| Title | Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non-Small Cell Lung Cancer. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Corredor, G, Wang X, Zhou Y, Lu C, Fu P, Syrigos K, Rimm DL, Yang M, Romero E, Schalper KA, Velcheti V, Madabhushi A |
| Journal | Clinical cancer research : an official journal of the American Association for Cancer Research |
| Volume | 25 |
| Issue | 5 |
| Pagination | 1526-1534 |
| Date Published | 2019 Mar 01 |
| ISSN | 1078-0432 |
| Abstract | The presence of a high degree of tumor-infiltrating lymphocytes (TIL) has been proven to be associated with outcome in patients with non-small cell lung cancer (NSCLC). However, recent evidence indicates that tissue architecture is also prognostic of disease-specific survival and recurrence. We show a set of descriptors (spatial TIL, SpaTIL) that capture density, and spatial colocalization of TILs and tumor cells across digital images that can predict likelihood of recurrence in early-stage NSCLC. |
| DOI | 10.1158/1078-0432.CCR-18-2013 |
| PDF Link | |
| Alternate Journal | Clin. Cancer Res. |
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