| Title | Shape Features of the Lesion Habitat to Differentiate Brain Tumor Progression from Pseudoprogression on Routine Multiparametric MRI: A Multisite Study. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Ismail, M, Hill V, Statsevych V, Huang R, Prasanna P, Correa R, Singh G, Bera K, Beig N, Thawani R, Madabhushi A, Aahluwalia M, Tiwari P |
| Journal | AJNR. American journal of neuroradiology |
| Volume | 39 |
| Issue | 12 |
| Pagination | 2187-2193 |
| Date Published | 2018 Dec |
| ISSN | 1936-959X |
| Abstract | Differentiating pseudoprogression, a radiation-induced treatment effect, from tumor progression on imaging is a substantial challenge in glioblastoma management. Unfortunately, guidelines set by the Response Assessment in Neuro-Oncology criteria are based solely on bidirectional diametric measurements of enhancement observed on T1WI and T2WI/FLAIR scans. We hypothesized that quantitative 3D shape features of the enhancing lesion on T1WI, and T2WI/FLAIR hyperintensities (together called the lesion habitat) can more comprehensively capture pathophysiologic differences across pseudoprogression and tumor recurrence, not appreciable on diametric measurements alone. |
| DOI | 10.3174/ajnr.A5858 |
| PDF Link | |
| Alternate Journal | AJNR Am J Neuroradiol |
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