| Title | Digital imaging in pathology: whole-slide imaging and beyond. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Ghaznavi, F, Evans A, Madabhushi A, Feldman MD |
| Journal | Annual review of pathology |
| Volume | 8 |
| Pagination | 331-59 |
| Date Published | 2013 Jan 24 |
| ISSN | 1553-4014 |
| Keywords | Diagnostic Imaging, Humans, Reproducibility of Results |
| Abstract | Digital imaging in pathology has undergone an exponential period of growth and expansion catalyzed by changes in imaging hardware and gains in computational processing. Today, digitization of entire glass slides at near the optical resolution limits of light can occur in 60 s. Whole slides can be imaged in fluorescence or by use of multispectral imaging systems. Computational algorithms have been developed for cytometric analysis of cells and proteins in subcellular locations by use of multiplexed antibody staining protocols. Digital imaging is unlocking the potential to integrate primary image features into high-dimensional genomic assays by moving microscopic analysis into the digital age. This review highlights the emerging field of digital pathology and explores the methods and analytic approaches being developed for the application and use of these methods in clinical care and research settings. |
| DOI | 10.1146/annurev-pathol-011811-120902 |
| PDF Link | http://engineering.case.edu/centers/ccipd/sites/ccipd.case.edu/files/pub... |
| Alternate Journal | Annu Rev Pathol |
*IEEE COPYRIGHT NOTICE: 1997 IEEE. * Personal use of this material is permitted. However, permission to reprint/ republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
*COPYRIGHT NOTICE:* These materials are presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.
