Active PI / Co-PI Funding

Grant # 2635723 (Capadona)                         04/01/2019-3/30/2024           

NIH NINDS (R01)                                                     $2,500,000 DC

Characterizing and mitigating the role of oxidative damage in microelectrode failure

This project seeks to develop an antioxidative surface coating to prevent premature failure of stimulating intracortical microelectrode which results from oxidative damage to electrode materials and oxidative damage to neural tissue.  We will additionally investigate the role of oxidative damage as a fuction of device rigidity.

Role: Co-PI (Pancrazio)

Grant # A3083 (Capadona)                            04/01/2019 - 03/31/2023

VA RR&D Merit Review                                           $1,100,000 DC

Hybrid Drug-Eluting Microfluidic Neural Probe for Chronic Drug Infusion

This project seeks to develop a drug eluting intracortical microelectrode from dynaically softening polymer nanocomposite materials.  The implants will release the antioxidant Resveratrol, to investigate the impact of target two improtant mechanism for microelectrode failure.

Role: Co-PI (Hess-Dunning)

GRANT # A3077 (Capadona)                                    01/01/2019 - 12/31/2023              

VA RR&D Research Career Scientist                       $590,184 DC

RR&D Research Career Scientist Award Application

This award is not tied to a project and is granted to top performing VA investigators in recognition of career performance and trajectory within the VA, RR&D service. 

Role: PI

Grant # A2611 (Capadona)                                        07/01/2018 - 06/30/2022              VA RR&D Merit Review                                           $962,327 DC

Antioxidative Microelectrodes to Improve Neural Recording Performance

This project seeks to develop an antioxidative surface coating to prevent premature failure of intracortical microelectrode which results from oxidative damage to elelctrode matierals and oxidative damage to neural tissue. 

Role: PI

R01 NS082404 (Capadona)                                      08/01/2013 - 07/31/2019 (NCE)                                

NIH NINDS                                                                $2,302,414 DC

CD14 facilitates neural device integration and performance

The central hypothesis is that CD14 inhibition will attenuate microelectrode encapsulation and neuronal die-back, resulting in reduced tissue impedance and more stable and higher numbers of isolated unit recordings from implanted microelectrodes. The current proposal will build from the PI's preliminary results indicated the role of CD14 in neural device-associated inflammation. A transgenic rodent intracortical microelectrode model will be used to complete the characterization of the role of CD14 in neuroinflammation.  Additionally, novel CD14 antagonist will be further investigated as a therapeutic means to inhibit device-associated neuroinflammation and improve the longevity of device performance. The successful completion of this project will provide clear support for our central hypothesis, and will help facilitate the translation of this promising technology to treat patients.

Role: PI

Grant # 11766813 (Capadona)                                   09/01/2015 - 08/31/2019 (NCE)                            

DoD CDMRP                                                             $678,532 DC

The Effect of the Elimination of Micromotion and Tissue Strain on Intracortical Device Performance

In this study, we will systematically examine the effects of softening microelectrodes, which reduce the micromotion and tissue strain effects, on the neuroinflammatory response and recording capability of chronically implanted intracortical microelectrodes arrays. When successful, this study will for the first time answer a 30+ year old hypothesis of the field, and provide a framework leading to the development of new generations of implantable cortical interfaces capable of long-term reliability.

Role: Co-PI (Pancrazio)

Active Co-I Funding

Grant # A1871-C (Triolo)      01/01/2015 - 12/31/2019 (renewed for 5 additional years)             

VA RR&D Research Center of Excellence   $ 5,000,000 DC

Advanced Platform Technology Center of Excellence

Together with basic science and engineering faculty at CWRU, and other notable institutions like the Cleveland Clinic, we leverage the latest advances in microfabrication, microelectronics and microsystems, material science, neuroscience and neural engineering, and additive manufacturing, and apply them to the highest medical priorities of the Veterans Health Administration.  Our efforts are concentrated in four primary areas:  Enabling Technologies, Neural Interfacing, Health Monitoring/Maintenance and Prosthetics/Orthotics.  “Enabling Technologies” refers to the new materials, microfabrication processes, and encapsulation, encoding or sensing methods that make many otherwise intractable clinical applications not only possible, but practical. 

Role: Co-I

Grant # 1743475 (Korley)                                          09/01/2017 - 08/31/2022                                          

National Science Foundation                         $5,500,000 DC           

PIRE: Bio-Inspired Materials and Systems

The PIRE is a multi-institutional International collaboration focusing on the molecular design of materials, with inspirations from natural systems either in the design, or final system.

Role: Co-I