsy
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Biomaterials; instrumentation; nanoscale structure-function analysis of orthopaedic biomaterials; and scanning probe microscopy and spectroscopy of skeletal tissues
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Translational Research; Commercialization; Medical Devices; Orthopedics; Biomechanics; Pre-clinical and Clinical Research
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Biomedical sensing and diagnostics in vitro and in vivo; electrochemical and optical techniques; BioMEMS for cellular transport; cancer multi-drug resistance at the single cell level; and sliver sensor for multi-analyte patient monitoring |
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Neural engineering; neural prostheses; neurophysiology and neural control of genitourinary function; devices to restore genitourinary function; and functional neuromuscular stimulation
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Focuses on developing new technology and therapies for autonomic dysfunction, congenital heart defects, and opioid-induced disorders. Advancement categories: infrared neuromodulation, imaging, and drug development. |
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Efstathios (Stathis) Karathanasis, Ph.D. Cancer nanotechnology; Pediatric nanomedicine; Therapeutics for brain tumors; Targeted treatments for metastatic disease; Multi-ligand nanoparticles; Precise targeting of disease; Contrast agents for MR, CT and nuclear imaging; Molecular imaging |
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Restoration of movement using neuroprostheses; neuroprosthesis control system design; natural control of human movements; biomechanics of movement; computer-based modeling; and system identification
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Drug delivery and molecular imaging; novel targeted imaging agents for molecular imaging; novel MRI contrast agents; image-guided therapy and drug delivery; polymeric drug delivery systems; multi-functional delivery systems for nucleic acids |
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Magnetic Resonance Imaging (MRI); Magnetic Resonance Fingerprinting ; Quantitative MR; MR Acquisition and Modeling;Neuroimaging
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Quantitative image analysis; Multi-modal, multi-scale correlation of massive data sets for disease diagnostics, prognostics, theragnostics: cancer applications.
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Chronic high-frequency electrical stimulation of subcortical brain structures-- or deep brain stimulation (DBS)-- and its applications as a therapy for neurological disorders.
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Development of an electronic textbook for Applied Neural Control and understanding the electron transfer processes occurring on platinum neural stimulating electrodes. |
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Rehabilitation engineering in spinal cord injury; neural prostheses; and functional electrical stimulation and technology transfer
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Biomedical optics; real-time in-vivo microstructural, functional, and molecular imaging using optical coherence tomography; diagnosis and guided therapy for cancer, cardiovascular, and ophthalmic disease
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Mass and heat transport and metabolism in cells, tissues, and organ systems; mathematical modeling and simulation of dynamic and spatially distributed systems; optimal nonlinear parameter estimation and design of experiments
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Targeted drug delivery; targeted molecular imaging; image-guided therapy; platelet substitutes; novel polymeric biomaterials for tissue engineering scaffolds
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The Senyo Laboratory seeks to elucidate factors that regulate basal tissue injury response and early development to devise effective strategies for therapeutic regeneration, particularly in the heart. We approach this goal at several levels by integrating information derived from cross-disciplinary techniques of molecular biology, biophysics, polymer chemistry and biomimicry. |
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Development of minimally invasive neural interfaces for lower risk, lower cost, and higher impact applications in bioelectronic medicine and neural prostheses; other areas of interest include neuroanatomy and physiology, biomaterials, drug delivery, and inflammation.
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Computerized decision support methods for evaluating disease presence and treatment response of radiotherapy and laser ablation therapy for neurological applications: brain tumors, epilepsy, and cancer pain. Novel automated algorithms to analyze and integrate multi-modal imaging data for disease diagnosis, prognosis, and treatment evaluation. |
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Restore/ or enhance the upright and seated mobility, posture and balance in individuals with neuro-musculo-skeletal disorders.
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Neuromimetic neuroprostheses; laryngeal neuroprostheses; clinical implementation of nerve electrodes; cortical neuroprostheses; minimally invasive implantation techniques; and modeling of neural stimulation and neuroprostheses |
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Medical image analysis, image radiomics, and machine learning schemes, focused on the use of post-processing, co-registration, and biological quantitation of imaging data. Applications in image-guided interventions, predictive guidance, and quantitative treatment response characterization in gastrointestinal cancers and inflammatory diseases. |
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Affinity-based delivery of small molecule drugs and biomolecules for applications in device infection, HIV, orthopedics, cardiovascular, ophthalmology and cancer; directed differentiation of stem cells for tissue engineering applications, such as endothelial cells, cardiomyocytes, motor neurons and T-cells |
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Biomedical image processing; digital processing and quantitative image quality of X-ray fluoroscopy images; interventional MRI
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Magnetic resonance imaging and spectroscopy; applications of MRI and MRS to cardiovascular research
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