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Metabolomics & Systems Biology


Metabolic Systems

Mathematical modeling and computer simulation are used to analyze changes in cellular metabolism of tissues, organs, and the whole body. Non-invasive or minimally invasive measurements are obtained with human exercise studies under normal and diseased conditions. Cellular metabolic changes are quantitatively related to physiological changes. Projects include cellular metabolic mechanisms of myocardial ischemia, cellular metabolism and energetics in skeletal muscle, adipose tissue metabolism with insulin resistance, and whole-body energy balance.
 


Cardiac and Vascular Systems

Cellular and molecular imaging technologies and mathematical modeling are combined with molecular, cellular, and tissue measurements to analyze mechanisms of heart disease. Therapeutic strategies are developed related to biomechanical, vascular, and electrophysiological functions. Cardiovascular physiology and metabolic regulation are studied using ECG signals, magnetic resonance imaging, optical mapping, and spectroscopy. Projects include cellular mechanisms of sudden cardiac death, cell and gene therapy for arrhythmias, ion channel structure and function, and myocardial ischemia.
 


Biomedical Sensors

Biomedical sensing integrates biologically derived sensing components with a transducer for in vitro and in vivo measurements of chemical and biological substances. Research includes the development and use of electrochemical, optical mini- and micro-sensors, micro-fabricated devices such as BioMEMS chips, quantitative analysis of cellular transport and communication, cost-effective in vitro diagnostics, and continuous in vivo diagnostics.

 

 

Faculty

Miklos Gratzl, Ph.D.

Biomedical sensing and diagnostics in vitro and in vivo; electrochemical and optical techniques; BioMEMS for cellular transport; cancer multi-drug resistance at the single cell level; and sliver sensor for multi-analyte patient monitoring
 

Gerald Saidel, Ph.D.

Mass and heat transport and metabolism in cells, tissues, and organ systems; mathematical modeling and simulation of dynamic and spatially distributed systems; optimal nonlinear parameter estimation and design of experiments

 

Xin Yu, Sc.D.

Magnetic resonance imaging and spectroscopy; applications of MRI and MRS to cardiovascular research

 

 

Research Faculty

Niloy Bhadra, M.D., Ph.D.

Experimental and computational studies of high frequency waveforms for reversible conduction block of peripheral nerves; design, testing and implementation of neuroprosthetic systems for the upper limb

 

 

Associated Faculty

Henri Brunnengrabber, Professor of Nutrition

Charles Hoppel, Professor of Pharmacology

Satish Kalhan, Professor of PathobiologyCCF

John Kirwan, Professor of Pathology, CCF

Joseph LaManna, Professor of Physiology and Biophysics

Raymond Muzic, Associate Professor of radiology

Michelle Puchowicz, Associate Professor of Nutrition