Novel Quantitative Imaging for Predicting Response to Therapy: Techniques and Clinical Applications.

TitleNovel Quantitative Imaging for Predicting Response to Therapy: Techniques and Clinical Applications.
Publication TypeJournal Article
Year of Publication2018
AuthorsBera, K, Velcheti V, Madabhushi A
JournalAmerican Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Date Published2018 May 23
KeywordsCombined Modality Therapy, Diagnostic Imaging, Humans, Lung Neoplasms, Multimodal Imaging, Neoplasms, Prognosis, Treatment Outcome

The current standard of Response Evaluation Criteria in Solid Tumors (RECIST)-based tumor response evaluation is limited in its ability to accurately monitor treatment response. Radiomics, an approach involving computerized extraction of several quantitative imaging features, has shown promise in predicting as well as monitoring response to therapy. In this article, we provide a brief overview of radiomic approaches and the various analytical methods and techniques, specifically in the context of predicting and monitoring treatment response for non-small cell lung cancer (NSCLC). We briefly summarize some of the various types of radiomic features, including tumor shape and textural patterns, both within the tumor and within the adjacent tumor microenvironment. Additionally, we also discuss work in delta-radiomics or change in radiomic features (e.g., texture within the nodule) across longitudinally interspersed images in time for monitoring changes in therapy. We discuss the utility of these approaches for NSCLC, specifically the role of radiomics as a prognostic marker for treatment effectiveness and early therapy response, including chemoradiation, immunotherapy, and trimodality therapy.

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Alternate JournalAm Soc Clin Oncol Educ Book

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