Quantitative nuclear histomorphometry predicts oncotype DX risk categories for early stage ER+ breast cancer.

TitleQuantitative nuclear histomorphometry predicts oncotype DX risk categories for early stage ER+ breast cancer.
Publication TypeJournal Article
Year of Publication2018
AuthorsWhitney, J, Corredor G, Janowczyk A, Ganesan S, Doyle S, Tomaszewski J, Feldman M, Gilmore H, Madabhushi A
JournalBMC cancer
Date Published2018 May 30
KeywordsAdult, Aged, Breast, Breast Neoplasms, Cell Nucleus, Female, Genetic Testing, Humans, Image Processing, Computer-Assisted, Middle Aged, Models, Biological, Neoplasm Staging, Predictive Value of Tests, Principal Component Analysis, Prognosis, Receptors, Estrogen, Risk Factors, ROC Curve, Staining and Labeling, Supervised Machine Learning, Young Adult

Gene-expression companion diagnostic tests, such as the Oncotype DX test, assess the risk of early stage Estrogen receptor (ER) positive (+) breast cancers, and guide clinicians in the decision of whether or not to use chemotherapy. However, these tests are typically expensive, time consuming, and tissue-destructive.

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Alternate JournalBMC Cancer

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