Active PI / Co-PI Funding
Grant # 2635723 (Capadona) 04/01/2019-3/30/2024
NIH NINDS (R01) $2,500,000 DC
Characterizing and mitigating the role of oxidative damage in microelectrode failure
This project seeks to develop an antioxidative surface coating to prevent premature failure of stimulating intracortical microelectrode which results from oxidative damage to electrode materials and oxidative damage to neural tissue. We will additionally investigate the role of oxidative damage as a fuction of device rigidity.
Role: Co-PI (Pancrazio)
Grant # A3083 (Capadona) 04/01/2019 - 03/31/2023
VA RR&D Merit Review $1,100,000 DC
Hybrid Drug-Eluting Microfluidic Neural Probe for Chronic Drug Infusion
This project seeks to develop a drug eluting intracortical microelectrode from dynaically softening polymer nanocomposite materials. The implants will release the antioxidant Resveratrol, to investigate the impact of target two improtant mechanism for microelectrode failure.
Role: Co-PI (Hess-Dunning)
GRANT # A3077 (Capadona) 01/01/2019 - 12/31/2023
VA RR&D Research Career Scientist $590,184 DC
RR&D Research Career Scientist Award Application
This award is not tied to a project and is granted to top performing VA investigators in recognition of career performance and trajectory within the VA, RR&D service.
Role: PI
Grant # A2611 (Capadona) 07/01/2018 - 06/30/2022 VA RR&D Merit Review $962,327 DC
Antioxidative Microelectrodes to Improve Neural Recording Performance
This project seeks to develop an antioxidative surface coating to prevent premature failure of intracortical microelectrode which results from oxidative damage to elelctrode matierals and oxidative damage to neural tissue.
Role: PI
R01 NS082404 (Capadona) 08/01/2013 - 07/31/2019 (NCE)
NIH NINDS $2,302,414 DC
CD14 facilitates neural device integration and performance
The central hypothesis is that CD14 inhibition will attenuate microelectrode encapsulation and neuronal die-back, resulting in reduced tissue impedance and more stable and higher numbers of isolated unit recordings from implanted microelectrodes. The current proposal will build from the PI's preliminary results indicated the role of CD14 in neural device-associated inflammation. A transgenic rodent intracortical microelectrode model will be used to complete the characterization of the role of CD14 in neuroinflammation. Additionally, novel CD14 antagonist will be further investigated as a therapeutic means to inhibit device-associated neuroinflammation and improve the longevity of device performance. The successful completion of this project will provide clear support for our central hypothesis, and will help facilitate the translation of this promising technology to treat patients.
Role: PI
Grant # 11766813 (Capadona) 09/01/2015 - 08/31/2019 (NCE)
DoD CDMRP $678,532 DC
The Effect of the Elimination of Micromotion and Tissue Strain on Intracortical Device Performance
In this study, we will systematically examine the effects of softening microelectrodes, which reduce the micromotion and tissue strain effects, on the neuroinflammatory response and recording capability of chronically implanted intracortical microelectrodes arrays. When successful, this study will for the first time answer a 30+ year old hypothesis of the field, and provide a framework leading to the development of new generations of implantable cortical interfaces capable of long-term reliability.
Role: Co-PI (Pancrazio)
Active Co-I Funding
Grant # A1871-C (Triolo) 01/01/2015 - 12/31/2019 (renewed for 5 additional years)
VA RR&D Research Center of Excellence $ 5,000,000 DC
Advanced Platform Technology Center of Excellence
Together with basic science and engineering faculty at CWRU, and other notable institutions like the Cleveland Clinic, we leverage the latest advances in microfabrication, microelectronics and microsystems, material science, neuroscience and neural engineering, and additive manufacturing, and apply them to the highest medical priorities of the Veterans Health Administration. Our efforts are concentrated in four primary areas: Enabling Technologies, Neural Interfacing, Health Monitoring/Maintenance and Prosthetics/Orthotics. “Enabling Technologies” refers to the new materials, microfabrication processes, and encapsulation, encoding or sensing methods that make many otherwise intractable clinical applications not only possible, but practical.
Role: Co-I
Grant # 1743475 (Korley) 09/01/2017 - 08/31/2022
National Science Foundation $5,500,000 DC
PIRE: Bio-Inspired Materials and Systems
The PIRE is a multi-institutional International collaboration focusing on the molecular design of materials, with inspirations from natural systems either in the design, or final system.
Role: Co-I
