Online Master's in Biomedical Engineering @ Case.edu
Shedding Light on the Nervous System
Capitalizing on Opportunities in Medical Imaging
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BMIL Personnel

Principal Investigator

David L. Wilson, PhD

Current Position and Honors:

  • Robert J. Herbold Professor of Biomedical Engineering and Radiology, School of Engineering and School of Medicine
  • Chief Technology Officer (CTO), Bioinvision Inc.
  • Fellow, American Institute for Medical and Biological Engineering (AIMBE)

Education:

  • PhD (Electrical Engineering), Rice University
  • MS (Biomedical Engineering), Penn State University
  • BS (Physics), West Virginia University

Teaching:

  • EBME410 Medical Imaging Fundamentals
  • EBME461 Biomedical Image Processing and Analysis
  • EBME615 Topic Seminars for Imaging Students I
  • EBME616 Topic Seminars for Imaging Students II

Interests and current researches:

Much of my research involves minimally invasive, interventional medical imaging. In one project, cancerous tumors are tumors are treated with MR-guided RF thermal ablation. My research group is developing 3D registration, segmentation, and visualization imaging is high definition TV viewing of moving objects in the body. This quantum-limited image sequence is quite noisy, and spatio-temporal processing by the human visual system is an extremely important step in the imaging chain. Thus, we study new digital image enhancement techniques using experimental and theoretical image perception evaluations. In yet another application of imaging to treatment, we use high-resolution, 3D MR images to estimate biomechanical parameters in the fingers and wrist in order to plan tendon transfer surgery and functional neuromuscular stimulation (FNS) interventions. Digital image processing can also be applied to nanoscale images, and we are creating techniques using mathematical morphology to improve AFM images of single biomolecules.

Currently (2013), Dr. Wilson's most active research projects include image analysis of intravascular optical coherence tomography (iOCT), computerized tomography (CT) myocardial perfusion and cryo-imaging developement and application.

Contact:

Email: dlw [at] case.edu

Call: (216)-368- 4099 or 8812

My Curriculum Vitae

Postdoctoral Fellows

Madhusudhana Gargesha, PhD

Current Position and Honors:

  • Senior Research AssociateBMIL

Education:

  • PhD (Electrical Engineering), Arizona State University
  • MS (Electrical Engineering), Arizona State University
  • BE (Electronics and Communications Engineering), Bangalore University, India

Interests and current researches:

Dr. Gargesha's current research interests include image preprocessing, analysis and  4D visualization of high-throughput OCT image data from embryonic avian and murine models, and preprocessing and visualization of color cryo-imaging data from small animal models including rats and mice.

Contact:

Email: mxg183 [at] case.edu 

Call: N/A

Curriculum Vitae and website

 

Rachid Fahmi, PhD

Current Position and Honors:

  •  

Education:

  • PhD (Electrical and Computer Engineering), University of Louisville
  • PhD(Applied Mathematics), Université Paul Verlaine, France
  • MSc (Applied Mathematics), Université Paul Verlaine, France
  • BSc (Applied Mathematics), Université Hassan II, France

Interests and current researches:

  • CT Cardiac Perfusion Project

Contact:

Email 

Call: N/A

Curriculum Vitae and website

 
Graduate Students

Mohammed Qutaish, Ph.D. Graduate

Education:

  • Ph.D., Biomedical Engieering, Case Western Reserve University
  • M.S., Biomedical Engineering, Case Western Reserve University
  • B.S., Biomedical Engineering, Jordan University of Science and Technology, Irbid, Jordan.

Interests and current researches:

I’m working on building a platform technology to optimize Cryo-imaging methods and software to provide unique 3D, quantitative characterization of tumor models and assessment of theranostics and imaging agent targeting of dispersing and metastatic tumor. Also, I like watching soccer and playing chess :).

Publications:

  • MQ Qutaish, SM Burden-Gulley, KE Sullivant, M. Tan, SE Craig , JP  Basilion, ZR Lu, DL Wilson, SM Brady-Kalnay, “Single cell molecular recognition of migrating and invading tumor cells using a targeted fluorescent probe to receptor PTPmu”. International Journal of Cancer 2013.
  • M. Qutaish, K. Sullivant, S.M. Burden-Gulley, H. Lu, D. Roy, J. Wang, JP.P. Basilion, S. M. Brady-Kalnay and D. Wilson, “Cryo-image analysis of tumor cell migration,invasion, and dispersal in a mouse xenograft model of human glioblastomamultiforme”,  Molecular Imaging and Biology, 2011.
  • S.M. Burden-Gulley, M. Qutaish, K. Sullivant,  J. Wang, S.E.L Craig, J. P. Basilion, D. Wilson and S.M. Brady-Kalnay, “Novel cryo-imaging of the tumormicroenvironment reveals glioma cell migration and dispersal pathways in vividthree-dimensional detail”, Cancer Research, 2011.
  • M. Gargesha, M. Qutaish, D. Roy, G. Steyer, H. Bartsch and D.L. Wilson. “Visualizationof color anatomy and molecular fluorescence in whole-mouse cryo-imaging”, Computerized Medical Imaging and Graphics (CMIG), Epub in press, 2010.
  • M. Gargesha, M. Qutaish, D. Roy, G. Steyer, H. Bartsch, D. Wilson “Enhancedvolume rendering techniques for high-resolution color cryo-imaging data”, SPIE; Proc Soc Photo Opt Instrum Eng.2009; 7262:72655V.

Contact:

Email: mqq [at] case.edu

profile

 

Patiwet Wuttisarnwattana, MS, PhD Candidate

Current Position and Honors:

  • Full scholarship recipient, from the Royal Thai Government to pursue MS and Ph.D. degrees in BME
  • Lab Webmaster, BMIL
  • Mini Cryo-Imaging Software Developer, BMIL
  • WMIC 2013 Best Poster Presentation Award Winner, WMIC2013, Savannah, GA.
  • SPIE 2014 Best Poster Presentation Award Winner (Cum Laude), SPIE2014, San Diego, CA.

Education:

  • MS (Biomedical Engineering), Case Western Reserve University
  • BEng (Computer Engineering), first class honors, Chiang Mai University, Thailand

Interests and current researches:

My research is to study cell therapy and their bio-distribution in mice including  stem cell bio-distribution, inflammatory cell bio-distribution and microsphere bio-distribution. In many experiments, I injected fluorescent labeled cells as well as non-cellular particles into mice and studied where these cells went and how they interacted with the hosts in various conditions. Currently, I am studying how mesenchymal stem cells (MSCs) and multipotent adult progenitor cells (MAPCs) can suppress T-lymphocyte proliferation in graft-versus-host disease (GVHD). As a biomedical engineer, I have employed many advance technologies such as Cryo-imaging system (invented by our lab), Matlab programming and Amira visualization which enable one to visualize and analyze the data with the whole new scale. Generally, my topics of interest are computer vision and pattern recognition in medical imaging. I am also deeply interested in stem cell therapy and general histopathology. 

Publications & Abstract Submissions:

  •  J.J. Auletta, S. Eid, L. Metheny, M.D. Keller, R. Guardia-Wolff, C. Liu, F. Wang, T. Bowen, P. Wuttisarnwattana, Z. Lee, L.A. Solchaga, D.L. Wilson, K.R. Cooke, "Human mesenchymal stem cells attenuate graft-versus-host disease and maintain graft-versus-leukemia activity following experimental allogeneic bone marrow transplantation",  in press
  • P. Wuttisarnwattana ; S.A. Raza ; S. Eid ; K. R. Cooke and D.L. Wilson "Novel T lymphocyte proliferation assessment using whole mouse cryo-imaging", Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 90381U (March 13, 2014); doi:10.1117/12.2042960
  • P. Wuttisarnwattana, D. Wilson, K. Cooke and S. Eid, “Mesenchymal Stem Cell Immunomodulation Effects on Graft-Versus-Host Disease as Determined with Cryo-imaging”, 2013 World Molecular Imaging Congress, Savannah, GA
  • P. Wuttisarnwattana, M. Gargesha, M. Qutaish, K. Sullivant and D. Wilson, “Stem Cell Detection for Whole-Mouse, Microscopic Cryo-imaging Data”, 2011 World Molecular Imaging Congress, San Diego, CA
  • P. Wuttisarnwattana, M. Gargesha, and D. Wilson, “Stem Cell Detection and Quantification for Cryo-imaging System”, in press
  • P. Wuttisarnwattana, W. Vant Hof, and D. Wilson, Mesenchymal Stem Cell Immunomodulation Effects on Graft-Versus-Host Disease as Determined with Cryo-imaging, in press
  • K. Sullivant, M. Qutaish, P. Wuttisarnwattana, M. Gargesha, S. Katari, H. Lu, A. Deshmane, N. Tenley, J. Molter, S. Eid, J. Auletta, A. Raber, W. Hof , K. Cooke, Z. Lee, and D. Wilson, “Cryo-Imaging and SPECT imaging of Multipotent Adult Progenitor Cells in a Mouse Model of Graft-versus-Host Disease”, 2011 World Molecular Imaging Congress
  • D. Wilson, M. Gargesha, D. Roy, M. Qutaish, G. Krishnamurthi, K. Sullivant,P. Wuttisarnwattana, H. Lu, B. Moore and C. Anderson, “Cryo-imaging of 70+gb mice: image processing/visualization challenges and biotechnology applications”, 2011 IEEE International Symposium on Biomedical Imaging

Contact:

Email: pxw110[at] case.edu

Call: (216)-368-8812 (Lab)

 website

 

Hong Lu, BS, PhD Candidate

Current Position and Honors:

  • Server administratorBMIL

Education:

  • BS (Biomedical Engineering), Tianjin University, China

Interests and current researches:

Biomedical image processing, currently Stent strut analysis using OCT.

Contact:

Email: hxl286 [at] case.edu

David Prabhu, BS, PhD Student

Education:

  • BS (Biomedical Engineering), Case Western Reserve University

Interests and current researches:

Atherosclerosis plaques characterization using OCT and Cryo-imaging

Contact:

Email: dsp15 [at] case.edu

 
Brendan Eck, BS, PhD Student

Education:

  • BS (Physics and Mathematics) summa cum laude, Wright State University, Dayton, OH

Interests and current researches:

My current work is in the development of a CT Myocardial Perfusion scan protocol and software analysis package. My focus is in x-ray dose reduction and perfusion measurement. In dose reduction, we have evaluated lesion detection by human observers in 4-Alternative Forced Choice (4AFC) experiments at nominal and reduced dose with both standard Filtered Back Projection (FBP) and a knowledge-based iterative reconstruction algorithm (Philips IMR). We compared human results to a model observer with good agreement, and continue to develop this observer for reconstruction optimization to reduce the need for time-consuming, costly human observer studies. In perfusion measurement, we employ physiological models with time-activity curves from the arterial input and myocardial tissue to obtain blood flow. Using our Cryo-imaging system we can validate this technique by fluorescent microspheres, and obtain a spatial distribution of spheres in pig hearts. My broader interest is in non- and minimally-invasive diagnostic imaging.

Publications:

  • Wilson,D , Miao,J , Raihani,N , Brown,K , Eck,B , “Quantitative Image Quality Evaluation of Low Dose Iterative Reconstruction”, Radiological Society of North America 2012 Scientific Assembly and Annual Meeting; November 25- November 30, 2012 Chicago IL.

 Contact:

Email: ble14 [at] case.edu

Call: (216)-368-8812 (Lab), (937)-733-1440 (Home)

website

 
Undergraduate Student

 

 
Alumni

Christian Anderson, BS (Class of 2012)

 

 

Jun Miao, PhD (Class of 2012)

Dissertation:

 

Sreenath P Narayan, MD, PhD (Class of 2012)

Dissertation:

Kristin Sullivant, MS (Class of 2011)

Research Topic:

  • Cryo-Image Analysis of Multipotent Adult Progenitor Cells in a Mouse Model of Graft-versus Host Disease
  •  MS Plan B

 

Grant Steyer, PhD (Class of 2010)

Dissertation:

David H. Johnson, PhD (Class of 2010)

Dissertation:

Debashish Roy, PhD (Class of 2010)

Dissertation:

Meredith E. Stone, MS (Class of 2008)

Thesis:

Olivier Salvado, PhD (Class of 2006)

Dissertation:

 For current students and alumni who want to update your information in this list, please contact Patiwet W.