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Innovations in Imaging

Biomedical Imaging Laboratory

The Biomedical Imaging Laboratory, headed by Professor David L. Wilson, Ph.D., conducts premedically and medically relevant research in imaging science and offers training to students. The laboratory has projects funded by research grants from NIH and the Whitaker Foundation.

The laboratory has several graduate students conducting ground-breaking research in the field of image processing. State-of-the-art computing facilities are available, including a number of workstations with programs such as Amira, Matlab, and Analyze, as well as several custom applications developed within the lab. The lab works closely with the Case Center for Imaging Research, which houses state of the art imaging facilities for both human and small animal MRI, CT, PET, SPECT, and small animal bioluminescence and cryo-imaging.

Cryo-imaging is a novel method developed in Dr. Wilson's laboratory that serially sections and images the block face of a frozen specimen, providing ultra-high-resolution RGB and fluorescence volumes. It consists of a mouse-sized cryomicrotome; microscope; low light camera; three-axis robotic positioning system; and automation, visualization, and analysis software. The development of new technology in conjunction with further advances in established imaging applications puts the Biomedical Imaging Laboratory on the forefront of imaging science.

A bright field cryo-image of a whole mouse and 3D visualization. Cryo-imaging enables high resolution 3-D color imaging in bright field and fluorescence with the acquisition of several slices, such as the one pictured above, at 10-40 micrometer intervals.