Online Master's in Biomedical Engineering @ Case.edu
From Black-eyed-Peas to Nanotechnology
Mining Data for Medical Breakthroughs
Cleveland - A Powerhouse for Partnerships
Man with quadriplegia employs injury bridging technologies to move again—just by thinking
Q&A with Zheng-Rong Lu
Driving Ingenuity at the Interactive Commons

Capadona Funding

Active PI / Co-PI Funding

N/A (Capadona and Luciano)

Wallace H. Coulter Foundation Administered Through Case Western Reserve University

9/3/2013 – 7/31/2016

$75,000 ADC

CWRU Effort

 

Role: Co-PI

 

Preventing infection of ventricular shunts

The goal of this project is to prevent ventricular shunt infections.  We will focus on developing affinity based drug delivery methods to release antibiotics from the surface of the shunts.  Initial targets will focus on bacterial strains not currently treatable.

 

 

R01 (Capadona)

National Institutes of Health

NINDS

Grant # RNS082404A

9/1/2013 - 8/30/2017

$2,302,414 DC

CWRU Effort

 

Role: PI

 

 

Cluster of Differentiation 14 facilitates neural device integration and performance

The central hypothesis is that CD14 inhibition will attenuate microelectrode encapsulation and neuronal die-back, resulting in reduced tissue impedance and more stable and higher numbers of isolated unit recordings from implanted microelectrodes. The current proposal will build from the PI's preliminary results indicated the role of CD14 in neural device-associated inflammation. A transgenic rodent intracortical microelectrode model will be used to complete the characterization of the role of CD14 in neuroinflammation.  Additionally, novel CD14 antagonist will be further investigated as a therapeutic means to inhibit device-associated neuroinflammation and improve the longevity of device performance. The successful completion of this project will provide clear support for our central hypothesis, and will help facilitate the translation of this promising technology to treat patients.

 

Award (Capadona)

Department of Veteran’s Affairs

RR&D

 

10/1/2012 - 9/30/2017

$125,000 DC

VA Effort

 

Role = PI

Presidential Early Career Award for Scientists and Engineers

This award is giving from the President of the United States following nomination from the Department of Veterans Affairs, for early career achievements.  The funding is not tied to a specific research project.

Merit Review (Capadona)

Department of Veteran’s Affairs

RR&D

Grant # B1495-R

7/1/2014 - 6/30/2018

$1,094,716 DC

VA Effort

 

Role: PI

 

 

Resveratrol Prevents Microelectrode Mediated Neurodegeneration

This project builds on our recent findings that acute attenuation of reactive oxygen species (ROS) accumulation at the intracortical microelectrode – tissue interface prevents neurodegeneration and device-assocaited inflammation.  In the proposed study, we will investigate the effects of sustained delviery of Resveratrol to improve the qualitiy and longevity of chronic neural recordings in seveal animal models, utilizing multiple elelctrode types.  This study will establish an approach to improve neural recordings. 

CDMRP (Pancrazio / Capadona)

Department of Defense

Grant # 11766813

10/1/2015-9/30/18

$1,500,000 DC

($678,532 – Capadona Budget)

VA Effort

 

Role: Co-PI

 

The Effect of the Elimination of Micromotion and Tissue Strain on Intracortical Device Performance

In this study, we will systematically examine the effects of softening microelectrodes, which reduce the micromotion and tissue strain effects, on the neuroinflammatory response and recording capability of chronically implanted intracortical microelectrodes arrays. When successful, this study will for the first time answer a 30+ year old hypothesis of the field, and provide a framework leading to the development of new generations of implantable cortical interfaces capable of long-term reliability.

 

 

Active / Award Co-I Funding

Merit Review (Potkay)

Department of Veteran’s Affairs

RR&D

Grant # 2I01RX000390-04A2

5/1/2015 – 4/30/2018                  $824,944 DC

 

VA Effort

 

Role = Co-Investigator

Towards portable microchannel artificial lungs for veteran rehabilitation

The long-term goal of this technology development project is improve the rehabilitation of veterans suffering from acute and chronic lung diseases through the development of the first truly portable, biocompatible, artificial lung capable of short and long term respiratory support. The objective of the current Merit Review proposal, which is a step toward attainment of the long-term goal, is to develop the construction techniques required to scale the device up in size, to enhance biocompatibility, and to perform initial lifetime studies in animals.

 

 

Research Center of Excellence

Department of Veteran’s Affairs

RR&D

Grant # A1871-C

01/01/2015 - 12/31/19

$ 5,000,000 DC

VA Effort

 

Role = Co-Investigator

Advanced Platform Technology Center of Excellence

Together with basic science and engineering faculty at CWRU, and other notable institutions like the Cleveland Clinic, we leverage the latest advances in microfabrication, microelectronics and microsystems, material science, neuroscience and neural engineering, and additive manufacturing, and apply them to the highest medical priorities of the Veterans Health Administration.  Our efforts are concentrated in four primary areas:  Enabling Technologies, Neural Interfacing, Health Monitoring/Maintenance and Prosthetics/Orthotics.  “Enabling Technologies” refers to the new materials, microfabrication processes, and encapsulation, encoding or sensing methods that make many otherwise intractable clinical applications not only possible, but practical.