Pallavi Tiwari, PhD, Anant Madabhushi, PhD, and their collaborator Jhimli Mitra have been awarded the patent, “Quantifying mass effect deformation with structural radiomics in brain tumor patients”. The collaborators fondly remember the late Gavin Hanson, CWRU MD/PhD student, who was also a collaborator on this patent.
USSN: 10,614,567; April 7, 2020
Inventors: Anant Madabhushi, Pallavi Tiwari, Gavin Hanson, Jhimli Mitra
Abstract: Methods and apparatus quantify mass effect deformation in diagnostic images of patients demonstrating glioblastoma multiforme (GBM). One example apparatus includes an image acquisition circuit that acquires an image of a region of tissue demonstrating GBM pathology, a delineation circuit that segments a tumor region from the image, a pre-processing circuit that generates a pre-processed image by pre-processing the segmented image, a registration circuit that registers the pre-processed image with a template image of a healthy brain, a deformation quantification circuit that computes a set of differences between a position of a brain sub-structure represented in the registered image relative to the position of the brain sub-structure represented in the template image. Embodiments may include a classification circuit that classifies the region of tissue as a long or short-term survivor based, at least in part, on the set of differences.
